Results 71 to 80 of about 3,597,789 (164)

Loss of chromosome arm 9p DNA and analysis of the p16 and p15 cyclin-dependent kinase inhibitor genes in human parathyroid adenomas. [PDF]

The Journal of Clinical Endocrinology & Metabolism, 1996
Rearrangement and overexpression of the PRAD1/cyclin D1 oncogene, a cell cycle regulator, have been implicated in the pathogenesis of a subset of parathyroid adenomas. Recently, two cell cycle regulators that inhibit the cyclin D1-associated kinases cdk4 and cdk6 have been identified: p16 and p15, the products of the INK4A (also known as CDKN2, MTS1 ...
H, Tahara, A P, Smith, R D, Gaz, A, Arnold   +3 more
openaire   +2 more sources

Cellular Senescence: A Pathogenic Driver for Pulmonary Fibrosis

Frontiers in Bioscience-Landmark
Pulmonary fibrosis is a life-threatening progressive lung disease characterized by increased fibrogenesis and decreased lung function. Pulmonary fibrosis has a poor prognosis and a low patient survival rate, with no effective treatments currently ...
Sihan Wang, Rongrong Wang, Qiyuan He, Yicheng Ma, Yanyuan Fang, Jin Yang, Hui Zhao, Lin Fu, Danlei Chen   +8 more
doaj   +1 more source

From senescence and inflammaging to systemic comorbidities: Drivers of aging‐associated periodontitis

Periodontology 2000, EarlyView.
Abstract Background Aging is accompanied by a chronic low‐grade inflammatory process, known as inflammaging, as well as immunosenescence, an age‐related decline and dysregulation of immune function, and cellular senescence, a process in which cells enter a state of irreversible growth arrest while actively releasing pro‐inflammatory factors.
James Cheng, Chew Tin Zar Aung, Samuel F. Suslavich, Sinem Esra Sahingur, Yvonne L. Hernandez‐Kapila   +4 more
wiley   +1 more source

Combined inhibition of BETs and HDACs as a potential epigenetics-based therapy for malignant rhabdoid tumor

Cell Death and Disease
Malignant rhabdoid tumors (MRT) are highly aggressive pediatric malignancies driven by SMARCB1 loss and consequent epigenetic dysregulation, with dismal survival rates underscoring the need for novel therapies.
Lingyan Zhu, Yuanyuan Li, Yaxian Wen, Jinxuan Wen, Junzhu Zhang, Lingzhao Min, Changsheng Li, Qi Peng, Lisha Wang, Anqi Li, Zebing Liu, Xiaoqiang Wang   +11 more
doaj   +1 more source

Establishment of Two Data Mining Models of Lung Cancer Screening Based on Three Gene Promoter Methylations Combined with Telomere Damage

The International Journal of Biological Markers, 2017
Objective To identify the significance of a support vector machine (SVM) model and a decision tree (DT) model for the diagnosis of lung cancer combined with the detection of fragile histidine triad (FHIT), RAS association domain family 1 (RASSF1A) and ...
Wei Wang, Xiaolei Feng, Xiaoran Duan, Shanjuan Tan, Sihua Wang, Tuanwei Wang, Feifei Feng, Yiming Wu, Yongjun Wu   +8 more
doaj   +1 more source

Understanding exosomes in facial esthetics and skin aging

Periodontology 2000, EarlyView.
Abstract Background Skin aging is a multifactorial process mediated by intrinsic (genetic and metabolic) and extrinsic (environmental) factors leading to functional and structural deterioration, including wrinkles, loss of collagen and elastin, as well as various pigmentation disorders.
Richard J. Miron, Catherine Davies, Anton Sculean, Paras Ahmad   +3 more
wiley   +1 more source

Normal levels of p27Xic1 are necessary for somite segmentation and determining pronephric organ size [PDF]

, 2009
The Xenopus laevis cyclin dependent kinase inhibitor p27Xic1 has been shown to be involved in exit from the cell cycle and differentiation of cells into a quiescent state in the nervous system, muscle tissue, heart and retina.
Collins, R.J., Collins, Robert J., Philpott, A, Philpott, Anna, Naylor, RW; id_orcid, Jones, Elizabeth A., Jones, E. A., Naylor, Richard William   +7 more
core   +1 more source

Notoginsenoside R2 attenuates hepatic fibrosis via STAT3-dependent hepatic stellate cells senescence induction and inflammatory microenvironment suppression

Journal of Ginseng Research
Background: Hepatic fibrosis (HF) continues to be a significant global health concern, substantially contributing to morbidity and mortality due to the absence of effective therapeutic options.
Kaili Deng, Min Li, Yuanyuan Li, Liangliang Xiang, Yuhua Wang, Hechen Shi, Jiayi Cheng, Sha Huang, Zhiping Lv   +8 more
doaj   +1 more source

Senolytics and exercise: Dual modalities for rejuvenating muscle

The Journal of Physiology, EarlyView.
Abstract figure legend The role of senolytics on the heart and skeletal muscle. Senescent cell burden increases with ageing, disuse and disease. The senolytics dasatinib+quercetin (D+Q), navitoclax and fisetin, as well as exercise, eliminate senescent cells, reducing senescent cell burden and their senescence‐associated secretory phenotype (SASP ...
Zeynep Elif Yesilyurt‐Dirican, Ce Qi, Uchenna Okpechi, Maya Strand Ford, Georgina M. Ellison‐Hughes   +4 more
wiley   +1 more source

Cyclin kinase inhibitor p21: a mediator of immune tolerance: direct and indirect evidence [PDF]

, 2009
*Background:* Uncontrolled proliferation of T-cells is considered a barrier to the induction of transplantation tolerance by T regulatory cells. Therefore, cyclin kinase inhibitor p21, one of the most potent inhibitors of cell proliferation, may exert an
Ashwani Khanna
core