Results 61 to 70 of about 383,210 (284)

Cyclin-dependent kinase inhibitor therapy for hematologic malignancies

Expert Opinion on Investigational Drugs, 2013
Introduction: Cyclin-dependent kinases (CDKs) regulate cell cycle progression. Certain CDKs (e.g., CDK7, CDK9) also control cellular transcription.
P. Bose, G. Simmons, S. Grant
semanticscholar   +1 more source

Bifurcation analysis of a model of the budding yeast cell cycle [PDF]

, 2004
We study the bifurcations of a set of nine nonlinear ordinary differential equations that describe the regulation of the cyclin-dependent kinase that triggers DNA synthesis and mitosis in the budding yeast, Saccharomyces cerevisiae. We show that Clb2-dependent kinase exhibits bistability (stable steady states of high or low kinase activity).
arxiv   +1 more source

Cytomegalovirus cyclin-dependent kinase ortholog vCDK/pUL97 undergoes regulatory interaction with human cyclin H and CDK7 to codetermine viral replication efficiency

Virus Research, 2023
Human cytomegalovirus (HCMV) infection is shaped by a tightly regulated interplay between viral and cellular proteins. Distinct kinase activities, such as the viral cyclin-dependent kinase ortholog (vCDK) pUL97 and cellular CDK7 are both crucial for ...
Martin Schütz, Christina Wangen, Mona Sommerer, Melanie Kögler, Jan Eickhoff, Carsten Degenhart, Bert Klebl, Zin Naing, Ece Egilmezer, Stuart T. Hamilton, William D. Rawlinson, Heinrich Sticht, Manfred Marschall   +12 more
doaj  

Cell Cycle Regulation in the Plant Response to Stress

Frontiers in Plant Science, 2020
As sessile organisms, plants face a variety of environmental challenges. Their reproduction and survival depend on their ability to adapt to these stressors, which include water, heat stress, high salinity, and pathogen infection.
Feifei Qi, Fuxin Zhang
doaj   +1 more source

Speeding through cell cycle roadblocks: Nuclear cyclin D1-dependent kinase and neoplastic transformation

Cell Division, 2008
Mitogenic induction of cyclin D1, the allosteric regulator of CDK4/6, is a key regulatory event contributing to G1 phase progression. Following the G1/S transition, cyclin D1 activation is antagonized by GSK3β-dependent threonine-286 (Thr-286 ...
Diehl J Alan, Pontano Laura L
doaj   +1 more source

A complex role of Arabidopsis CDKD;3 in meiotic progression and cytokinesis

Plant Direct, 2023
Meiosis is a specialized cell division that halves the number of chromosomes in two consecutive rounds of chromosome segregation. In angiosperm plants is meiosis followed by mitotic divisions to form rudimentary haploid gametophytes.
Sorin Tanasa, Neha Shukla, Albert Cairo, Ranjani S. Ganji, Pavlina Mikulková, Sona Valuchova, Vivek K. Raxwal, Claudio Capitao, Arp Schnittger, Zbyněk Zdráhal, Karel Riha   +10 more
doaj   +1 more source

Identification of abemaciclib derivatives targeting cyclin-dependent kinase 4 and 6 using molecular dynamics, binding free energy calculation, synthesis, and pharmacological evaluation

Frontiers in Pharmacology, 2023
CDK4/6 plays a crucial role in various cancers and is an effective anticancer drug target. However, the gap between clinical requirements and approved CDK4/6 drugs is unresolved.
Yanting Zhou, Xiandeng Li, Peifang Luo, Huiting Chen, Yan Zhou, Xueting Zheng, Yuan Yin, Haoche Wei, Hongji Liu, Wen Xia, Mingsong Shi, Xiaoan Li   +11 more
doaj   +1 more source

Cyclin-dependent kinase 1 (Cdk1) is essential for cell division and suppression of DNA re-replication but not for liver regeneration

Proceedings of the National Academy of Sciences of the United States of America, 2012
Cyclin-dependent kinase 1 (Cdk1) is an archetypical kinase and a central regulator that drives cells through G2 phase and mitosis. Knockouts of Cdk2, Cdk3, Cdk4, or Cdk6 have resulted in viable mice, but the in vivo functions of Cdk1 have not been fully ...
M. K. Diril, Chandrahas Koumar Ratnacaram, V. Padmakumar, Tiehua Du, M. Wasser, V. Coppola, L. Tessarollo, P. Kaldis   +7 more
semanticscholar   +1 more source

Cyclin-Dependent Kinase Suppression by WEE1 Kinase Protects the Genome through Control of Replication Initiation and Nucleotide Consumption

Molecular and Cellular Biology, 2012
Activation of oncogenes or inhibition of WEE1 kinase deregulates cyclin-dependent kinase (CDK) activity and leads to replication stress; however, the underlying mechanism is not understood. We now show that elevation of CDK activity by inhibition of WEE1
Halfdan Beck, Viola Nähse-Kumpf, M. S. Y. Larsen, K. O’Hanlon, S. Patzke, Christian Holmberg, Jakob Mejlvang, Anja Groth, O. Nielsen, R. Syljuåsen, C. Sørensen   +10 more
semanticscholar   +1 more source

Role for non-proteolytic control of M-phase-promoting factor activity at M-phase exit.

PLoS ONE, 2007
M-phase Promoting Factor (MPF; the cyclin B-cdk 1 complex) is activated at M-phase onset by removal of inhibitory phosphorylation of cdk1 at thr-14 and tyr-15. At M-phase exit, MPF is destroyed by ubiquitin-dependent cyclin proteolysis.
Vincenzo D'Angiolella, Luca Palazzo, Concetta Santarpia, Vincenzo Costanzo, Domenico Grieco   +4 more
doaj   +1 more source