Results 41 to 50 of about 504,196 (405)

TORC1 coordinates the conversion of Sic1 from a target to an inhibitor of cyclin-CDK-Cks1 [PDF]

, 2017
Eukaryotic cell cycle progression through G1–S is driven by hormonal and growth- related signals that are transmitted by the target of rapamycin complex 1 (TORC1) pathway.
Jaquenoud, Malika, Moreno-Torres, Marta, Nicastro, Raffaele, Péli-Gulli, Marie-Pierre, Virgilio, Claudio De   +4 more
core   +1 more source

Cyclin-dependent kinases: a family portrait [PDF]

Nature Cell Biology, 2009
To the Editor, Cyclin-dependent kinases (CDKs) are protein kinases involved in critical cellular processes, such as cell cycle or transcription, whose activity requires association with specific cyclin subunits. Based on sequence similarity, the human genome contains 21 genes encoding CDKs and five additional genes encoding a more distant group of ...
Tony Hunter, Debra J. Wolgemuth, Tim Hunt, Jill M. Lahti, David O. Morgan, Li-Huei Tsai, Marcos Malumbres, Gerard Manning, Ed Harlow   +8 more
openaire   +3 more sources

mTORC1 Down-Regulates Cyclin-Dependent Kinase 8 (CDK8) and Cyclin C (CycC). [PDF]

PLoS ONE, 2015
In non-alcoholic fatty liver disease (NAFLD) and insulin resistance, hepatic de novo lipogenesis is often elevated, but the underlying mechanisms remain poorly understood. Recently, we show that CDK8 functions to suppress de novo lipogenesis.
Daorong Feng, Dou Yeon Youn, Xiaoping Zhao, Yanguang Gao, William J Quinn, Alus M Xiaoli, Yan Sun, Morris J Birnbaum, Jeffrey E Pessin, Fajun Yang   +9 more
doaj   +1 more source

Effect of vorinostat on INK4 family and HDACs 1, 2, and 3 in pancreatic cancer and hepatocellular carcinoma

Research in Pharmaceutical Sciences, 2021
Background and purpose: In mammalian cells, several distinct surveillance systems, named cell cycle checkpoints, can interrupt normal cell-cycle progression.
Masumeh Sanaei, Fraidoon Kavoosi
doaj   +1 more source

Bifurcation analysis of a model of the budding yeast cell cycle

, 2004
We study the bifurcations of a set of nine nonlinear ordinary differential equations that describe the regulation of the cyclin-dependent kinase that triggers DNA synthesis and mitosis in the budding yeast, Saccharomyces cerevisiae.
Battogtokh, Dorjsuren, Tyson, John J.
core   +1 more source

The cyclin-dependent kinase inhibitor p57(Kip2) is epigenetically regulated in carboplatin resistance and results in collateral sensitivity to the CDK inhibitor seliciclib in ovarian cancer [PDF]

, 2012
Carboplatin remains a first-line agent in the management of epithelial ovarian cancer (EOC). Unfortunately, platinum-resistant disease ultimately occurs in most patients.
A Bali, C Beretta, D P Lovell, E Papacharalbous, E Rosenberg, G D’Andrilli, H M Coley, HM Coley, I-S Song, K Madhuri, MA Levesque, N A M Safuwan, N Syed, N Syed, P Chivers, P Vlachos, P Zhang, PS Larson, RM Glasspool, S Butler-Manuel, SH Wei, ST Kim, T Crook, T Giannopoulos, T Kobatake, V Masciullo, W Roeb, Y Ma   +27 more
core   +1 more source

Signalling, cell cycle and pluripotency in embryonic stem cells [PDF]

, 2002
International ...
Burdon, Tom, Savatier, Pierre, Smith, Austin   +2 more
core   +1 more source

Cyclin-dependent kinase inhibitors: efficacy and safety

Медицинский совет, 2019
Breast Cancer is the most common type of cancer worldwide. Scientific advances and new ways of treating have significantly improved the prognosis of breast cancer in recent decades.
I. B. Kononenko, A. V. Snegovoi, V. Yu. Selchuk   +2 more
doaj   +1 more source

The emerging roles and therapeutic potential of cyclin-dependent kinase 11 (CDK11) in human cancer. [PDF]

, 2016
Overexpression and/or hyperactivation of cyclin-dependent kinases (CDKs) are common features of most cancer types. CDKs have been shown to play important roles in tumor cell proliferation and growth by controlling cell cycle, transcription, and RNA ...
Duan, Zhenfeng, Hornicek, Francis J, Kan, Quancheng, Shen, Jacson K, Zhou, Yubing   +4 more
core   +1 more source

Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4.

Genes & Development, 1993
The product (pRb) of the retinoblastoma gene (RB-1) prevents S-phase entry during the cell cycle, and inactivation of this growth-suppressive function is presumed to result from pRb hyperphosphorylation during late G1 phase.
J. Kato, H. Matsushime, S. Hiebert, M. Ewen, C. Sherr   +4 more
semanticscholar   +1 more source