Results 111 to 120 of about 29,685 (221)

Cell-cycle protein expression in a population-based study of ovarian and endometrial cancers

Frontiers in Oncology, 2015
Aberrant expression of cyclin-dependent kinase (CDK) inhibitors is implicated in the carcinogenesis of many cancers, including ovarian and endometrial cancers.
Ashley S. Felix, Mark E. Sherman, Stephen M. Hewitt, Munira eGunja, Hannah P. Yang, Renata eCora, Vicky eBoudreau, Kris eYlaya, Jolanta eLissowska, Louise A. Brinton, Nicolas eWentzensen   +10 more
doaj   +1 more source

Cell Cycle Control by Xenopus p28^(Kix1) a Developmentally Regulated Inhibitor of Cyclin-dependent Kinases [PDF]

, 1996
We have isolated Xenopus p28^(Kix1), a member of the p21^(CIP1)/p27^(KIP1)/p57^(KIP2) family of cyclin-dependent kinase (Cdk) inhibitors. Members of this family negatively regulate cell cycle progression in mammalian cells by inhibiting the activities of
Dunphy, William G., Shou, Wenying
core  

Selective In Vivo and In Vitro Effects of a Small Molecule Inhibitor of Cyclin-Dependent Kinase 4 [PDF]

, 2017
Background: Cyclin-dependent kinase 4 (Cdk4) represents a prime target for the treatment of cancer because most human cancers are characterized by overexpression of its activating partner cyclin D1, loss of the natural Cdk4-specific inhibitor p16, or ...
Chaudhuri, Bhabatosh, Fabbro, Doriano, Fretz, Heinz, Furet, Pascal, Muller, Lionel, O'Reilly, Terence, Soni, Rajeev, Stephan, Christine, Zumstein-Mecker, Sabine   +8 more
core  

Aberrant p16 methylation as an early diagnostic marker in blood of hepatocellular carcinoma patients

Egyptian Journal of Medical Human Genetics, 2019
Background Alpha-fetoprotein (AFP) is currently used for serologic screening in hepatocellular carcinoma (HCC) but with low sensitivity ranging 41–65% with a high rate of false-negative and false-positive results.
Arig Aly Seif, Heba Hassan Aly, Doaa Mostafa Elzoghby, Ashraf Mohammed Elbreedy, Mohamed Lotfy   +4 more
doaj   +1 more source

RNA splicing variants of the novel long non-coding RNA, CyKILR, possess divergent biological functions in non-small cell lung cancer

Molecular Therapy: Nucleic Acids
The CDKN2A gene, responsible for encoding the tumor suppressors p16(INK4A) and p14(ARF), is frequently inactivated in non-small cell lung cancer (NSCLC). Herein, an uncharacterized long non-coding RNA (lncRNA) (ENSG00000267053) on chromosome 19p13.12 was
Xiujie Xie, H. Patrick Macknight, Amy L. Lu, Charles E. Chalfant   +3 more
doaj   +1 more source

Sodium valproate affects the expression of p16^INK4a and p21^WAFI/Cip1 cyclin‑dependent kinase inhibitors in HeLa cells

Oncology Letters
p16INK4a and p21WAF1/Cip1 are cyclin-dependent kinase inhibitors involved in cell cycle control, which can function as oncogenes or tumor suppressors, depending on the context of various extracellular and intracellular signals, and cell type. In human papillomavirus-induced cervical cancer, p16 INK4a shows oncogenic activity and functions as a ...
Rocha, Marina Amorim, Cardoso, Adauto Lima, Martins, Cesar, Mello, Maria Luiza S.   +3 more
openaire   +2 more sources

Analysis of p16 gene mutations and deletions in childhood acute lymphoblastic leukemias

São Paulo Medical Journal
CONTEXT: The p16 tumor suppressor gene encodes a cyclin-dependent kinase 4 inhibitor that blocks cell division during the G1 phase of the cell cycle. Alterations in this gene have been reported for various neoplasia types, including acute lymphoblastic ...
José Alexandre Rodrigues Lemos, Ricardo Defavery, Carlos Alberto Scrideli, Luiz Gonzaga Tone   +3 more
doaj   +1 more source

Nucleic acid technology and infectious diseases [PDF]

, 1997
The past decade has witnessed an explosion in the knowledge of microbial genetics, pathogenesis, and antimicrobial resistance as a result of advances in molecular technology.
Luk, WK, Wong, SSY, Woo, PCY, Yuen, KY
core  

Comparison of senescence progression in mesenchymal cells from human umbilical cord walls measured by immunofluorescence and flow cytometry of p16 and p21

Einstein (São Paulo)
Objective To follow the expansion of mesenchymal stem cells from umbilical cords by two classic senescence markers, p16 (INK4A) and p21 (CDKN1A), using practical, fast, and less expensive methods than the gold standard Western blotting technique, to ...
Aline da Silva, Carla de Azevedo Piccinato, Luiz Roberto Sardinha, Thiago Pinheiro Arrais Aloia, Anna Carla Goldberg   +4 more
doaj   +2 more sources

Oxamate alleviates silicotic fibrosis in mice by inhibiting senescence of alveolar type II epithelial cells

环境与职业医学
BackgroundThe senescence of alveolar type II epithelial cells is an important driving factor for the progression of silicotic fibrosis, and the regulatory effects of oxamate on the senescence of alveolar type II epithelial cells is still unclear ...
Wenjing LIU, Na MAO, Yaqian LI, Xuemin GAO, Zhongqiu WEI, Ying ZHU, Hong XU, Fuyu JIN   +7 more
doaj   +1 more source