Results 11 to 20 of about 259,012 (283)
Targeting the cyclin-dependent kinase 5 in metastatic melanoma. [PDF]
Proc Natl Acad Sci U S A, 2020 Significance Melanomas are notorious due to their propensity to form lethal metastases. Currently, no treatments are available to stop the metastatic spread. We observed that in malignant melanomas, a protein called the cyclin-dependent kinase 5 (CDK5) is essential for melanoma metastasis.
Sharma S +17 more
europepmc +4 more sources
Cyclin‐dependent kinase‐5 in neurodegeneration [PDF]
Journal of Neurochemistry, 2004 AbstractCyclin‐dependent kinase‐5 (CDK5) is predominantly active in the nervous system and it is well established that CDK5 is essential in neuronal development. In addition to its recognized role in development, there is increasing evidence that CDK5 may be involved in the pathogenesis of several neurodegenerative disorders.
Shirley B, Shelton, Gail V W, Johnson
openaire +3 more sources
Cyclin-dependent kinase 5 (CDK5) inhibitors in Parkinson disease. [PDF]
J Cell Mol MedAbstractCyclin‐dependent kinase 5 (Cdk5) is a protein expressed in postmitotic neurons in the central nervous system (CNS). Cdk5 is activated by p35 and p39 which are neuron regulatory subunits. Cdk5/p35 complex is activated by calpain protease to form Cdk5/p35 which has a neuroprotective effect by regulating the synaptic plasticity and memory ...
Alrouji M +7 more
europepmc +3 more sources
International Journal of Preventive Medicine, 2021 Background: The cell cycle is divided into four phases, G1, G2, S, and M phase. The mammalian cell cycle is controlled and governed by the kinase complexes including cyclin and the cyclin-dependent kinase (CDK), cyclin-CDK complexes.
Masumeh Sanaei +2 more
doaj +1 more source
Cyclin-dependent Kinase 5 Promotes Insulin Exocytosis [PDF]
Journal of Biological Chemistry, 2001 Cyclin-dependent kinase 5 (Cdk5) is widely expressed although kinase activity has been described preferentially in neuronal systems. Cdk5 has an impact on actin polymerization during neuronal migration and neurite outgrowth and deregulation of the kinase has been implicated in the promotion of neurodegeneration.
L, Lilja +5 more
openaire +2 more sources
Neurogenesis and gliogenesis modulation in cerebral ischemia by CDK5 RNAi-based therapy
Biomédica: revista del Instituto Nacional de Salud, 2018 Introduction: Cerebral ischemia is the third cause of death risk in Colombia and the first cause of physical disability worldwide. Different studies on the silencing of the cyclin-dependent kinase 5 (CDK5) have shown that reducing its activity is ...
Juan Ignacio Muñoz-Manco +2 more
doaj +1 more source
Biological functions of CDK5 and potential CDK5 targeted clinical treatments. [PDF]
, 2017 Cyclin dependent kinases are proline-directed serine/threonine protein kinases that are traditionally activated upon association with a regulatory subunit.
Casimiro, Mathew C. +2 more
core +2 more sources
CAPTURE of the Human U2 snRNA Genes Expands the Repertoire of Associated Factors
Biomolecules, 2022 In order to identify factors involved in transcription of human snRNA genes and 3′ end processing of the transcripts, we have carried out CRISPR affinity purification in situ of regulatory elements (CAPTURE), which is deadCas9-mediated pull-down, of the ...
Joana Guiro +6 more
doaj +1 more source
Frontiers in Pharmacology, 2023 Sevoflurane is widely used for maternal anesthesia during pregnancy. Sevoflurane exposure of rats at mid-gestation can cause abnormal development of the central nervous system in their offspring.
Yuxiao Wan +3 more
doaj +1 more source
Antioxidants, 2023 The DNA glycosylase NEIL2 plays a central role in maintaining genome integrity, in particular during oxidative stress, by recognizing oxidized base lesions and initiating repair of these via the base excision repair (BER) pathway.
Camilla Myrup Holst +6 more
doaj +1 more source