Results 41 to 50 of about 518,198 (339)

Xenopus NM23-X4 regulates retinal gliogenesis through interaction with p27Xic1 [PDF]

, 2009
Background. In Xenopus retinogenesis, p27Xic1, a Xenopus cyclin dependent kinase inhibitor, functions as a cell fate determinant in both gliogenesis and neurogenesis in a context dependent manner.
Aikaterini Bilitou, Caroline T Waters, Kamran Hussain, Massimo Zollo, Mochizuki, Toshiaki, Shin-ichi Ohnuma, Toshiaki Mochizuki   +6 more
core   +3 more sources

Cyclin-dependent kinase control of motile ciliogenesis

eLife, 2018
Cycling cells maintain centriole number at precisely two per cell in part by limiting their duplication to S phase under the control of the cell cycle machinery.
Eszter K Vladar, Miranda B Stratton, Maxwell L Saal, Glicella Salazar-De Simone, Xiangyuan Wang, Debra Wolgemuth, Tim Stearns, Jeffrey D Axelrod   +7 more
doaj   +1 more source

Cascades of multisite phosphorylation control Sic1 destruction at the onset of S phase. [PDF]

, 2011
Multisite phosphorylation of proteins has been proposed to transform a graded protein kinase signal into an ultrasensitive switch-like response. Although many multiphosphorylated targets have been identified, the dynamics and sequence of individual ...
Balog, Eva Rose M, Iofik, Anna, Kõivomägi, Mardo, Lepiku, Martin, Loog, Mart, Morgan, David O, Rubin, Seth M, Valk, Ervin, Venta, Rainis   +8 more
core   +2 more sources

Effect of vorinostat on INK4 family and HDACs 1, 2, and 3 in pancreatic cancer and hepatocellular carcinoma

Research in Pharmaceutical Sciences, 2021
Background and purpose: In mammalian cells, several distinct surveillance systems, named cell cycle checkpoints, can interrupt normal cell-cycle progression.
Masumeh Sanaei, Fraidoon Kavoosi
doaj   +1 more source

Inhibition of cyclin-dependent kinase 7 down-regulates yes-associated protein expression in mesothelioma cells. [PDF]

, 2020
Cyclin-dependent kinase 7 (CDK7) is a protein kinase that plays a major role in transcription initiation. Yes-associated protein (YAP) is a main effector of the Hippo/YAP signalling pathway.
Bin, Hu, Chan, Geraldine, Jablons, David M, Kyoyama, Hiroyuki, Li, Hui, Liu, Luwei, Liu, Shu, Miao, Jinbai, Urisman, Anatoly, Wang, Yucheng, Xu, Zhidong, Yang, Yi-Lin, You, Liang   +12 more
core  

Morphological analysis of CDC2 and glycogen synthase kinase 3β phosphorylation as markers of g2 → m transition in glioma. [PDF]

, 2011
G2 → M transition is a strategic target for glioma chemotherapy. Key players in G2 → M transition include CDC2 and glycogen synthase kinase 3β (GSK3β), which are highly regulated by posttranslational phosphorylation.
Otero, José Javier, Tihan, Tarik
core   +3 more sources

Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4.

Genes & Development, 1993
The product (pRb) of the retinoblastoma gene (RB-1) prevents S-phase entry during the cell cycle, and inactivation of this growth-suppressive function is presumed to result from pRb hyperphosphorylation during late G1 phase.
J. Kato, H. Matsushime, S. Hiebert, M. Ewen, C. Sherr   +4 more
semanticscholar   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Cyclin-dependent kinase inhibitors: efficacy and safety

Медицинский совет, 2019
Breast Cancer is the most common type of cancer worldwide. Scientific advances and new ways of treating have significantly improved the prognosis of breast cancer in recent decades.
I. B. Kononenko, A. V. Snegovoi, V. Yu. Selchuk   +2 more
doaj   +1 more source

TORC1 coordinates the conversion of Sic1 from a target to an inhibitor of cyclin-CDK-Cks1 [PDF]

, 2017
Eukaryotic cell cycle progression through G1–S is driven by hormonal and growth- related signals that are transmitted by the target of rapamycin complex 1 (TORC1) pathway.
Jaquenoud, Malika, Moreno-Torres, Marta, Nicastro, Raffaele, Péli-Gulli, Marie-Pierre, Virgilio, Claudio De   +4 more
core   +2 more sources