Cell cycle regulation of a Xenopus Wee1-like kinase [PDF]
, 1995 Using a polymerase chain reaction-based strategy, we have isolated a gene encoding a Wee1-like kinase from Xenopus eggs. The recombinant Xenopus Wee1 protein efficiently phosphorylates Cdc2 exclusively on Tyr- 15 in a cyclin-dependent manner.
Coleman, Thomas R. +2 more
core
Approaches to repurposing reverse transcriptase antivirals in cancer
British Journal of Clinical Pharmacology, EarlyView.This review highlights the role of reverse transcriptase (RT) inhibition in cellular regulation associated with non‐terminal repeat retrotransposons and endogenous retroviruses. Based on their pleiotropic characteristics, RT inhibitors (RTIs) are discussed as potential anticancer agents.
Richard Head +2 more
wiley +1 more source
TGF-β1 Induces the Cyclin-Dependent Kinase Inhibitor p27Kip1 mRNA and Protein in Murine B Cells [PDF]
, 1998 H Kamesaki +4 more
openalex +1 more source
Dynamic protein interactions probed by NMR spectroscopy
Bulletin of the Korean Chemical Society, EarlyView.Abstract Dynamic protein–protein interactions are essential for diverse cellular processes but often evade structural characterization due to their transient, heterogeneous, and disordered nature. This review focuses on how nuclear magnetic resonance (NMR) spectroscopy can provide detailed, residue‐level insights into these complex interactions.
Jaeseok Lee, Jung Ho Lee
wiley +1 more source
Biphasic Regulation of Breast Cancer Cell Growth by Progesterone: Role of the Cyclin-Dependent Kinase Inhibitors, p21 and p27Kip1 [PDF]
, 1997 S. D. Groshong
openalex +1 more source
BMEMat, EarlyView.This review highlights the complex roles of cellular senescence in cancer progression and suppression, discusses the mechanisms and regulatory pathways involved, and evaluates the efficacy of the “One‐Two punch” sequential treatment approach while addressing emerging challenges in this novel therapeutic strategy.
Qiuming Pan +12 more
wiley +1 more source
Suppression of cyclin-dependent kinase 4 during induced differentiation of erythroleukemia cells.
, 1994 Hiroaki Kiyokawa +3 more
openalex +1 more source
Gene Expression and Cell Cycle Arrest Mediated by Transcription Factor DMP1 Is Antagonized by D-Type Cyclins through a Cyclin-Dependent-Kinase-Independent Mechanism [PDF]
, 1998 Kazushi Inoue, Charles J. Sherr
openalex +1 more source
BMEMat, EarlyView.The immunosuppressive tumor microenvironment, characterized by hypoxia, redox imbalance, elevated interstitial fluid pressure, and acidity, was comprehensively elucidated. This review discussed the etiology and consequences of the characteristics of the immunosuppressive tumor microenvironment, and analyzed the recent advancements in nanomaterials for ...
Wen Zhang +7 more
wiley +1 more source
The Yeast Carboxyl-Terminal Repeat Domain Kinase CTDK-I Is a Divergent Cyclin–Cyclin-Dependent Kinase Complex [PDF]
, 1995 David E. Sterner +3 more
openalex +1 more source