Results 301 to 310 of about 2,011,052 (344)

Cyclic peptides as drugs for intracellular targets: the next frontier in peptide therapeutic development.

Chemistry, 2020
Developing macrocyclic peptides that can reach intracellular targets is a significant challenge. This review discusses the most recent strategies used to develop cell permeable cyclic peptides that maintain binding to their biological target inside the ...
L. Buckton, Marwa N. Rahimi, S. McAlpine
semanticscholar   +1 more source

Synthesis of cyclic tryptathionine peptides

International Journal of Peptide and Protein Research, 1987
The helicity of the tryptathionine moiety of the phallotoxins has been recognized by comparison with cyclic tryptathionine tripeptides. In order to investigate the influence of the configuration of the component amino acids on the conformation of the cyclic peptides, six analogue thioether tripeptides containing L‐ and D‐alanine and L‐ and D‐cysteine ...
Zanotti, G., Beijer, B., Wieland, T.
openaire   +3 more sources

Synthesis of Cyclic Endiamino Peptides

Journal of the American Chemical Society, 2005
Several building blocks for endiamino peptides, as well as several cyclic endiamino peptides themselves, and pyrazin-6-one, which embodies the endiamino group, were prepared. The variety of synthesized compounds shows the potential of this synthesis in the preparation of many different groups of compounds.
Doron, Pappo, Maida, Vartanian, Steffen, Lang, Yoel, Kashman   +3 more
openaire   +2 more sources

Cyclic Peptide-Based and Cyclic Peptide–Polymer-Based Nanotubes

2021
Rationally designed cyclic peptides (CPs), if composed of even numbers (e.g., 4, 6, 8, 10, or 12) of alternating d- and l-amino acid residues, could stack one another to appear as nanotube structures through self-assembly. The critical interaction to stabilize the nanotubes is an adjacent β-sheet-like intermolecular hydrogen bonding between ring-shaped
openaire   +1 more source

A NOVEL CYCLIC OCTAPEPTIDE AS AN ANALOGUE OF CYCLIC PEPTIDE IN TRIOSTIN A

Preparative Biochemistry and Biotechnology, 2002
This paper reported an ongoing study of cyclic peptides as carriers of potential anti-tumor agents. In an effort to carry out anti-cancer drug design, we synthesized another novel cyclic peptide as the analogue of the cyclic peptide in Triostin A. The linear peptide chains were synthesized by coupling protected amino acid residues according to Pfp/DCC ...
Pin, Yang, Yufei, Song
openaire   +2 more sources

Synthesis of cyclic α-MSH peptides

Letters in Peptide Science, 1998
Cyclic lactam analogs of α-melanocyte stimulating hormone (α-MSH) have been shown to be potent agonists in the frog skin bioassay [Al-Obeidi, F. et al., J. Med. Chem., 32 (1989) 2555], demonstrating melanocortin-1 (MC1) receptor activity. We synthesized cyclic α-MSH(1-13) and α-MSH(4-10) lactam analogs.
Gispen, W.H., Schaaper, W.M.M.., Adan, R.A.H., Posthuma, T.A., Oosterom, J., Meloen, R.H.   +5 more
openaire   +3 more sources

ChemInform Abstract: Head‐to‐Tail Cyclic Peptides and Cyclic Peptide Libraries

ChemInform, 2000
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Arno F. Spatola, Peteris Romanovskis
openaire   +1 more source

Cyclic Peptides for Lanthanide Binding

The Journal of Physical Chemistry B
Lanthanide ions are difficult to separate from one another due to their similar chemical properties. The discovery of lanthanide-binding peptides and proteins in nature has led to an increased interest in the possibility of utilizing the strong binding of peptides to lanthanide ions for their separations; as such, there has been an effort to identify ...
Sina Chiniforoush, Oksana Fizer, Ana de Bettencourt-Dias, David C. Cantu   +3 more
openaire   +2 more sources

Cyclic β-sheet peptides

Our laboratory has developed a class of cyclic β-sheet peptides to study the folding and supramolecular assembly of β-sheets. The peptides consist of a peptide sequence of interest incorporated into a macrocycle with the β-strand mimic Hao and δ-linked ornithine units.
Jovanna I, Carrera Plancarte, James S, Nowick   +1 more
openaire   +2 more sources

Cyclic, Modified and Conjugated Peptides

ChemInform, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
openaire   +1 more source