Results 271 to 280 of about 2,011,052 (344)

An mRNA-display derived cyclic peptide scaffold reveals the substrate binding interactions of an N-terminal cysteine oxidase. [PDF]

Nat Commun
Jiramongkol Y, Patel K, Johansen-Leete J, Maxwell JWC, Chang Y, Du JJ, Passioura T, Cook KM, Payne RJ, White MD.   +9 more
europepmc   +1 more source

NIBV Induces Incomplete Autophagy via AMPK‐TFEB, Causing Kidney Injury in Chicks

Advanced Science, EarlyView.
This study reveals that NIBV can inhibit the nuclear translocation of TFEB by suppressing the expression of AMPK, leading to the blockade of autophagolysosomal functions, in turn increasing NIBV replication and triggering severe kidney injury in chicks.
Cheng Huang, Yizhou Zeng, Yunfeng Chen, Zhengqing Li, Salma Mbarouk Omar, Shengwei Zhong, Ping Liu, Zhanhong Zheng, Gaofeng Cai, Xiaona Gao, Xiaoquan Guo   +10 more
wiley   +1 more source

Flexibility-tuning of dual-display DNA-encoded chemical libraries facilitates cyclic peptide ligand discovery. [PDF]

Nat Commun
Petrov D, Plais L, Schira K, Cai J, Keller M, Lessing A, Bassi G, Cazzamalli S, Neri D, Gloger A, Scheuermann J.   +10 more
europepmc   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Identification of Covalent Cyclic Peptide Inhibitors Targeting Protein-Protein Interactions Using Phage Display. [PDF]

J Am Chem Soc
Wang S, Faucher FF, Bertolini M, Kim H, Yu B, Cao L, Roeltgen K, Lovell S, Shanker V, Boyd SD, Wang L, Bartenschlager R, Bogyo M.   +12 more
europepmc   +1 more source

Cyclic Peptide Natural Product Inspired Inhibitors of the Free-Living Amoeba <i>Balamuthia mandrillaris</i>. [PDF]

J Nat Prod
Lu C, Nelson S, Coy G, Neumann C, Parkinson EI, Rice CA.   +5 more
europepmc   +1 more source

Author Correction: Characterisation of a cyclic peptide that binds to the RAS binding domain of phosphoinositide 3-kinase p110α. [PDF]

Sci Rep
Ismail M, Martin SR, George R, Houghton F, Kelly G, Chaleil RAG, Anastasiou P, Wang X, O'Reilly N, Federico S, Joshi D, Nagaraj H, Cooley R, Hui NS, Molina-Arcas M, Hancock DC, Tavassoli A, Downward J.   +17 more
europepmc   +1 more source

A cyclic peptide toolkit reveals mechanistic principles of peptidylarginine deiminase IV regulation. [PDF]

Nat Commun
Bertran MT, Walmsley R, Cummings T, Aramburu IV, Benton DJ, Mora Molina R, Assalaarachchi J, Chasampalioti M, Swanton T, Joshi D, Federico S, Okkenhaug H, Yu L, Oxley D, Walker S, Papayannopoulos V, Suga H, Christophorou MA, Walport LJ.   +18 more
europepmc   +1 more source

Development of selective nanomolar cyclic peptide ligands as GBA1 enzyme stabilisers. [PDF]

RSC Chem Biol
Katzy RE, van Neer RHP, Ferraz MJ, Nicolai K, Passioura T, Suga H, Jongkees SAK, Artola M.   +7 more
europepmc   +1 more source

Anti-Inflammatory Effects of Clarstatin, a Shared-Epitope-Antagonistic Cyclic Peptide, on Experimental Autoimmune Uveitis in Mice. [PDF]

Invest Ophthalmol Vis Sci
Merzbach S, Schumacher-Klinger A, Klazas M, Hoffman A, Lazarovici P, Gilon C, Nussbaum G, Amer R.   +7 more
europepmc   +1 more source