Results 221 to 230 of about 518,198 (339)

The role of cyclin dependent kinase 2 (Cdk2) in the proliferation and differentiation of pluripotent embryonic stem cells / Elaine B. Stead.

, 2002
Elaine Stead
openalex   +1 more source

The history and future of targeting cyclin-dependent kinases in cancer therapy

Nature reviews. Drug discovery, 2015
U. Asghar, A. Witkiewicz, N. Turner, E. Knudsen   +3 more
semanticscholar   +1 more source

CRISPR Enabled Precision Oncology: From Gene Editing to Tumor Microenvironment Remodeling

Med Research, EarlyView.
CRISPR technology has progressed from a prokaryotic immune system to a diverse suite of editing platforms, including Cas nucleases, base and prime editors, and RNA‐targeting enzymes. These advances enable precise genomic and epigenomic interventions, high‐throughput functional screening, and immune engineering.
Kailai Li, Peixin Huang, Yue Qian, Anqi Lin, Jingjun He, Junyi Shen, Li Chen, Kai Miao, Jian Zhang   +8 more
wiley   +1 more source

Combination of cyclin-dependent kinase 4/6 inhibitors and renin-angiotensin system inhibitors in breast cancer treatment: a promising therapeutic approach. [PDF]

Rev Assoc Med Bras (1992)
Mutlu E, İnanç M.
europepmc   +1 more source

Author response: Knockout of cyclin dependent kinases 8 and 19 leads to depletion of cyclin C and suppresses spermatogenesis and male fertility in mice

Alexandra V. Bruter, Ekaterina A. Varlamova, Nina I Stavskaya, Zoya Antysheva, В. Н. Манских, Anna V. Tvorogova, Diana S. Korshunova, Alvina I. Khamidullina, Marina Utkina, Viktor P. Bogdanov, Julia Baikova, Alyona I. Nikiforova, Eugene A Albert, Denis Maksimov, Jing Li, Mengqian Chen, Gary P. Schools, А. В. Феоктистов, Аlexander А. Shtil, Igor B. Roninson, Vladic Mogila, Yulia Yu. Silaeva, Victor V. Tatarskiy   +22 more
openalex   +1 more source

The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches

Medicinal Research Reviews, EarlyView.
ABSTRACT A plethora of cellular signaling pathways are dysregulated in cancer cells, promoting carcinogenesis and migration. Cholesterol has recently been linked to cancer by several subcellular mechanisms, especially by its involvement in the formation of lipid rafts, which promote oncogenic signaling and cancer cell invasion. Squalene synthase (SQS),
Danai Mavridi, Theodora Katavati, Angeliki P. Kourounakis   +2 more
wiley   +1 more source

An investigation on Alzheimer's disease with obstructive sleep apnea: alterations of cognitive function, roles of cyclin-dependent kinase 5 and changes of brain structure. [PDF]

Front Aging Neurosci
Luo D, Lian T, Wei N, Guo P, He M, Zhang Y, Huang Y, Liu G, Li J, Li J, Qi J, Guan H, Zhang W, Zhang W, Zheng Z, Yue H, Liu Z, Zhang F, Meng Y, Zhang W.   +19 more
europepmc   +1 more source

Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism.

Proceedings of the National Academy of Sciences of the United States of America, 1995
M. Datto, Yan Li, J. Panus, David J. Howe, Y. Xiong, Xiao-Fan Wang   +5 more
semanticscholar   +1 more source

Human Cyclophilins—An Emerging Class of Drug Targets

Medicinal Research Reviews, EarlyView.
ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova, Hana Navratilova, Kamil Musilek, Ondrej Benek   +3 more
wiley   +1 more source

Pan-cyclin-dependent kinase inhibition is a potential treatment for adenoid cystic carcinoma that downregulates the MYB::NFIB fusion and induces tumor regression. [PDF]

Cancer Commun (Lond)
Huang J, Larsson P, Kakay Afshari M, Tejera Nevado P, Tešan Tomić T, Fehr A, Jäwert F, Stenman G, Andersson MK.   +8 more
europepmc   +1 more source