Results 251 to 260 of about 384,579 (349)

Androgen receptor phosphorylation and stabilization in prostate cancer by cyclin-dependent kinase 1

Proceedings of the National Academy of Sciences of the United States of America, 2006
Shaoyong Chen, Youyuan Xu, Xin Yuan, G. Bubley, S. Balk   +4 more
semanticscholar   +1 more source

Loganin, an Iridoid Glycoside, Alleviates Paclitaxel‐Induced Skeletal Muscle Toxicity by Enhancing Mitochondrial Function, Boosting Antioxidant Defenses, and Reducing Cellular Senescence

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Mitochondrial dysfunction and energy imbalance caused by chemotherapy are key contributors to skeletal muscle atrophy, which severely impacts the quality of life in cancer patients. Paclitaxel, a commonly used chemotherapeutic agent, is known to promote muscle wasting and cellular senescence, largely by impairing mitochondrial function.
Yu‐Fan Chuang, Cai‐Rong Wu, Wan‐Hsuan Chang, Ying‐Jung Su, Hung‐Te Hsu, Fan‐Li Lin, Yi‐Ching Lo   +6 more
wiley   +1 more source

RTA‐408 Enhances Radiosensitivity and Inhibited Tumor Progression via JNK Pathway in Glioblastoma

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Glioblastoma (GBM) is an aggressive brain tumor with poor prognosis owing to its high invasiveness and resistance to therapy. RTA‐408, a synthetic triterpenoid and nuclear factor erythroid 2‐related factor 2 activator, exhibits anti‐inflammatory and anti‐cancer properties; however, its effects on GBM remain unclear. This study investigated the
Hung‐Pei Tsai, Hao Qin, Yoon Bin Chong, I‐Hsiang Chen, Shih‐Hsun Kuo, Tzu‐Ting Tseng, Ann‐Shung Lieu   +6 more
wiley   +1 more source

Protein glycosylation in lung cancer from a mass spectrometry perspective

Mass Spectrometry Reviews, EarlyView.
Abstract Lung cancer is a severe disease for which better diagnostic and therapeutic approaches are urgently needed. Increasing evidence implies that aberrant protein glycosylation plays a crucial role in the pathogenesis and progression of lung cancer.
Mirjam Balbisi, Simon Sugár, Lilla Turiák   +2 more
wiley   +1 more source

Reviewer #1 (Public Review): Cyclin-dependent kinase 5 (Cdk5) activity is modulated by light and gates rapid phase shifts of the circadian clock [PDF]

Andrea Brenna, Micaela Borsa, Gabriella Saro, Jürgen A. Ripperger, Dominique A. Glauser, Zhihong Yang, Antoine Adamantidis, Urs Albrecht   +7 more
openalex   +2 more sources

Supplementary Annex 1 from Cyclin-Dependent Kinase 2/Cyclin E Complex Is Involved in p120 Catenin (p120ctn)–Dependent Cell Growth Control: A New Role for p120ctn in Cancer

, 2023
Nicolas T. Chartier, Christiane Oddou, Michèle G. Lainé, Benjamin Ducarouge, Christiane A. Marie, Marc R. Block, Muriel R. Jacquier‐Sarlin   +6 more
openalex   +1 more source

Cyclin-Dependent Kinase 1-Mediated Bcl-xL/Bcl-2 Phosphorylation Acts as a Functional Link Coupling Mitotic Arrest and Apoptosis

Molecular and Cellular Biology, 2009
D. Terrano, M. Upreti, T. Chambers
semanticscholar   +1 more source

CRISPR Enabled Precision Oncology: From Gene Editing to Tumor Microenvironment Remodeling

Med Research, EarlyView.
CRISPR technology has progressed from a prokaryotic immune system to a diverse suite of editing platforms, including Cas nucleases, base and prime editors, and RNA‐targeting enzymes. These advances enable precise genomic and epigenomic interventions, high‐throughput functional screening, and immune engineering.
Kailai Li, Peixin Huang, Yue Qian, Anqi Lin, Jingjun He, Junyi Shen, Li Chen, Kai Miao, Jian Zhang   +8 more
wiley   +1 more source

The Photorhabdus Virulence Cassettes RRSP-Like Effector Interacts With Cyclin-Dependent Kinase 1 and Causes Mitotic Defects in Mammalian Cells. [PDF]

Front Microbiol, 2020
Wang X, Shen J, Jiang F, Jin Q.
europepmc   +1 more source

Discovery of [4-Amino-2-(1-methanesulfonylpiperidin-4-ylamino)pyrimidin-5-yl](2,3-difluoro-6- methoxyphenyl)methanone (R547), A Potent and Selective Cyclin-Dependent Kinase Inhibitor with Significant in Vivo Antitumor Activity

, 2006
Xin‐Jie Chu, Wanda DePinto, David Bartkovitz, Sung-Sau So, Binh Thanh Vu, Kathryn Packman, Christine Lukacs, Qingjie Ding, Nan Jiang, Ka Wang, Petra Goelzer, Xuefeng Yin, Melissa Smith, Brian X. Higgins, Yingsi Chen, Qing Xiang, John Moliterni, Gerald L. Kaplan, Bradford Graves, Allen Lovey, Nader Fotouhi   +20 more
openalex   +1 more source