Results 111 to 120 of about 28,898 (227)

Cyclin D1-mediated microRNA expression signature predicts breast cancer outcome [PDF]

, 2018
Background: Genetic classification of breast cancer based on the coding mRNA suggests the evolution of distinct subtypes. Whether the non-coding genome is altered concordantly with the coding genome and the mechanism by which the cell cycle directly ...
Addya, Sankar, Casimiro, Mathew C., Deng, Shengqiong, DiSante, Gabriele, Dong, Lin, Ertel, Adam, Gormley, Michael, Ju, Xiaoming, Li, Qinchuan, Pestell, Richard G., Pestell, Timothy G., Qiao, Jing, Tozeren, Ayden, Wang, Guangxue, Wang, Min, Yu, Zuoren, Zhao, Qian   +16 more
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The senomorphic impact of astaxanthin on irradiated rat spleen: STING, TLR4 and mTOR contributed pathway

International Journal of Immunopathology and Pharmacology
Objectives: Exposure of spleen tissues to ionizing radiation during radiotherapy can induce cellular stress and immune-dysfunction leading to cellular senescence.
Maha M Aziz, Marwa M El-Sheikh, Marwa A Mohamed, Sahar S Abdelrahman, Mai H Mekkawy   +4 more
doaj   +1 more source

Combined Treatment with MEK and mTOR Inhibitors is Effective in In Vitro and In Vivo Models of Hepatocellular Carcinoma. [PDF]

, 2019
Background: Hepatocellular carcinoma (HCC) is the most common primary liver cancer histotype, characterized by high biological aggressiveness and scarce treatment options.
Calvisi, Diego F, Che, Li, Chen, Xin, Evert, Matthias, Hu, Junjie, Liu, Xianqiong, Lu, Xinjun, Song, Xinhua, Su, Tao, Utpatel, Kirsten, Wang, Jingxiao, Wang, Pan, Xu, Meng, Zhang, Jie, Zhang, Yi   +14 more
core   +1 more source

Role of the CDKN1A/p21, CDKN1C/p57, and CDKN2A/p16 Genes in the Risk of Atherosclerosis and Myocardial Infarction [PDF]

, 2009
Atherosclerosis is characterized by excessive proliferation of neointimal leukocytes and vascular smooth muscle cells (VSMCs). In mice, the manipulation of cell cycle inhibitors such as CDKN1B (p27) and CDKN1A (p21) modifies the risk of developing ...
Andrés, Vicente, Coto, Eliecer, González, Pelayo, Lozano, Iñigo, Martín, María, Morís, César, Reguero, J.R. (Julián), Rodríguez, Isabel, Álvarez, Victoria   +8 more
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Mutational and methylation analysis of the cyclin‐dependent kinase 4 inhibitor (p16^INK4A) gene in chronic lymphocytic leukemia

European Journal of Haematology, 2006
Abstract:  Objectives: Chronic lymphocytic leukemia (CLL) comprises a heterogenous group of at least two types of disease entities characterized by distinctive clinical, immunophenotypical and genetic features. The molecular mechanisms underlying the pathogenesis and the histological transformation of CLL are not well known.
Tsirigotis, P, Pappa, V, Labropoulos, S, Papageorgiou, S, Kontsioti, F, Dervenoulas, J, Papageorgiou, E, Panani, A, Mantzios, G, Economopoulos, T, Raptis, S   +10 more
openaire   +3 more sources

Prognostic biomarkers and their impact on treatment strategy selection for patients with advanced stages of oropharyngeal cancer

Medičnì Perspektivi
The study of prognostic biomarkers is crucial for personalising and enhancing the effectiveness of oropharyngeal cancer treatment, as they help identify patients with aggressive disease progression and determine the optimal patient management strategy ...
V.V. Rakhmanov, I.S. Shponka
doaj   +1 more source

Estudo genético do gene p16 pela técnica de PCR-SSCP e expressão de proteína p16 em melanomas de mucosa oral e melanomas cutâneos Genetic analysis of p16 gene by PCR-SSCP technique and protein p16 expression in oral mucosa and skin melanomas

Anais Brasileiros de Dermatologia, 2006
FUNDAMENTOS: A deleção e mutação do gene CDKN2a que codifica um inibidor específico da ciclina dependente de quinase 4, a proteína p16, têm sido implicadas na tumorigênese do melanoma cutâneo. Entretanto, pouco se conhece sobre essas alterações genéticas
Ricardo Hsieh, Fabrício Bitu Sousa, Aline Firmiano, Fabio Daumas Nunes, Marina Helena Cury Gallottini de Magalhães, Mírian Nacagami Sotto   +5 more
doaj   +1 more source

Significance and limitations of routine p16/Ki-67 immunohistochemistry as a diagnostic tool for high-grade squamous intraepithelial lesions of the uterine cervix [PDF]

Obstetrics & Gynecology Science
Objective To evaluate the diagnostic utility and limitations of routine p16 and Ki-67 immunohistochemistry (IHC) in detecting high-grade squamous intraepithelial lesions (HSILs) in the uterine cervix.
Kazutaka Ozono, Fumi Kawakami, Yoshiki Mikami   +2 more
doaj   +1 more source

Evaluation of p16 and Ki67 expression in cervical neoplasm and its association with human papillomavirus infection: An observational study

Journal of Indira Gandhi Institute of Medical Sciences
Introduction: Cervical cancer is the fourth-most common cancer among females associated with strong viral etiology. Nearly 99.7% of cases are associated with persistent high-risk human papillomavirus infection (hr-HPV).
Anila Sinha, Kalpana Chandra, Richa Sharma, Archana Sinha, Nidhi Prasad, Simran Suman, Ayushi Singh   +6 more
doaj   +1 more source

Expression of CCND1, P16 and CDK6 in Human Basal Cell Carcinoma [PDF]

, 2007
Basal cell carcinoma (BCC) is the most common cancer among skin cancers. The incidence of cutaneous malignant melanoma (CMM) and non-melanoma skin cancer (NMSC) has increased more than 600% worldwide since the 1940s.
Eshkoor, Sima Ataollahi
core