Results 181 to 190 of about 386,039 (382)

Discordant expression of the cyclin-dependent kinases and cyclins in rat liver following acute administration of the hepatocarcinogen [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio] acetic acid (WY14,643)

, 1996
Joseph A. Rininger, Geoffrey D. Wheelock, Xinfang Ma, John G. Babish   +3 more
openalex   +1 more source

The link of FOXO1 and FOXO4 transcription factors to development of the lens

Developmental Dynamics, EarlyView.
Abstract Background The FOXOs regulate the transcription of many genes, including ones directly linked to pathways required for lens development. However, this transcription factor family has rarely been studied in the context of development, including the development of the lens.
Rifah N. Gheyas, Ruby C. Williams, Kelly A. Ryan, A. Sue Menko   +3 more
wiley   +1 more source

The history and future of targeting cyclin-dependent kinases in cancer therapy

Nature reviews. Drug discovery, 2015
U. Asghar, A. Witkiewicz, N. Turner, E. Knudsen   +3 more
semanticscholar   +1 more source

Cell-Free Degradation of p27^kip1, a G₁ Cyclin-Dependent Kinase Inhibitor, Is Dependent on CDK2 Activity and the Proteasome

, 1999
Hoang M. Nguyen, Diana M. Gitig, Andrew Koff   +2 more
openalex   +1 more source

The Epstein-Barr virus bZIP transcription factor Zta causes G0/G1 cell cycle arrest through induction of cyclin-dependent kinase inhibitors. [PDF]

, 1996
Corinne Cayrol, Erik K. Flemington
openalex   +1 more source

Update on preclinical models of cancer therapy‐related cardiac dysfunction: Challenges and perspectives. A scientific statement of the Heart Failure Association (HFA) of the ESC, the ESC Council of Cardio‐Oncology, and the ESC Working Group on Cellular Biology of the Heart

European Journal of Heart Failure, EarlyView.
New anticancer therapies with potential cardiovascular side effects are continuously being introduced into clinical practice, with new and often unexpected toxicities becoming apparent only after clinical introduction. These unknown toxicities should be identified and understood beforehand to better prepare patients and physicians, enabling the ...
Alessandra Ghigo, Pietro Ameri, Aarti Asnani, Edoardo Bertero, Rudolf A. de Boer, Dimitrios Farmakis, Arantxa González, Stephane Heymans, Borja Ibáñez, Teresa López‐Fernández, Alexander R. Lyon, Piero Pollesello, Amina Rakisheva, Konstantinos Stellos, Katrin Streckfuss‐Bömeke, Carlo Gabriele Tocchetti, Thomas Thum, Peter van der Meer, Eva Van Rooij, Piotr Ponikowski, Marco Metra, Giuseppe Rosano, Sophie Van Linthout   +22 more
wiley   +1 more source

Gene Expression and Cell Cycle Arrest Mediated by Transcription Factor DMP1 Is Antagonized by D-Type Cyclins through a Cyclin-Dependent-Kinase-Independent Mechanism [PDF]

, 1998
Kazushi Inoue, Charles J. Sherr
openalex   +1 more source

Engineered Exosome‐Based Senolytic Therapy Alleviates Stroke by Targeting p21+CD86+ Microglia

Exploration, EarlyView.
We identified a harmful immune cell type, p21+CD86+ microglia, driving post‐stroke inflammation and developed a targeted exosome‐based therapy (Que@micro‐Exo) to eliminate these cells. This innovative treatment reduced inflammation, alleviated brain damage, and improved recovery in stroke models, offering a promising strategy for stroke and other ...
Jialei Yang, Shipo Wu, Miao He
wiley   +1 more source

Drug design for cyclin-dependent kinase 9 (CDK9) inhibitors <i>in silico</i>. [PDF]

Biochem Biophys Rep
Asamitsu K, Hirokawa T, Okamoto T.
europepmc   +1 more source

Characterization of the cyclin-dependent kinase inhibitory domain of the INK4 family as a model for a synthetic tumour suppressor molecule

, 1998
Robin Fåhræus, Sonia Laı́n, Kathryn L. Ball, David P. Lane   +3 more
openalex   +1 more source