Results 71 to 80 of about 179,788 (299)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Redox-active ferrocene-modified Cowpea mosaic virus nanoparticles [PDF]

, 2010
A naturally occurring nanoparticle, the plant virus Cowpea mosaic virus, can be decorated with ferrocene derivatives, of various linker lengths with amine and carboxylategroups, on the external surface using a range of conjugation strategies.
Alaa A. A. Aljabali, Astruc, Beasley, Chatterji, Chidsey, Constable, David J. Evans, Evans, Evans, Frederix, George P. Lomonossoff, Green, J. Elaine Barclay, Julea N. Butt, Lin, Lomonossoff, Lopez, Molina, Newkome, Padeste, Steinmetz, Steinmetz, Steinmetz, Togni, Wang, Wang, Wellink, Yang, Yang   +28 more
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Enhancing isomer specificity in mass spectrometry by combining silver ion adduction and ion mobility

Talanta Open
Background: Identification and characterization of steroids from complex mixtures with isomeric precision is key to studying endocrine-related metabolism and disorders.
Varun V. Sharma, Danjo De Chavez, Susan E. Slade, Ingela Lanekoff   +3 more
doaj   +1 more source

Frequency dependent deformation reversibility during cyclic loading

Materials Research Letters, 2018
High-frequency testing (HFT) is useful for accelerated fatigue testing of conventional materials that typically serve under low-frequency loading conditions, as well as for the assessment of the robustness of microelectromechanical systems which ...
Shuai Shao, Michael M. Khonsari, Jian Wang, Nima Shamsaei, Nan Li   +4 more
doaj   +1 more source

Impact of Training in Sports Games and Cyclic Sports Events on Cardiovascular System, Motor and Sensomotor Abilities of 11—14 Year-Old Boys

Baltic Journal of Sport and Health Sciences, 2018
Individual development depends not only on inherent qualities but also on the effective influence of the environment. The aim of this study was to compare the effect of variable intensity as partially regulated physical loads which are appropriate for ...
Arūnas Emeljanovas, Jonas Poderys, Eurelija Venskaitytė   +2 more
doaj   +1 more source

Coupled electronic and morphologic changes in graphene oxide upon electrochemical reduction [PDF]

, 2015
Peer ...
Angel Cuesta, Ernesto C. Pereira, Fernando C. Moraes, Luiz F. Gorup, Renato G. Freitas, Rodrigo Pereira   +5 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Generalized shear strain-based model for development of excess pore water pressure in saturated sand under anisotropic consolidation

Yantu gongcheng xuebao
The development pattern of the excess pore water pressure in saturated sand under anisotropic consolidation conditions is crucial for understanding the liquefaction behavior of sand.
ZHAO Futang, WU Qixin, ZHENG Junjie, ZHENG Yewei
doaj   +1 more source