Cyclic Peptides in Pipeline: What Future for These Great Molecules? [PDF]
Pharmaceuticals, 2023 Cyclic peptides are molecules that are already used as drugs in therapies approved for various pharmacological activities, for example, as antibiotics, antifungals, anticancer, and immunosuppressants.
Lia Costa +2 more
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Bioinformatics-Assisted Discovery of Antioxidant Cyclic Peptides from Corn Gluten Meal [PDF]
FoodsUsing a multidisciplinary approach, this paper was designed to prepare, identify, and characterize novel maize antioxidant cyclic peptides from protein hydrolysate of corn gluten meal (CGM).
Hongcheng Liu +8 more
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C2PO: an ML-powered optimizer of the membrane permeability of cyclic peptides through chemical modification [PDF]
Journal of CheminformaticsPeptide drug development is currently receiving due attention as a modality between small and large molecules. Therapeutic peptides represent an opportunity to achieve high potency, selectivity, and reach intracellular targets.
Roy Aerts +6 more
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Rational design of glycosaminoglycan binding cyclic peptides using cPEPmatch [PDF]
Computational and Structural Biotechnology JournalCyclic peptides present a robust platform for drug design, offering high specificity and stability due to their conformationally constrained structures.
Brianda L. Santini +6 more
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Chemical Properties, Preparation, and Pharmaceutical Effects of Cyclic Peptides from Pseudostellaria heterophylla [PDF]
MoleculesRadix Pseudostellariae (Tai-Zi-Shen), the dried tuberous root of the Caryophyllaceae plant Pseudostellaria heterophylla (Miq.) Pax (P. heterophylla), has been widely used in traditional Chinese medicine (TCM) for thousands of years. It is slightly bitter,
Yue Yang +6 more
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Small Natural Cyclic Peptides from DBAASP Database [PDF]
PharmaceuticalsAntimicrobial peptides (AMPs) are promising tools for combating microbial resistance. However, their therapeutic potential is hindered by two intrinsic drawbacks—low target affinity and poor in vivo stability.
Evgenia Alimbarashvili +3 more
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Natural Cyclic Peptides: Synthetic Strategies and Biomedical Applications [PDF]
BiomedicinesNatural cyclic peptides, a diverse class of bioactive compounds, have been isolated from various natural sources and are renowned for their extensive structural variability and broad spectrum of medicinal properties.
Devan Buchanan +3 more
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HighFold-MeD: a Rosetta distillation model to accelerate structure prediction of cyclic peptides with backbone N-methylation and d-amino acids [PDF]
Journal of CheminformaticsAbstract Cyclic peptides with backbone N-methylated amino acids (BNMeAAs) and D-amino acids (D-AAs) have gained increasing attention for their stability, membrane permeability, and other therapeutic potentials.
Zhigang Cao +6 more
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Antimicrobial cyclic peptides effectively inhibit multiple forms of Borrelia and cross the blood-brain barrier model [PDF]
Scientific ReportsInfection caused by neuroinvasive Borrelia often manifests long-term CNS disorders and is difficult to treat as most antibiotics fail to attain an effective concentration within the brain or cannot kill the persister forms of Borrelia (cysts and round ...
Evelína Mochnáčová +5 more
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cPEPmatch Webserver: A comprehensive tool and database to aid rational design of cyclic peptides for drug discovery [PDF]
Computational and Structural Biotechnology JournalCyclic peptides have emerged as versatile scaffolds in drug discovery due to their stability and specificity. Here, we present the cPEPmatch webserver (accessible at https://t38webservices.nat.tum.de/cpepmatch/), an easy-to-use interface for the rational
Brianda L. Santini +4 more
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