Results 131 to 140 of about 332,414 (335)

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Superelastic and pH-Responsive Degradable Dendrimer Cryogels Prepared by Cryo-aza-Michael Addition Reaction [PDF]

, 2018
Dendrimers exhibit super atomistic features by virtue of their well-defined discrete quantized nanoscale structures. Here, we show that hyperbranched amine-terminated polyamidoamine (PAMAM) dendrimer G4.0 reacts with linear polyethylene glycol (PEG ...
Wang, Juan, Yang, Hu
core   +3 more sources

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Study on the Effect of Cyclic Loading on the Geomechanics of Sandstone Reservoirs in Gas Storage

International Journal of Chemical Engineering
In the implementation process of carbon capture and storage (CCS), the geomechanical problems arising from the cyclic injection of carbon dioxide into the formation cannot be ignored.
Zhao Xiaolong, Zhao Yizhong, Wang Dongying, Zhao Zhuyu, Deng Yue, Yan Chuanliang, Chen Gang, Liang Wei, Lv Zehao   +8 more
doaj   +1 more source

Non-local energy based fatigue life calculation method under multiaxial variable amplitude loadings [PDF]

, 2013
Reliable design of industrial components against high cycle multiaxial fatigue requires a model capable of predicting both stress gradient and load type effects. Indeed, taking into account gradient effects is of prior importance for the applicability of
BÉNABÈS, Jérôme, COCHETEUX, Francis, PALIN-LUC, Thierry, SAINTIER, Nicolas   +3 more
core   +6 more sources

Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells

FEBS Open Bio, EarlyView.
UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca, Anna Tricarico, Martina Furfaro, Priyam Ghosh, Ennio Prosperi, Lucia Anna Stivala, Ornella Cazzalini   +6 more
wiley   +1 more source

Nonlinear modeling of the cyclic response of RC columns [PDF]

, 2012
Cyclic load reversals (like those induced by earthquakes) result in accelerated bond degradation, leading to significant bar slippage. The bond-slip mechanism is reported to be one of the most common causes of damage and even collapse of existing RC ...
Costa, A., Fernandes, C., Melo, J., Rossetto, T., Varum, H.   +4 more
core   +1 more source

Impact of microstructure, temperature and strain ratio on energy-based low- cycle fatigue life prediction models for TiAl alloys

, 2012
In this paper, two fatigue lifetime prediction models are tested on TiAl intermetallic using results from uniaxial low-cycle fatigue tests. Both assessments are based on dissipated energy but one of them considers a hydrostatic pressure correction.
Gloanec, Anne-Lise, Henaff, Gilbert, Milani, Thomas   +2 more
core   +1 more source

Corrosion Damages Induced by Cyclic Exposure of 2024 Aluminum Alloy in Chloride-Containing Environments [PDF]

, 2011
This paper focuses on the influence of cyclic exposure to chloride solutions on corrosion damage morphology developed on AA2024. The influence of the temperature during the air exposure periods was studied.
Alexis, Joël, Andrieu, Eric, Blanc, Christine, Larignon, Céline, Odemer, Grégory, Salabura, Jean-Claude   +5 more
core   +2 more sources

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source