Results 281 to 290 of about 2,011,052 (344)

Cyclic peptide structure prediction and design using AlphaFold2 [PDF]

Nat Commun
Small cyclic peptides have gained significant traction as a therapeutic modality; however, the development of deep learning methods for accurately designing such peptides has been slow, mostly due to the lack of sufficiently large training sets. Here, we
Stephen A. Rettie, Katelyn V. Campbell, A. Bera, A. Kang, Simon Kozlov, Yensi Flores Bueso, Joshmyn De La Cruz, Maggie Ahlrichs, Suna Cheng, Stacey R. Gerben, M. Lamb, Analisa Murray, V. Adebomi, Guangfeng Zhou, F. Dimaio, Sergey Ovchinnikov, Gaurav Bhardwaj   +16 more
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Synthesis of Cyclic Peptides and Cyclic Proteins via Ligation of Peptide Hydrazides

ChemBioChem, 2012
Intramolecular ligation of peptide hydrazides is reported to occur readily, causing the lactamization of fully unprotected peptides in an epimerization-free manner. This method relies on the routine procedures of Fmoc solid-phase peptide synthesis. It can be used to prepare cyclic peptides and cyclic proteins under simpler, mild conditions at lower ...
Ji-Shen Zheng, Ye Guo, Lei Liu
exaly   +3 more sources

Assessment of solvent effects on the inclusion behavior of pyrazinamide drug into cyclic peptide based nanotubes as novel drug delivery vehicles

Journal of Molecular Liquids, 2018
In the present work, the encapsulation process of Pyrazinamide drug into the cyclic peptide nanotubes with the different numbers of cyclic peptides as novel drug carriers is investigated using density functional theory calculations in the aqueous medium.
Mahnaz Shahabi, Heidar Raissi
exaly   +2 more sources

Discovery of a head-to-tail cyclic peptide as the Keap1-Nrf2 protein-protein interaction inhibitor with high cell potency

European Journal of Medicinal Chemistry, 2018
Meng-Chen Lu, Qidong You, Zheng-Yu Jiang   +2 more
exaly   +2 more sources

Identification of Covalent Cyclic Peptide Inhibitors in mRNA Display

Journal of the American Chemical Society, 2023
Peptides have historically been underutilized for covalent inhibitor discovery despite their unique abilities to interact with protein surfaces and interfaces.
Sabrina E Iskandar, Lilly F. Chiou, T. Leisner, Devan J. Shell, Jacqueline L. Norris-Drouin, C. Vaziri, K. Pearce, A. Bowers   +7 more
semanticscholar   +1 more source

Cyclic Peptide Screening Methods for Preclinical Drug Discovery.

Journal of Medicinal Chemistry, 2022
Cyclic peptides are among the most diverse architectures for current drug discovery efforts. Their size, stability, and ease of synthesis provide attractive scaffolds to engage and modulate some of the most challenging targets, including protein-protein ...
Xinting Li, Timothy W. Craven, Paul M. Levine   +2 more
semanticscholar   +1 more source

Cyclic Peptides

International Journal of Peptide and Protein Research, 1986
In order to investigate the role of the L‐2‐hydroxy‐3‐methylbutanoic acid residue at position 2 of AM‐toxin I (cyclic tetradepsipeptide) on necrotic activity for apple leaves, two analogs, [L‐lactic acid2] AM‐toxin I and [L‐2‐hydroxy‐4‐methylpentanoic acid2] AM‐toxin I, were synthesized by the conventional method for peptide synthesis.
HISAKAZU MIHARA, KOICHI IKESUE, SANNAMU LEE, HARUHIKO AOYAGI, TETSUO KATO, TAMIO UENO, NOBUO IZUMIYA   +6 more
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Orally Absorbed Cyclic Peptides [PDF]

Chemical Reviews, 2017
Peptides and proteins are not orally bioavailable in mammals, although a few peptides are intestinally absorbed in small amounts. Polypeptides are generally too large and polar to passively diffuse through lipid membranes, while most known active transport mechanisms facilitate cell uptake of only very small peptides. Systematic evaluations of peptides
Daniel S. Nielsen, Nicholas E. Shepherd, Weijun Xu, Andrew J. Lucke, Martin J. Stoermer, David P. Fairlie   +5 more
openaire   +4 more sources

Rotaxanes of Cyclic Peptides

Journal of the American Chemical Society, 2006
The synthesis of rotaxanes derived from the synthetic peptide macrocycles cyclo(l-ProGly)4 and cyclo(l-ProGly)5 and diammonium threads is described. [2]Rotaxanes are formed in good yields (56-63%), despite the disruption of internal amide-amide hydrogen bonding in the macrocycles.
Vincent, Aucagne, David A, Leigh, Julia S, Lock, Andrew R, Thomson   +3 more
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Cyclic peptides.

International Journal of Peptide and Protein Research, 1985
cyclo(‐l‐Pro‐l‐Val‐l‐Pro‐l‐Val‐) (1L) and cyclo(‐l‐Pro‐d‐Val‐l‐Pro‐d‐Val‐) (1D) were synthesized by the conventional method for peptide synthesis. Conformations of 1L and 1D in solution were studied. Compound 1L has a cis‐trans‐cis‐trans backbone conformation with C2 symmetry in CDCl3.
TOSHIHISA UEDA, ISAO SADA, TETSUO KATO, NOBUO IZUMIYA   +3 more
openaire   +1 more source