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Cyclic Peptides in Pipeline: What Future for These Great Molecules? [PDF]
Pharmaceuticals (Basel), 2023 Cyclic peptides are molecules that are already used as drugs in therapies approved for various pharmacological activities, for example, as antibiotics, antifungals, anticancer, and immunosuppressants.
Costa L, Sousa E, Fernandes C.
europepmc +4 more sources
Plant derived cyclic peptides [PDF]
Biochemical Society Transactions, 2021 Cyclic peptides are widespread throughout the plant kingdom, and display diverse sequences, structures and bioactivities. The potential applications attributed to these peptides and their unusual biosynthesis has captivated the attention of researchers ...
N. Daly, David T. Wilson
semanticscholar +4 more sources
De novo development of small cyclic peptides that are orally bioavailable. [PDF]
Nat Chem Biol, 2023 Cyclic peptides can bind challenging disease targets with high affinity and specificity, offering enormous opportunities for addressing unmet medical needs. However, as with biological drugs, most cyclic peptides cannot be applied orally because they are
Merz ML +9 more
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Cyclic Peptides for Drug Development.
Angewandte Chemie International Edition, 2023 Cyclic peptides are fascinating molecules abundantly found in nature and exploited as molecular format for drug development as well as other applications, ranging from research tools to food additives.
Xinjian Ji +2 more
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CyclicPepedia: a knowledge base of natural and synthetic cyclic peptides. [PDF]
Brief BioinformCyclic peptides offer a range of notable advantages, including potent antibacterial properties, high binding affinity and specificity to target molecules, and minimal toxicity, making them highly promising candidates for drug development.
Liu L +7 more
europepmc +2 more sources
Current Medicinal Chemistry, 2016 For decades the opioid receptors have been an attractive therapeutic target for the treatment of pain. Since the first discovery of enkephalin, approximately a dozen endogenous opioid peptides have been known to produce opioid activity and analgesia, but their therapeutics have been limited mainly due to low blood brain barrier penetration and poor ...
Michael, Remesic +2 more
openaire +2 more sources
CycPeptMPDB: A Comprehensive Database of Membrane Permeability of Cyclic Peptides
Journal of Chemical Information and Modeling, 2023 Recently, cyclic peptides have been considered breakthrough drugs because they can interact with “undruggable” targets such as intracellular protein–protein interactions.
Jianan Li +5 more
semanticscholar +1 more source
Nature Communications, 2023 Naturally occurring peptides with high membrane permeability often have ester bonds on their backbones. However, the impact of amide-to-ester substitutions on the membrane permeability of peptides has not been directly evaluated.
Yuki Hosono +16 more
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Journal of Medicinal Chemistry, 2023 Cyclic peptides extend the druggable target space due to their size, flexibility, and hydrogen-bonding capacity. However, these properties impact also their passive membrane permeability.
Stephanie M. Linker +8 more
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Design of Cyclic Peptides Targeting Protein–Protein Interactions Using AlphaFold
bioRxiv, 2023 More than 930,000 protein-protein interactions (PPIs) have been identified in recent years, but their physicochemical properties differ from conventional drug targets, complicating the use of conventional small molecules as modalities.
Takatsugu Kosugi, M. Ohue
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