Results 111 to 120 of about 3,597,789 (164)

Fermented Porcine Placenta and Its Dipeptides Modulate Cellular Senescence in Human Keratinocytes

Current Issues in Molecular Biology
Skin aging is primarily driven by oxidative stress, mitochondrial dysfunction, and cell cycle dysregulation. This study investigated the anti-senescence effects of fermented porcine placenta (FPP) and its dipeptides, leucine–glycine (LG) and proline ...
Yea Jung Choi, Minseo Kang, Mu Hyun Jin, Jongbae Kim, Won Kyung Lee, Seok-Seon Roh, Ki Sung Kang, Gwi Seo Hwang, Sangki Park, Sullim Lee   +9 more
doaj   +1 more source

RNA splicing variants of the novel long non-coding RNA, CyKILR, possess divergent biological functions in non-small cell lung cancer

Molecular Therapy: Nucleic Acids
The CDKN2A gene, responsible for encoding the tumor suppressors p16(INK4A) and p14(ARF), is frequently inactivated in non-small cell lung cancer (NSCLC). Herein, an uncharacterized long non-coding RNA (lncRNA) (ENSG00000267053) on chromosome 19p13.12 was
Xiujie Xie, H. Patrick Macknight, Amy L. Lu, Charles E. Chalfant   +3 more
doaj   +1 more source

Sodium valproate affects the expression of p16^INK4a and p21^WAFI/Cip1 cyclin‑dependent kinase inhibitors in HeLa cells

Oncology Letters
p16INK4a and p21WAF1/Cip1 are cyclin-dependent kinase inhibitors involved in cell cycle control, which can function as oncogenes or tumor suppressors, depending on the context of various extracellular and intracellular signals, and cell type. In human papillomavirus-induced cervical cancer, p16 INK4a shows oncogenic activity and functions as a ...
Rocha, Marina Amorim, Cardoso, Adauto Lima, Martins, Cesar, Mello, Maria Luiza S.   +3 more
openaire   +2 more sources

Analysis of p16 gene mutations and deletions in childhood acute lymphoblastic leukemias

São Paulo Medical Journal
CONTEXT: The p16 tumor suppressor gene encodes a cyclin-dependent kinase 4 inhibitor that blocks cell division during the G1 phase of the cell cycle. Alterations in this gene have been reported for various neoplasia types, including acute lymphoblastic ...
José Alexandre Rodrigues Lemos, Ricardo Defavery, Carlos Alberto Scrideli, Luiz Gonzaga Tone   +3 more
doaj   +1 more source

Cell cycle-dependent regulation of structure of endoplasmic reticulum and inositol 1,4,5-trisphosphate-induced Ca2+ release in mouse oocytes and embryos [PDF]

, 2003
The organization of endoplasmic reticulum (ER) was examined in mouse eggs undergoing fertilization and in embryos during the first cell cycle. The ER in meiosis 11 (MII)-arrested mouse eggs is characterized by accumulations (clusters) that are restricted
Carroll, J, Marangos, P, FitzHarris, G
core  

Dissecting the determinants of cyclin-dependent kinase 2 and cyclin-dependent kinase 4 inhibitor selectivity

Cyclin dependent kinases are a key family of kinases involved in cell cycle regulation and are an attractive target for cancer chemotherapy. The roles of four residues of the cyclin-dependent kinase active site in inhibitor selectivity were investigated ...
Boyle FT, Pratt DJ, Jewsbury P, Noble MEM, Endicott JA, Bentley J   +5 more
core   +5 more sources

Comparison of senescence progression in mesenchymal cells from human umbilical cord walls measured by immunofluorescence and flow cytometry of p16 and p21

Einstein (São Paulo)
Objective To follow the expansion of mesenchymal stem cells from umbilical cords by two classic senescence markers, p16 (INK4A) and p21 (CDKN1A), using practical, fast, and less expensive methods than the gold standard Western blotting technique, to ...
Aline da Silva, Carla de Azevedo Piccinato, Luiz Roberto Sardinha, Thiago Pinheiro Arrais Aloia, Anna Carla Goldberg   +4 more
doaj   +2 more sources

CDK2 inhibition enhances CDK4/6 inhibitor antitumor activity in comprehensive breast cancer PDX model screen

npj Breast Cancer
Aberrant cyclin-dependent kinase 2 (CDK2) activity is implicated as a resistance mechanism to CDK4/6 inhibitors (CDK4/6i) in hormone receptor–positive (HR+)/human epidermal growth factor receptor 2-negative (HER2−) breast cancer.
Nealia C. House, Maxine M. Chen, Sima Khazaei, Victoria Brown, Philip Ramsden, David H. Peng, Sydney Moore, Liang Yuan, Rentian Wu, Fangyang Wang, Linjie Luo, Ningping Feng, Christopher A. Bristow, Timothy A. Yap, Khandan Keyomarsi, Joseph R. Marszalek, Scott Ribich, Mikael L. Rinne, Lakshmi B. Muthuswamy, Kerrie L. Faia   +19 more
doaj   +1 more source

Humoral immune response to p16, a cyclin-dependent kinase inhibitor in human malignancies

, 2004
The p16 protein is a cyclin-dependent kinase (CDK) inhibitor, which plays an important role in the regulation of the cell cycle by inactivating the cyclin-dependent kinase (CDK) that phosphorylate retinoblastoma (Rb) protein.
Looi, Koksun
core   +1 more source

p53; cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) (CDKN2A; ARF) [PDF]

Science-Business eXchange, 2008
openaire   +1 more source