Results 291 to 300 of about 2,011,052 (344)
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Engineering Cyclic Peptide Toxins
2012Peptide-based toxins have attracted much attention in recent years for their exciting potential applications in drug design and development. This interest has arisen because toxins are highly potent and selectively target a range of physiologically important receptors.
Clark, Richard J., Craik, David J.
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International Journal of Peptide and Protein Research, 1984
In order to explore the route for cyclization of linear oligopeptide containing a ΔAla (α, β‐dehydroalanine) residue, AM‐toxin II was synthesized. As a preliminary experiment, synthesis of [L‐Phe3] AM‐toxin II, containing L‐Phe in place of L‐App (L‐2‐amino‐5‐phenylpentanoic acid), was attempted.
TOSHIRO KOZONO +4 more
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In order to explore the route for cyclization of linear oligopeptide containing a ΔAla (α, β‐dehydroalanine) residue, AM‐toxin II was synthesized. As a preliminary experiment, synthesis of [L‐Phe3] AM‐toxin II, containing L‐Phe in place of L‐App (L‐2‐amino‐5‐phenylpentanoic acid), was attempted.
TOSHIRO KOZONO +4 more
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The coming of age of cyclic peptide drugs: an update on discovery technologies
Expert Opinion on Drug DiscoveryIntroduction Cyclic peptides are an established class of pharmaceuticals, with the ability to bind to a broader range of protein targets than traditional small molecules while also being capable of oral availability and cell penetration.
Sophia W You +2 more
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International Journal of Peptide and Protein Research, 1981
In order to establish possible routes for the synthesis of AM‐toxins, cyclotetradepsipeptides containing Dha, Pyr‐L‐Ala‐L‐Hmb‐L‐Tyr‐NH2 were prepared and treated with TFA or anhydrous HF. The product was identified to be cyclo (‐α‐Hyala‐L‐Ala‐L‐Hmb‐L‐Tyr‐), resulting from intramolecular condensation of the α‐keto and amide group with the formation of ...
Kosaku Noda +4 more
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In order to establish possible routes for the synthesis of AM‐toxins, cyclotetradepsipeptides containing Dha, Pyr‐L‐Ala‐L‐Hmb‐L‐Tyr‐NH2 were prepared and treated with TFA or anhydrous HF. The product was identified to be cyclo (‐α‐Hyala‐L‐Ala‐L‐Hmb‐L‐Tyr‐), resulting from intramolecular condensation of the α‐keto and amide group with the formation of ...
Kosaku Noda +4 more
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International Journal of Peptide and Protein Research, 1980
Å number of cyclo (Δaminoacyl‐L‐aminoacyl) (Δaminoacyl =ΔAba, ΔVal, ΔLeu, ΔApp, ΔPhe and ΔTrp; L‐aminoacyl=L‐Ala, L‐Val, L‐Leu and L‐Lys (e‐Ac)) were synthesized by the condensation of cyclo (N‐acetyl‐Gly‐N‐acetyl‐L‐aminoacyl) with corresponding aldehyde or acetone and subsequent treatment with hydrazine. Each cyclo (Δaminoacyl‐L‐aminoacyl) except ones
TATSUHIKO KANMERA +3 more
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Å number of cyclo (Δaminoacyl‐L‐aminoacyl) (Δaminoacyl =ΔAba, ΔVal, ΔLeu, ΔApp, ΔPhe and ΔTrp; L‐aminoacyl=L‐Ala, L‐Val, L‐Leu and L‐Lys (e‐Ac)) were synthesized by the condensation of cyclo (N‐acetyl‐Gly‐N‐acetyl‐L‐aminoacyl) with corresponding aldehyde or acetone and subsequent treatment with hydrazine. Each cyclo (Δaminoacyl‐L‐aminoacyl) except ones
TATSUHIKO KANMERA +3 more
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International Journal of Peptide and Protein Research, 1977
Synthesis of a cyclohexadepsipeptide corresponding to the sequence of protodestruxin from linear hexapeptides was attempted through five different routes in a conventional method, and three routes afforded the same cyclopeptide. Biological and physicochemical properties of the synthetic peptide were identical to those of natural protodestruxin ...
S, Lee, N, Izumiya
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Synthesis of a cyclohexadepsipeptide corresponding to the sequence of protodestruxin from linear hexapeptides was attempted through five different routes in a conventional method, and three routes afforded the same cyclopeptide. Biological and physicochemical properties of the synthetic peptide were identical to those of natural protodestruxin ...
S, Lee, N, Izumiya
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Studies on cyclic peptides. II. Synthesis of cyclic peptides containing sarcosine
Biopolymers, 1975AbstractCyclic peptides containing sarcosine, cyclo‐(Pro‐Sar‐Gly)2, cyclo‐(Sar‐Sar‐Gly)2, cyclo‐(Sar4), and cyclo‐(Sar6) have been synthesized by the cyclization of the p‐nitrophenyl ester of linear peptides. The tert‐butoxycarbonyl group was used as the Nα‐protecting group, which was removed by acid.
T, Sugihara, Y, Imanishi, T, Higashimura
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Cyclic, modified and conjegated peptides
1993The subject matter for this Chapter has again been allocated sub-headings that reflect main subject areas under which a reasonable number of publications have been cited. In the absence of a detailed keyword index, the sub-headings also provide continuity from previous volumes, so that searching the...
J. S. Davies, John S. Davies
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Fragmentation of biotinylated cyclic peptides
Rapid Communications in Mass Spectrometry, 2004Abstract Electrospray ionization coupled with tandem mass spectrometry (MS/MS) was used to determine the preferred binding site(s) of biotin NHS ester with a series of cyclic peptides with antibiotic properties.
Michael E, Lassman +2 more
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