Results 81 to 90 of about 3,597,789 (164)

CDKN2a (cyclin dependent kinase 2a / p16) [PDF]

, 2008
Review on CDKN2a (cyclin dependent kinase 2a / p16), with data on DNA, on the protein encoded, and where the gene is ...
Lemoine, A, Debuire, B, Saffroy, R
core   +1 more source

Hydrogen sulfide attenuates oxidative stress-induced cellular senescence via the Sirt3/SOD2 signaling pathway in chronic obstructive pulmonary disease

Chinese Medical Journal
. Background:. Senescence significantly participates in shaping the pathobiological process underlying chronic obstructive pulmonary disease (COPD). Currently, the mechanisms underlying the anti-aging effects of hydrogen sulfide (H2S) in COPD are not ...
Sha Liao, Dian Chen, Huanyu Long, Simin Jiang, Jing Fan, Shurun Li, Yongfen Qi, Lixiang Xue, Yanling Ding, Yahong Chen, Xiangxiang Pan   +10 more
doaj   +1 more source

Born early, age fast: Consequences of premature birth on chronic disease and accelerated ageing

The Journal of Physiology, EarlyView.
Abstract figure legend ELGANs are exposed to several postnatal pro‐oxidant stressors, including ambient and supplemental oxygen, mechanical ventilation, infections, hyperalimentation, excessive glucocorticoids and intermittent hypoxia. Since endogenous antioxidant defences are underdeveloped, this imbalance promotes oxidative stress and inflammation ...
Estelle B. Gauda, Julijana Ivanovska, Dwayne Mascarenhas, Jeffrey Antwi, Atefeh Mohammadi, Bonny Jasani   +5 more
wiley   +1 more source

A Survey on Association of P16 Protein and Uterine Cervical Dysplasia

مجله دانشکده پزشکی اصفهان, 2011
Background: Cervical (uterine) carcinoma is the second most frequent type of women cancer. Success in early diagnosis of this disease is due to the use of pap-smear test. However, this test has both false-positive and false-negative results.
Babak Izadi, Sedigheh Khazaei, Sayed Ghasem Mirbahari   +2 more
doaj  

Comprehensive genomic profiling of mucosal melanoma reveals novel fusion transcripts and dysregulation of cell‐cycle, MAPK, and PI3K pathways

The Journal of Pathology, Volume 270, Issue 3, Page 380-395, November 2026.
Abstract Mucosal melanomas (MMs) are rare, aggressive cancers with poor outcomes and limited response to standard therapies. A significant knowledge gap exists regarding their genomic landscape and corresponding druggable targets. This study explores this issue through a multi‐omic analysis, including whole exome‐, RNA‐, and targeted sequencing, of ...
Matilde Monti, Martina Brigida Romanello, Luca Agnelli, Matteo Orlandi, Luca Bertoli, Sara Picinoli, Irene Pezzali, Giulio Eugenio Mandelli, Daniela Medicina, Giovanni Ribaudo, Adele Busico, Elena Conca, Vilma Pellegrini, Piera Balzarini, Daniele Gallucci, Anna Di Matteo, Davide Lombardi, Claudia Ghigna, Giancarlo Pruneri, Alessandra Gianoncelli, Marzia Rossato, William Vermi   +21 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, Volume 20, Issue 10, Page 2410-2423, October 2026.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

CDK4/MERCs/PINK1 Axis Drives PFOA/HFPO‐TA‐Induced Cardiac Senescence via Mitophagy Defect and cGAS‐STING Activation: In Vitro Amelioration by Cycloastragenol

Advanced Science, Volume 13, Issue 56, 9 October 2026.
The present study demonstrated that PFOA and HFPO‐TA exposure suppressed CDK4, disrupted MERCs and impaired PINK1/Parkin‐mediated mitophagy, thereby accelerating cardiac senescence, whereas CAG effectively reversed these pathological changes in vitro. Our findings identify CDK4 as a critical regulator bridging mitophagy defects and cardiac senescence ...
Nuo‐Wa Li, Jun‐Ze Jiang, Ying‐Ying Liu, Tian‐Tian Zhang, Kanwar Kumar Malhi, Xin Yao, Jin‐Long Li   +6 more
wiley   +1 more source

Effect of p21Waf1 and p27Kip1 on centrosome replication and proliferation of breast cancer cell [PDF]

, 2010
Aberrant centrosome numbers are detected in virtually all cancers，increasing the risk for cell division errors and chromosomal instability.
Yin-Lin Ge, Dan-Dan Jiang, Fu-Nian Li, Ming-Zhi Cao, Xiang-Ping Liu, Xin-Gang Wang   +5 more
core  

Xenopus NM23-X4 regulates retinal gliogenesis through interaction with p27Xic1 [PDF]

, 2009
Background. In Xenopus retinogenesis, p27Xic1, a Xenopus cyclin dependent kinase inhibitor, functions as a cell fate determinant in both gliogenesis and neurogenesis in a context dependent manner.
Toshiaki Mochizuki, Zollo Massimo, Ohnuma, S-I, Bilitou, A, Bilitou Aikaterini, Ohnuma Shin-ichi, Waters Caroline T, Massimo Zollo, Shin-ichi Ohnuma, Mochizuki, Toshiaki, Aikaterini Bilitou, Kamran Hussain, Caroline T Waters, Hussain Kamran, Zollo, M, Waters, CT, Mochizuki Toshiaki, Hussain, K, Mochizuki, T   +18 more
core   +1 more source

Protective Effect of Multifloral Honey on Stem Cell Aging in a Dynamic Cell Culture Model

Antioxidants
Natural compounds, as honey-derived flavonoids and phenolic compounds, are increasingly investigated for their potential to mitigate skin aging and prevent oxidative stress-induced cellular damages.
Fikriye Fulya Kavak, Sara Cruciani, Giuseppe Garroni, Diletta Serra, Rosanna Satta, Ibrahim Pirim, Melek Pehlivan, Margherita Maioli   +7 more
doaj   +1 more source