Results 111 to 120 of about 28,797 (249)

Selective In Vivo and In Vitro Effects of a Small Molecule Inhibitor of Cyclin-Dependent Kinase 4 [PDF]

, 2017
Background: Cyclin-dependent kinase 4 (Cdk4) represents a prime target for the treatment of cancer because most human cancers are characterized by overexpression of its activating partner cyclin D1, loss of the natural Cdk4-specific inhibitor p16, or ...
Chaudhuri, Bhabatosh, Fabbro, Doriano, Fretz, Heinz, Furet, Pascal, Muller, Lionel, O'Reilly, Terence, Soni, Rajeev, Stephan, Christine, Zumstein-Mecker, Sabine   +8 more
core  

Targeting cyclin-dependent kinase 1 (CDK1) but not CDK4/6 or CDK2 is selectively lethal to MYC-dependent human breast cancer cells [PDF]

, 2014
Background Although MYC is an attractive therapeutic target for breast cancer treatment, it has proven challenging to inhibit MYC directly, and clinically effective pharmaceutical agents targeting MYC are not yet available. An alternative approach is to
Kang, Jian, Musgrove, Elizabeth A., Sergio, C. Marcelo, Sutherland, Robert L.   +3 more
core   +2 more sources

Cyclin-dependent kinase inhibitors [PDF]

, 2009
Stanični ciklus je jedan od najvažnijih procesa koji se događa u stanicama. Omogućuje prenošenje identičnog genetičkog materijala iz generacije u generaciju i osigurava da isti ostane kompletno očuvan.
Jemin, Nikolina
core   +2 more sources

The role of cyclin D2 and p21/waf1 in human T-cell leukemia virus type 1 infected cells [PDF]

, 2004
Background The human T-cell leukemia virus type 1 (HTLV-1) Tax protein indirectly influences transcriptional activation, signal transduction, cell cycle control, and apoptosis. The function of Tax primarily relies on protein-protein interactions. We have
Pumfery Anne, Rufner Robyn, Baylor Shanese, Maddukuri Anil, Wu Kaili, Strouss Katharine, de la Fuente Cynthia, Deng Longwen, Kehn Kylene, Bottazzi Maria Elena, Kashanchi Fatah   +10 more
core   +1 more source

Prognostic biomarkers and their impact on treatment strategy selection for patients with advanced stages of oropharyngeal cancer

Medičnì Perspektivi
The study of prognostic biomarkers is crucial for personalising and enhancing the effectiveness of oropharyngeal cancer treatment, as they help identify patients with aggressive disease progression and determine the optimal patient management strategy ...
V.V. Rakhmanov, I.S. Shponka
doaj   +1 more source

Estudo genético do gene p16 pela técnica de PCR-SSCP e expressão de proteína p16 em melanomas de mucosa oral e melanomas cutâneos Genetic analysis of p16 gene by PCR-SSCP technique and protein p16 expression in oral mucosa and skin melanomas

Anais Brasileiros de Dermatologia, 2006
FUNDAMENTOS: A deleção e mutação do gene CDKN2a que codifica um inibidor específico da ciclina dependente de quinase 4, a proteína p16, têm sido implicadas na tumorigênese do melanoma cutâneo. Entretanto, pouco se conhece sobre essas alterações genéticas
Ricardo Hsieh, Fabrício Bitu Sousa, Aline Firmiano, Fabio Daumas Nunes, Marina Helena Cury Gallottini de Magalhães, Mírian Nacagami Sotto   +5 more
doaj   +1 more source

Mutational and methylation analysis of the cyclin‐dependent kinase 4 inhibitor (p16^INK4A) gene in chronic lymphocytic leukemia

European Journal of Haematology, 2006
Abstract:  Objectives: Chronic lymphocytic leukemia (CLL) comprises a heterogenous group of at least two types of disease entities characterized by distinctive clinical, immunophenotypical and genetic features. The molecular mechanisms underlying the pathogenesis and the histological transformation of CLL are not well known.
Tsirigotis, P, Pappa, V, Labropoulos, S, Papageorgiou, S, Kontsioti, F, Dervenoulas, J, Papageorgiou, E, Panani, A, Mantzios, G, Economopoulos, T, Raptis, S   +10 more
openaire   +3 more sources

Significance and limitations of routine p16/Ki-67 immunohistochemistry as a diagnostic tool for high-grade squamous intraepithelial lesions of the uterine cervix [PDF]

Obstetrics & Gynecology Science
Objective To evaluate the diagnostic utility and limitations of routine p16 and Ki-67 immunohistochemistry (IHC) in detecting high-grade squamous intraepithelial lesions (HSILs) in the uterine cervix.
Kazutaka Ozono, Fumi Kawakami, Yoshiki Mikami   +2 more
doaj   +1 more source

Evaluation of p16 and Ki67 expression in cervical neoplasm and its association with human papillomavirus infection: An observational study

Journal of Indira Gandhi Institute of Medical Sciences
Introduction: Cervical cancer is the fourth-most common cancer among females associated with strong viral etiology. Nearly 99.7% of cases are associated with persistent high-risk human papillomavirus infection (hr-HPV).
Anila Sinha, Kalpana Chandra, Richa Sharma, Archana Sinha, Nidhi Prasad, Simran Suman, Ayushi Singh   +6 more
doaj   +1 more source

Phase 1 Study Evaluating the Association of the Cyclin-Dependent Kinase 4/6 Inhibitor Ribociclib and Cetuximab in Recurrent/Metastatic p16-Negative Squamous Cell Carcinoma of the Head and Neck [PDF]

, 2019
Emmanuel Seront, Sandra Schmitz, M. Papier, Aline van Maanen, Stéphanie Henry, Christophe Lonchay, Sylvie Rottey, Gabrielle van Caloen, Jean‐Pascal Machiels   +8 more
openalex   +1 more source