Seliciclib (CYC202 or R-roscovitine), a small-molecule cyclin-dependent kinase inhibitor, mediates activity via down-regulation of Mcl-1 in multiple myeloma [PDF]
, 2005 Noopur Raje +10 more
openalex +1 more source
Engineered Exosome‐Based Senolytic Therapy Alleviates Stroke by Targeting p21+CD86+ Microglia
Exploration, EarlyView.We identified a harmful immune cell type, p21+CD86+ microglia, driving post‐stroke inflammation and developed a targeted exosome‐based therapy (Que@micro‐Exo) to eliminate these cells. This innovative treatment reduced inflammation, alleviated brain damage, and improved recovery in stroke models, offering a promising strategy for stroke and other ...
Jialei Yang, Shipo Wu, Miao He
wiley +1 more source
MiR‐29a/b Suppresses CD8+ T Cell Effector Function and Intestinal Inflammation
Exploration, EarlyView.Our findings suggest that miR‐29a/b is a critical regulator of CD8+ T cells, possibly via the Ifng‐JAK‐STAT signal in IBD patients and the upregulation of miR‐29a/b relieves the development of significant inflammation in the colon of DSS‐induced colitis‐affected mice.
Yingying Lin +27 more
wiley +1 more source
Inhibition of Cyclin-dependent Kinase 1 Induces Cytokinesis without Chromosome Segregation in an ECT2 and MgcRacGAP-dependent Manner [PDF]
, 2005 Fumihiko Niiya +4 more
openalex +1 more source
Phosphorylation of Protein Phosphatase 1 by Cyclin-dependent Protein Kinase 5 during Nerve Growth Factor-induced PC12 Cell Differentiation [PDF]
, 2007 Tong Li +2 more
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microRNA-769 is Downregulated in Colorectal Cancer and Inhibits Cancer Progression by Directly Targeting Cyclin-Dependent Kinase 1 [Retraction]. [PDF]
Onco Targets Ther, 2021 europepmc +1 more source
Somatic cell reprogramming for Parkinson's disease treatment
Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley +1 more source
Cyclin-Dependent Kinase 1/Cyclin B1 Phosphorylates Varicella-Zoster Virus IE62 and Is Incorporated into Virions [PDF]
, 2008 Stacey A. Leisenfelder +2 more
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Navigating the treatment landscape of Alzheimer's disease: Current strategies and future directions
Ibrain, EarlyView.Alzheimer's disease treatment is evolving rapidly, with emerging strategies targeting multiple disease pathways. This graphical abstract highlights the shift from traditional therapies to innovative approaches that hold promise for improving outcomes.
Tapas Kumar Mohapatra +4 more
wiley +1 more source