Results 71 to 80 of about 635,495 (333)

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Steel-Based Electrocatalysts for Efficient and Durable Oxygen Evolution in Acidic Media

, 2018
High overpotentials, particularly an issue of common anode materials, hamper the process of water electrolysis for clean energy generation. Thanks to immense research efforts up to date oxygen evolution electrocatalysts based on earth-abundant elements ...
Daum, Diemo, Han, Weijia, Hou, Peilong, Krupp, Ulrich, Küpper, Karsten, Liu, Xiaogang, Müller-Buschbaum, Klaus, Schmidt, Mercedes, Schulz-Kölbel, Christine, Schäfer, Helmut, Stangl, Johannes, Steinhart, Martin, Wollschläger, Joachim   +12 more
core   +1 more source

Cyclic electric field stress on bipolar resistive switching devices [PDF]

, 2013
We have studied the effects of accumulating cyclic electrical pulses of increasing amplitude on the non-volatile resistance state of interfaces made by sputtering a metal (Au, Pt) on top of the surface of a cuprate superconductor YBa$_2$Cu$_3$O$_{7 ...
Acha, Carlos, Schulman, Alejandro
core   +4 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Synthesis and Crystallographic Characterization of Heteroleptic Ir(III) Complexes Containing the N-oxide Functional Group and Crystallographic Characterization of Ir(III) N-oxide Precursors

Crystals
The N-oxide functional group has been exploited for synthetic strategies and drug design, and it has been utilized in imaging agents. Herein, we present rare examples of neutral heteroleptic cyclometallated Ir(III) compounds that contain an uncoordinated
Emily E. Stumbo, Emarald K. Hodge, Matthew Williams, Diana A. Thornton, Colin D. McMillen, Jared A. Pienkos   +5 more
doaj   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Characterization of Shewanella oneidensis MtrC: a cell-surface decaheme cytochrome involved in respiratory electron transport to extracellular electron acceptors [PDF]

, 2007
MtrC is a decaheme c-type cytochrome associated with the outer cell membrane of Fe(III)-respiring species of the Shewanella genus. It is proposed to play a role in anaerobic respiration by mediating electron transfer to extracellular mineral oxides that ...
AI Tsapin, AJ Bard, AS Beliaev, AS Beliaev, BH Kim, Brian N. Jepson, C Myers, C Myers, C Schwalb, CR Myers, CR Myers, CR Myers, CR Myers, D Leys, David J. Richardson, DJ Richardson, E Berry, EHJ Gordon, FA Walker, GR Moore, HJ Kim, I Gautier-Luneau, J Hirst, JF Heidelberg, Jim Fredrickson, JK Fredrickson, JM Myers, JM Myers, JM Philo, John Zachara, Julea N. Butt, K Venkateswaren, KE Pitts, KH Nealson, KH Nealson, Kurnikov, L Shi, L Shi, Liang Shi, LJ Anderson, MG Almeida, MP Hendrich, MP Hendrich, PL Dutton, PS Dobbin, R Aasa, Robert S. Hartshorne, Sarah J. Field, SJ Field, T Horan, TA Clarke, Tom A. Clarke, VA Bamford   +52 more
core   +1 more source

Synthesen und Reaktionen von 5H-Dibenz[c.e]azepin-N-oxiden / Syntheses and Reactions of 5H-Dibenz[c.e]azepine-N-oxides

, 1974
5H-Dibenz[c,e]azepine-N-oxides were prepared by oxidation of the corresponding N-hydroxy-6,7-dihydro-5H-dibenz[c.e]azepines. Reactions of the isolated cyclic nitrones towards nucleophiles, dienophiles and dipolarophiles have been examined.
R. Kreher, H. Pawelczyk
semanticscholar   +1 more source

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source