Results 1 to 10 of about 338,090 (224)

Cyclin-dependent kinase 5 (CDK5) regulates the circadian clock [PDF]

eLife, 2019
Circadian oscillations emerge from transcriptional and post-translational feedback loops. An important step in generating rhythmicity is the translocation of clock components into the nucleus, which is regulated in many cases by kinases.
Andrea Brenna, Iwona Olejniczak, Rohit Chavan, Jürgen A Ripperger, Sonja Langmesser, Elisabetta Cameroni, Zehan Hu, Claudio De Virgilio, Jörn Dengjel, Urs Albrecht   +9 more
doaj   +6 more sources

Targeting the cyclin-dependent kinase 5 in metastatic melanoma. [PDF]

Proc Natl Acad Sci U S A, 2020
Significance Melanomas are notorious due to their propensity to form lethal metastases. Currently, no treatments are available to stop the metastatic spread.
Sharma S, Zhang T, Michowski W, Rebecca VW, Xiao M, Ferretti R, Suski JM, Bronson RT, Paulo JA, Frederick D, Fassl A, Boland GM, Geng Y, Lees JA, Medema RH, Herlyn M, Gygi SP, Sicinski P.   +17 more
europepmc   +5 more sources

Cyclin-dependent kinase 5 mediates pleiotrophin-induced endothelial cell migration. [PDF]

Sci Rep, 2018
Pleiotrophin (PTN) stimulates endothelial cell migration through binding to receptor protein tyrosine phosphatase beta/zeta (RPTPβ/ζ) and ανβ3 integrin.
Lampropoulou E, Logoviti I, Koutsioumpa M, Hatziapostolou M, Polytarchou C, Skandalis SS, Hellman U, Fousteris M, Nikolaropoulos S, Choleva E, Lamprou M, Skoura A, Megalooikonomou V, Papadimitriou E.   +13 more
europepmc   +5 more sources

Ocular expression of cyclin‐dependent kinase 5 in patients with proliferative diabetic retinopathy [PDF]

Journal of Diabetes Investigation, 2022
Aims/Introduction Inhibition of peroxisome proliferator‐activated receptor gamma (PPARγ) phosphorylation mediated by cyclin‐dependent kinase 5 (Cdk5) is one of the main mechanisms of action of antidiabetic drugs.
Hiroki Sano, Kazuhiko Namekata, Masanori Niki, Kentaro Semba, Fumiko Murao, Takayuki Harada, Yoshinori Mitamura   +6 more
doaj   +2 more sources

The role of cyclin-dependent kinase 5 in neuropathic pain. [PDF]

Pain, 2020
The chronification of pain can be attributed to changes in membrane receptors and channels underlying neuronal plasticity and signal transduction largely within nociceptive neurons that initiate and maintain pathological pain states.
Gomez K, Vallecillo TGM, Moutal A, Perez-Miller S, Delgado-Lezama R, Felix R, Khanna R.   +6 more
europepmc   +2 more sources

Inhibition of Cyclin-Dependent Kinase 5: A Strategy to Improve Sorafenib Response in Hepatocellular Carcinoma Therapy. [PDF]

Hepatology, 2019
Therapeutic options for patients with advanced‐stage hepatocellular carcinoma (HCC) are very limited. The only approved first‐line treatment is the multi‐tyrosine kinase inhibitor sorafenib, which shows low response rates and severe side effects.
Ardelt MA, Fröhlich T, Martini E, Müller M, Kanitz V, Atzberger C, Cantonati P, Meßner M, Posselt L, Lehr T, Wojtyniak JG, Ulrich M, Arnold GJ, König L, Parazzoli D, Zahler S, Rothenfußer S, Mayr D, Gerbes A, Scita G, Vollmar AM, Pachmayr J.   +21 more
europepmc   +2 more sources

Cyclin-dependent kinase 5 (CDK5) inhibitors in Parkinson disease. [PDF]

J Cell Mol Med
AbstractCyclin‐dependent kinase 5 (Cdk5) is a protein expressed in postmitotic neurons in the central nervous system (CNS). Cdk5 is activated by p35 and p39 which are neuron regulatory subunits. Cdk5/p35 complex is activated by calpain protease to form Cdk5/p35 which has a neuroprotective effect by regulating the synaptic plasticity and memory ...
Alrouji M, Al-Kuraishy HM, Al-Gareeb AI, Alshammari MS, Alexiou A, Papadakis M, Bahaa MM, Batiha GE.   +7 more
europepmc   +3 more sources

Activation of Cyclin-Dependent Kinase 5 Mediates Orofacial Mechanical Hyperalgesia

Molecular Pain, 2013
Background Cyclin-dependent kinase 5 (Cdk5) is a unique member of the serine/threonine kinase family. This kinase plays an important role in neuronal development, and deregulation of its activity leads to neurodegenerative disorders.
Michaela Prochazkova, Anita Terse, Niranjana D Amin, Bradford Hall, Elias Utreras, Harish C Pant, Ashok B Kulkami   +6 more
doaj   +3 more sources

Phosphorylation of drebrin by cyclin-dependent kinase 5 and its role in neuronal migration. [PDF]

PLoS ONE, 2014
Cyclin-dependent kinase 5 (Cdk5)-p35 is a proline-directed Ser/Thr kinase which plays a key role in neuronal migration, neurite outgrowth, and spine formation during brain development.
Kazuya Tanabe, Hiroyuki Yamazaki, Yutaka Inaguma, Akiko Asada, Taeko Kimura, Junya Takahashi, Masato Taoka, Toshio Ohshima, Teiichi Furuichi, Toshiaki Isobe, Koh-ichi Nagata, Tomoaki Shirao, Shin-ichi Hisanaga   +12 more
doaj   +2 more sources

Regulation of NMDA receptors by cyclin-dependent kinase-5 [PDF]

Proceedings of the National Academy of Sciences, 2001
Members of the N -methyl- d -aspartate (NMDA) class of glutamate receptors (NMDARs) are critical for development, synaptic transmission, learning and memory; they are targets of pathological disorders in the central nervous system.
Bing‐sheng Li, Miao-Kun Sun, Lei Zhang, Satoru Takahashi, Wu Ma, L. Vinadé, A. Kulkarni, R. Brady, H. Pant   +8 more
semanticscholar   +3 more sources