Results 301 to 310 of about 504,196 (405)

Influence of ethnicity on cyclin-dependent kinase inhibitor efficacy and toxicity: A systematic review and meta-analysis. [PDF]

Breast
Buonaiuto R, Caltavituro A, Tafuro M, Longobardi A, Pavone G, De Santis P, Caputo R, De Angelis C, Del Mastro L, Puglisi F, Giuliano M, Arpino G, Pagliuca M, De Laurentiis M.   +13 more
europepmc   +1 more source

Intermittent Supplementation With Fisetin Improves Physical Function and Decreases Cellular Senescence in Skeletal Muscle With Aging: A Comparison to Genetic Clearance of Senescent Cells and Synthetic Senolytic Approaches

Aging Cell, EarlyView.
Supplementation with the natural senolytic agent fisetin attenuated age‐related declines in physical function in mice. Better physical function with fisetin was accompanied by lower expression of cell senescence‐related genes. Fisetin treatment had comparable effects on physical function as genetic clearance of senescent cells and synthetic senolytic ...
Kevin O. Murray, Sophia A. Mahoney, Katelyn R. Ludwig, Jill H. Miyamoto‐Ditmon, Nicholas S. VanDongen, Nirad Banskota, Allison B. Herman, Douglas R. Seals, Robert T. Mankowski, Matthew J. Rossman, Zachary S. Clayton   +10 more
wiley   +1 more source

Is Adjuvant Chemotherapy Preceding Cyclin-Dependent Kinase 4/6 Inhibitor Therapy Beneficial? [PDF]

J Breast Cancer
Sorscher S.
europepmc   +1 more source

Biomarkers of Cellular Senescence in Type 2 Diabetes Mellitus

Aging Cell, EarlyView.
In cohorts of lean controls, obese participants without Type 2 Diabetes Mellitus (T2DM) and obese T2DM participants, we find that T‐cell expression of senescence biomarkers is altered only in the T2DM participants and not with obesity alone. Moreover, high T‐cell p16 expression in the T2DM participants is associated with impaired bone cortical indices.
Caroline Hoong, Joshua N. Farr, David G. Monroe, Thomas A. White, Elizabeth J. Atkinson, Amanda Tweed, Allyson K. Palmer, Nathan K. LeBrasseur, Jad G. Sfeir, Sundeep Khosla   +9 more
wiley   +1 more source

Short‐Term Severe Energy Restriction Promotes Molecular Health and Reverses Aging Signatures in Adults With Prediabetes in the PREVIEW Study

Aging Cell, EarlyView.
Severe short‐term energy restriction in adults with prediabetes led to a significant reduction in circulating proteins linked to inflammation, senescence, and protein turnover. These changes, partly mediated by extracellular vesicles, suggest systemic dietary‐induced benefits beyond glycemic control, including improved aging biomarkers.
Maria Lastra Cagigas, Andrius Masedunskas, Yao Lin, Samantha J. Emery‐Corbin, Jumana M. Yousef, Laura F. Dagley, Sam Olechnowicz, Rory Bowden, Rachael Hayward, Gary Low, Roslyn Muirhead, Jennie Brand‐Miller, Mikael Fogeltholm, Anne Raben, Marco Demaria, Stephen J. Fuller, Luigi Fontana   +16 more
wiley   +1 more source

Efficacy of cyclin-dependent kinase inhibitors with concurrent proton pump inhibitors in patients with breast cancer: a systematic review and meta-analysis. [PDF]

Oncologist
Guo Z, Zhu Z, Luo M, Cao Y, Lin X, Wu Q, Wang S, Wang L, Zhou J.   +8 more
europepmc   +1 more source

Virus‐Induced Cellular Senescence Causes Pulmonary Sequelae Post‐Influenza Infection

Aging Cell, EarlyView.
Genetic or pharmacological depletion of senescent cells during influenza A virus infection led to complete recovery of the airway epithelium, indicating a marked acceleration of the epithelial repair process. Targeting senescent cells may represent a new preventive therapeutic option to reduce post‐influenza chronic lung damage.
Larissa Lipskaia, Lou Delval, Valentin Sencio, Emmanuelle Born, Séverine Heumel, Amal Houssaini, Clara Valentin, Stefano Raviola, Lucie Deruyter, Fabiola Silva Angulo, Vincent Gros, Elisabeth Marcos, Shariq Abid, Mira Goekyildirim, Vanessa Contreras, Jean Michel Flaman, Roger Le Grand, Ronan Le Goffic, David Bernard, Serge Adnot, François Trottein   +20 more
wiley   +1 more source

Crosslink among cyclin-dependent kinase 9, ATP binding cassette transporter G2 and Beclin 1 in colorectal cancer. [PDF]

World J Gastrointest Oncol
Shao ZB, He K, Su YB, Shi Z.
europepmc   +1 more source

BubR1 Insufficiency Drives Transcriptomic Alterations and Pathology Associated With Cardiac Aging and Heart Failure

Aging Cell, EarlyView.
Transcriptomic and cellular analyses of BubR1 hypomorphic hearts reveal disruptions in key pathways and upregulation of markers linked to impaired cardiac structure and function. Comparative transcriptomic analysis shows that BubR1 insufficiency mirrors changes seen in aged and failing hearts. A key finding of this study is that BubR1 levels decline in
Renju Pun, Aliya L. Haas, Aradhana Thapa, Sylar R. Takafuji, Rexton M. Suzuki, Gabrielle F. Kay, Li Zheng, Michelle Waknitz, Michael H. Kim, Darren J. Baker, Jan M. van Deursen, Paul L. Sorgen, Rebekah L. Gundry, Brian J. North   +13 more
wiley   +1 more source

Palbociclib-induced Toxic Epidermal Necrolysis: A Case Report with Review of All Cases Secondary to Cyclin-dependent Kinase 4/6 Inhibitors. [PDF]

Acta Derm Venereol
Devoldere A, Vanhaecke C, Soibinet P, Azzouz B, Viguier M.   +4 more
europepmc   +1 more source