Results 301 to 310 of about 386,039 (382)

The role of FDG PET assessment in patients with advanced breast cancer treated with cyclin-dependent kinase 4/6 inhibitors in the second-line setting. [PDF]

Front Oncol
Kubeczko M, Polakiewicz-Gilowska A, D'Amico A, Chrabański O, Świderska K, Chmielik E, Blamek S, Handkiewicz-Junak D, Jarząb M.   +8 more
europepmc   +1 more source

Effect of Cyclin-Dependent Kinase 4/6 Inhibitors on Circulating Cells in Patients with Metastatic Breast Cancer. [PDF]

Cells
Lobo-Martins S, Corredeira P, Cavaco A, Rodrigues C, Piairo P, Lopes C, Fraga J, Silva M, Alves P, Wachholz Szeneszi L, Barradas A, Castro Duran C, Antunes M, Nogueira-Costa G, Sousa R, Pinto C, Ribeiro L, Abreu C, Torres S, Quintela A, Mata G, Megías D, Ribot J, Serre K, Casimiro S, Silva-Santos B, Diéguez L, Costa L.   +27 more
europepmc   +1 more source

Potent estrogen receptor β agonists with inhibitory activity <i>in vitro</i>, fail to suppress xenografts of endocrine-resistant cyclin-dependent kinase 4/6 inhibitor-resistant breast cancer cells. [PDF]

Front Oncol
Marcho LM, Coss CC, Xu M, Datta J, Manouchehri JM, Cherian MA.   +5 more
europepmc   +1 more source

Association between cyclin-dependent kinase 4/6 inhibitors and nephrotoxicity in patients with breast cancer: A Systematic Review and meta-analysis. [PDF]

iScience
Cui J, Sun J, Zhou X, Li Y, Zhao J, Shen G.   +5 more
europepmc   +1 more source

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Targets of the cyclin-dependent kinase Cdk1

Nature, 2003
The events of cell reproduction are governed by oscillations in the activities of cyclin-dependent kinases (Cdks). Cdks control the cell cycle by catalysing the transfer of phosphate from ATP to specific protein substrates. Despite their importance in cell-cycle control, few Cdk substrates have been identified.
Jeffrey A. Ubersax, Erika L. Woodbury, Erika L. Woodbury, Kavita Shah, Kevan M. Shokat, Phuong N. Quang, Phuong N. Quang, Justin D. Blethrow, Justin D. Blethrow, David O. Morgan, David O. Morgan, Maria Paraz, Maria Paraz   +12 more
openaire   +4 more sources

Cyclin-dependent kinase inhibitors.

Progress in cell cycle research, 2003
Cyclin-dependent kinases are involved in diverse cellular processes that include cell cycle control, apoptosis, neuronal physiology, differentiation, and transcription. Intensive screening and drug design based on CDK/inhibitor co-crystal structures and on SAR studies have led to the identification and characterization of a large variety of chemical ...
P. M., Fischer, Endicott, J., Meijer, L.
openaire   +7 more sources

Cyclin-Dependent Kinase 2 Inhibitors in Cancer Therapy: An Update.

Journal of Medicinal Chemistry, 2018
Cyclin-dependent kinase 2 (CDK2) drives the progression of cells into the S- and M-phases of the cell cycle. CDK2 activity is largely dispensable for normal development, but it is critically associated with tumor growth in multiple cancer types. Although
S. Tadesse, E. Caldon, W. Tilley, Shudong Wang   +3 more
semanticscholar   +1 more source

Cdk Pathway: Cyclin-Dependent Kinases and Cyclin-Dependent Kinase Inhibitors

Molecular Biotechnology, 2001
Many mechanisms either activate or inhibit the cdks and thereby either promote or arrest progression through the mitotic cell cycle. Since the signal transduction pathways emanating from extracellular mitogens and the agents controlling these pathways are complicated there may yet be novel mechanisms of cell cycle regulation remaining to be elucidated.
Diana M. Gitig, Diana M. Gitig, Andrew Koff, Andrew Koff   +3 more
openaire   +4 more sources

Cyclin‐Dependent Kinase 12, Immunity, and Prostate Cancer

New England Journal of Medicine, 2018
Prostate Cancer and Checkpoint Inhibition Somatic inactivating variants in the gene CDK12, encoding cyclin-dependent kinase 12, generate fusion-induced neoantigens in prostate cancer.
E. Antonarakis
semanticscholar   +1 more source

Mammalian cyclin-dependent kinases

Trends in Biochemical Sciences, 2005
Cyclin-dependent kinases (Cdks) are the catalytic subunits of a family of mammalian heterodimeric serine/threonine kinases that have been implicated in the control of cell-cycle progression, transcription and neuronal function. Recent genetic evidence obtained with gene-targeted mice has shown that Cdk4 and Cdk6 are not needed for entry into the cell ...
Mariano Barbacid, Marcos Malumbres
openaire   +3 more sources