Results 101 to 110 of about 28,898 (227)
A Survey on Association of P16 Protein and Uterine Cervical Dysplasia
مجله دانشکده پزشکی اصفهان, 2011 Background: Cervical (uterine) carcinoma is the second most frequent type of women cancer. Success in early diagnosis of this disease is due to the use of pap-smear test. However, this test has both false-positive and false-negative results.
Babak Izadi +2 more
doaj
Cell-Cycle Protein Expression in a Population-Based Study of Ovarian and Endometrial Cancers [PDF]
, 2015 Aberrant expression of cyclin-dependent kinase (CDK) inhibitors is implicated in the carcinogenesis of many cancers, including ovarian and endometrial cancers.
Ashley S. Felix +10 more
core +2 more sources
Aging Cell, Volume 25, Issue 5, May 2026.Organ‐specific aging clocks integrating genomics, epigenomics, transcriptomics, proteomics, and metabolomics offer a more accurate assessment of biological aging than single‐omics approaches. This review proposes a multi‐omics framework emphasizing tissue data, longitudinal study designs, and clinically meaningful training outcomes to advance the ...
Maria Vasileiou +3 more
wiley +1 more source
Regulation of the retinoblastoma proteins by the human herpesviruses [PDF]
, 2009 Viruses are obligate intracellular parasites that alter the environment of infected cells in order to replicate more efficiently. One way viruses achieve this is by modulating cell cycle progression.
Kalejta Robert F, Hume Adam J
core +2 more sources
Aging Cell, Volume 25, Issue 5, May 2026.Cellular senescence and mitochondrial dysfunction disrupt adipose tissue homeostasis during aging, but mechanisms remain unclear. HDAC9 expression increases with age in mouse adipose tissue and Hdac9 knockout mice showed reduced fat mass, senescence markers, and enhanced mitochondrial gene expression, respiration, and thiosulfate sulfurtransferase (Tst)
Brandee Goo +15 more
wiley +1 more source
The role of p21Waf 1/CIP1 as a Cip/Kip type cell-cycle regulator in oral squamous cell carcinoma: review [PDF]
, 2013 Oral Squamous Cell Carcinoma (OSCC) is biologically characterized by the accumulation of multiple genetic and molecular alterations that end up clinically characterized as a malignant neoplasm through a phenomenon known as multistep.
Barros Angueira, Francisco +5 more
core +1 more source
T Cell Immunosenescence in Inflammatory Skin Diseases: Pathogenesis and Therapeutic Targets
Aging Cell, Volume 25, Issue 5, May 2026.Immunosenescent T cells promote inflammatory skin diseases such as psoriasis, atopic dermatitis, rosacea, and seborrheic dermatitis via hyperactive signaling networks and SASP secretion. Consequently, intercepting downstream SASP, inhibiting internal pathways, or utilizing senolytics represents promising therapeutic interventions.
Conghui Liu +3 more
wiley +1 more source
Orthopaedic Surgery, Volume 18, Issue 5, Page 897-914, May 2026.As the key mechanotransducer in IVDD, Piezo1 orchestrates region‐specific degeneration across NP (senescence/ECM dysregulation), AF (apoptosis), and CEP (inflammation). This review integrates mechanistic pathways and assesses multimodal therapeutic targeting (pharmacologic/genetic/nutritional) to restore disc homeostasis.
Guangye Li +5 more
wiley +1 more source
Getting old through the blood. Circulating molecules in aging and senescence of cardiovascular regenerative cells [PDF]
, 2017 Global aging is a hallmark of our century. The natural multifactorial process resulting in aging involves structural and functional changes, affecting molecules, cells, and tissues.
Angelini, Francesco +5 more
core +2 more sources