Cyclin-dependent kinase 5 (CDK5) regulates the circadian clock [PDF]
eLife, 2019 Circadian oscillations emerge from transcriptional and post-translational feedback loops. An important step in generating rhythmicity is the translocation of clock components into the nucleus, which is regulated in many cases by kinases.
Andrea Brenna +9 more
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Ocular expression of cyclin‐dependent kinase 5 in patients with proliferative diabetic retinopathy [PDF]
Journal of Diabetes Investigation, 2022 Aims/Introduction Inhibition of peroxisome proliferator‐activated receptor gamma (PPARγ) phosphorylation mediated by cyclin‐dependent kinase 5 (Cdk5) is one of the main mechanisms of action of antidiabetic drugs.
Hiroki Sano +6 more
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Inactivation of Cyclin-Dependent Kinase 5 in Hair Cells Causes Hearing Loss in Mice [PDF]
Frontiers in Molecular Neuroscience, 2018 Cyclin-dependent kinase 5 (CDK5) is abundantly expressed in post-mitotic cells including neurons. It is involved in multiple cellular events, such as cytoskeletal dynamics, signaling cascades, gene expression, and cell survival, et al.
Xiaoyan Zhai +7 more
doaj +2 more sources
Cyclin-dependent kinase 5 acts as a promising biomarker in clear cell Renal Cell Carcinoma [PDF]
BMC Cancer, 2019 Background This research provides the first evidence of CDK5 in ccRCC prognosis and correlation with different p21 expression in overall survival (OS) analysis.
Liangsong Zhu +4 more
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Systemic Administration of a Brain Permeable Cdk5 Inhibitor Alters Neurobehavior
Frontiers in Pharmacology, 2022 Cyclin-dependent kinase 5 (Cdk5) is a crucial regulator of neuronal signal transduction. Cdk5 activity is implicated in various neuropsychiatric and neurodegenerative conditions such as stress, anxiety, depression, addiction, Alzheimer’s disease, and ...
Alan Umfress +11 more
doaj +1 more source
Regulation of Sox6 by cyclin dependent kinase 5 in brain. [PDF]
PLoS ONE, 2014 Cyclin dependent kinase 5 (Cdk5) is a proline-directed Ser/Thr kinase involved in various biological functions during normal brain development and neurodegeneration.
Parvathi Rudrabhatla +3 more
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Cyclin B1/Cdk1 phosphorylation of mitochondrial p53 induces anti-apoptotic response. [PDF]
, 2010 The pro-apoptotic function of p53 has been well defined in preventing genomic instability and cell transformation. However, the intriguing fact that p53 contributes to a pro-survival advantage of tumor cells under DNA damage conditions raises a critical ...
Duru, Nadire +5 more
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Inhibition of Cdk5 Ameliorates Skeletal Bone Loss in Glucocorticoid-Treated Mice
Biomedicines, 2022 Glucocorticoids (GCs) are widely used to treat inflammatory diseases. However, their long-term use leads to glucocorticoid-induced osteoporosis, increasing morbidity and mortality. Both anabolic and anti-resorptive drugs are used to counteract GC-induced
Benjamin Thilo Krüger +8 more
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PPM1A Controls Diabetic Gene Programming through Directly Dephosphorylating PPAR?? at Ser273 [PDF]
, 2020 Peroxisome proliferator-activated receptor gamma (PPAR gamma) is a master regulator of adipose tissue biology. In obesity, phosphorylation of PPAR gamma at Ser273 (pSer273) by cyclin-dependent kinase 5 (CDK5)/extracellular signal-regulated kinase (ERK ...
Choi, Jang Hyun +11 more
core +1 more source
Regulation of neuronal cav3.1 channels by cyclin-dependent kinase 5 (Cdk5). [PDF]
PLoS ONE, 2015 Low voltage-activated (LVA) T-type Ca2+ channels activate in response to subthreshold membrane depolarizations and therefore represent an important source of Ca2+ influx near the resting membrane potential.
Aida Calderón-Rivera +4 more
doaj +1 more source