Results 91 to 100 of about 16,580 (182)

Comparison of senescence progression in mesenchymal cells from human umbilical cord walls measured by immunofluorescence and flow cytometry of p16 and p21

Einstein (São Paulo)
Objective To follow the expansion of mesenchymal stem cells from umbilical cords by two classic senescence markers, p16 (INK4A) and p21 (CDKN1A), using practical, fast, and less expensive methods than the gold standard Western blotting technique, to ...
Aline da Silva, Carla de Azevedo Piccinato, Luiz Roberto Sardinha, Thiago Pinheiro Arrais Aloia, Anna Carla Goldberg   +4 more
doaj   +2 more sources

Sodium valproate affects the expression of p16^INK4a and p21^WAFI/Cip1 cyclin‑dependent kinase inhibitors in HeLa cells

Oncology Letters
p16INK4a and p21WAF1/Cip1 are cyclin-dependent kinase inhibitors involved in cell cycle control, which can function as oncogenes or tumor suppressors, depending on the context of various extracellular and intracellular signals, and cell type. In human papillomavirus-induced cervical cancer, p16 INK4a shows oncogenic activity and functions as a ...
Rocha, Marina Amorim, Cardoso, Adauto Lima, Martins, Cesar, Mello, Maria Luiza S.   +3 more
openaire   +2 more sources

CDK2 inhibition enhances CDK4/6 inhibitor antitumor activity in comprehensive breast cancer PDX model screen

npj Breast Cancer
Aberrant cyclin-dependent kinase 2 (CDK2) activity is implicated as a resistance mechanism to CDK4/6 inhibitors (CDK4/6i) in hormone receptor–positive (HR+)/human epidermal growth factor receptor 2-negative (HER2−) breast cancer.
Nealia C. House, Maxine M. Chen, Sima Khazaei, Victoria Brown, Philip Ramsden, David H. Peng, Sydney Moore, Liang Yuan, Rentian Wu, Fangyang Wang, Linjie Luo, Ningping Feng, Christopher A. Bristow, Timothy A. Yap, Khandan Keyomarsi, Joseph R. Marszalek, Scott Ribich, Mikael L. Rinne, Lakshmi B. Muthuswamy, Kerrie L. Faia   +19 more
doaj   +1 more source

Oxamate alleviates silicotic fibrosis in mice by inhibiting senescence of alveolar type II epithelial cells

环境与职业医学
BackgroundThe senescence of alveolar type II epithelial cells is an important driving factor for the progression of silicotic fibrosis, and the regulatory effects of oxamate on the senescence of alveolar type II epithelial cells is still unclear ...
Wenjing LIU, Na MAO, Yaqian LI, Xuemin GAO, Zhongqiu WEI, Ying ZHU, Hong XU, Fuyu JIN   +7 more
doaj   +1 more source

Searching for Selective Cyclin-Dependent Kinase Inhibitors to Target the Retinoblastoma/p16 Cancer Gene Pathway [PDF]

JNCI Journal of the National Cancer Institute, 2001
A. Kubo, F. J. Kaye
openaire   +1 more source

CDK4/6-targeted therapy for gastrointestinal cancers: from resistance mechanisms to immuno-combination strategies guided by biomarkers. [PDF]

Front Immunol
Cui J, Zhang Y, Wu Y, Zhang G, Lan J, Wang Y.   +5 more
europepmc   +1 more source

Precision targeting of <i>CCNE1</i>-amplified tumors-lessons from BLU-222 and beyond. [PDF]

Transl Cancer Res
Rantanen F, Ungureanu D.
europepmc   +1 more source

Efficacy and Mechanisms of CDK4/6 Inhibitors in Breast Cancer: Advancing Targeted Therapeutic Strategies. [PDF]

Oncol Res
Patwekar M, Patwekar F, Kari ZA, Zain MRAM, Mohammed A, Sharma R.   +5 more
europepmc   +1 more source

PRKN Ser131 phosphorylation promotes cigarette smoke-induced mitophagy impairment and epithelial cell senescence via MKK3/p38 MAPK activation: An in vitro and in vivo study. [PDF]

Tob Induc Dis
Hu Y, Liu J, Zhang M, Qu J, Hao W, Zhu X, Wu D, Jiang S, Qu Y.   +8 more
europepmc   +1 more source

p16 expression confers sensitivity to CDK2 inhibitors in cyclin E1-driven ovarian cancers. [PDF]

Sci Signal
Sine CC, Watts LP, Fernandez B, Marikar N, Wang J, Knudsen ES, Witkiewicz AK, Spencer SL.   +7 more
europepmc   +1 more source