Results 91 to 100 of about 3,597,789 (164)

Mapping Mutations and Signaling Network Interactions to Guide Precision Therapy in Gallbladder Cancer

Cancer Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background Gallbladder cancer (GBC) is a biologically complex malignancy arising from the epithelial lining of the gallbladder, with adenocarcinoma constituting the major histological subtype. Early detection is challenging because of vague clinical manifestations and the organ's deep‐seated anatomical location, resulting in diagnosis at ...
Nisha Manav, Akanksha Kashyap, Lakshay Malhotra, Chethan Rajegowda, Chandra Prakash Prasad   +4 more
wiley   +1 more source

Funktionelle Charakterisierung von Mitgliedern des MicroRNA-17-92-Clusters im Blutgefäßsystem [PDF]

, 2011
Almost two decades ago, microRNAs were discovered as novel posttranscriptional regulators of gene expression. Since then, research efforts have uncovered their involvement in the control of various cellular processes including migration, proliferation ...
Döbele, Carmen
core  

CDK-dependent nuclear localization of B-Cyclin Clb1 promotes FEAR activation during meiosis I in budding yeast [PDF]

, 2013
Cyclin-dependent kinases (CDK) are master regulators of the cell cycle in eukaryotes. CDK activity is regulated by the presence, post-translational modification and spatial localization of its regulatory subunit cyclin.
Sarkar, S. (Sourav), Sourav Sarkar, Novák, Béla, Tibbles, Katherine L., Prakash Arumugam, Arumugam P., Bela Novak (5648875), Sarkar S., Arumugam Prakash, Arumugam, Prakash, Sourav Sarkar (430861), Katherine Louise Tibbles (478963), Katherine Louise Tibbles, Bela Novak, Sarkar Sourav, Novak Bela, Tibbles Katherine Louise, Prakash Arumugam (303310), Tibbles K.L., Novak B.   +19 more
core   +2 more sources

Protective Effects of Nongxiang‐Type Tieguanyin on the Liver of D‐Galactose‐Induced Aging C57BL/6 Mice via the NF‐κB Signaling Pathway

Food Science &Nutrition, Volume 14, Issue 10, October 2026.
Mechanistic diagram of the hepatoprotective effect of Tgy‐N on D‐gal‐induced senescent C57BL/6 mice (“→” indicates activation, and “⊣” indicates inhibition). ABSTRACT This research aimed to investigate the hepatoprotective and anti‐senescence effects of Nongxiang‐type Tieguanyin (Tgy‐N) on D‐galactose (D‐gal)‐induced aging C57BL/6 mice and to elucidate
Weihong Chen, Mingmei Li, Lingxiao Ye, Dongqin Huang, Jianjia Xiao, Yuchao Sang, Zizhen Wang, Jiehong Yang, Chengyong He, Jiabin Chen, Zhenghong Zuo, Xintan Chen   +11 more
wiley   +1 more source

The prognostic significance of immunohistochemical expressions of proliferating cell nuclear antigen, P16 and Ki-67 in breast cancer

Frontiers in Oncology
AimThis study investigates the link between proliferation markers (PCNA, p16, Ki-67) and histopathological factors, exploring their prognostic value in breast cancer patients.Materials and methodsWe analyzed female breast cancer patients who underwent ...
Ali Duran, Hüseyin Pulat, Özlem Gübür, Eren Altun, Burak Yavuz, Ugur Topal, Alev Çetin Duran   +6 more
doaj   +1 more source

The Sleeping Giant: Metabolism and Autophagy in the Generation and Survival of Dormant Polyploid Giant Cancer Cells

MedComm, Volume 7, Issue 10, October 2026.
Polyploid giant cancer cells (PGCCs) arise in response to stress and play a critical role in therapy resistance and tumor dormancy. These cells can evade conventional treatments and later contribute to cancer relapse by generating progeny through nonmitotic, amitotic mechanisms.
Silvia Guil‐Luna, María Teresa Sánchez‐Montero, Alejandra Díaz‐Chacón, Antonio Rodríguez‐Ariza   +3 more
wiley   +1 more source

Combining the receptor tyrosine kinase inhibitor AEE788 and the mammalian target of rapamycin (mTOR) inhibitor RAD001 strongly inhibits adhesion and growth of renal cell carcinoma cells [PDF]

, 2009
Background Treatment options for metastatic renal cell carcinoma (RCC) are limited due to resistance to chemo- and radiotherapy. The development of small-molecule multikinase inhibitors have now opened novel treatment options.
Natsheh, Iyad Y. M., Eva Juengel, Mickuckyte, Ausra, Hudak, Lukasz, Jones, Jon, Roman A Blaheta, Lukasz Hudak, Jüngel, Eva, Dietger Jonas, Blaheta, Roman A., Johanna Engler, Iyad Natsheh, Ausra Mickuckyte, Jonas, Dietger, Jon Jones, Engler, Johanna   +15 more
core   +2 more sources

Alveolar Macrophages: Development, Respiratory Homeostasis, Signal Pathways, Diseases, and Therapeutic Opportunities

MedComm, Volume 7, Issue 10, October 2026.
Alveolar macrophages: development, respiratory homeostasis, signal pathways, diseases, and therapeutic opportunities: During embryonic development, fetal progenitors migrate to the developing lungs via a CX3CR1‐dependent mechanism to establish the TrAM pool.
Sihan Yang, Ruomeng Li, Chuanjiang Yu, Jing Li, Xikun Zhou   +4 more
wiley   +1 more source

The senomorphic impact of astaxanthin on irradiated rat spleen: STING, TLR4 and mTOR contributed pathway

International Journal of Immunopathology and Pharmacology
Objectives: Exposure of spleen tissues to ionizing radiation during radiotherapy can induce cellular stress and immune-dysfunction leading to cellular senescence.
Maha M Aziz, Marwa M El-Sheikh, Marwa A Mohamed, Sahar S Abdelrahman, Mai H Mekkawy   +4 more
doaj   +1 more source

Phytochemicals as Multitarget Therapeutics in Pancreatic Cancer: Mechanisms, Clinical Evidence, and Translational Challenges

Phytotherapy Research, Volume 40, Issue 10, Page 5973-5987, October 2026.
Pancreatic cancer, particularly pancreatic ductal adenocarcinoma, is aggressive and often diagnosed late, making treatment challenging. This review highlights the potential of phytochemicals, such as curcumin and quercetin, as multitarget agents that influence key carcinogenic pathways. These compounds exhibit anticancer effects by inhibiting processes
Md. Rezaul Islam, Abdur Rauf, F. M. Shourav, Hanan A. Ogaly, Abdullah S. M. Aljohani, Waleed Al Abdulmonem, Kamala Badalova, Marcello Iriti   +7 more
wiley   +1 more source