Results 121 to 130 of about 28,898 (227)

Sodium valproate affects the expression of p16^INK4a and p21^WAFI/Cip1 cyclin‑dependent kinase inhibitors in HeLa cells

Oncology Letters
p16INK4a and p21WAF1/Cip1 are cyclin-dependent kinase inhibitors involved in cell cycle control, which can function as oncogenes or tumor suppressors, depending on the context of various extracellular and intracellular signals, and cell type. In human papillomavirus-induced cervical cancer, p16 INK4a shows oncogenic activity and functions as a ...
Rocha, Marina Amorim, Cardoso, Adauto Lima, Martins, Cesar, Mello, Maria Luiza S.   +3 more
openaire   +2 more sources

RNA splicing variants of the novel long non-coding RNA, CyKILR, possess divergent biological functions in non-small cell lung cancer

Molecular Therapy: Nucleic Acids
The CDKN2A gene, responsible for encoding the tumor suppressors p16(INK4A) and p14(ARF), is frequently inactivated in non-small cell lung cancer (NSCLC). Herein, an uncharacterized long non-coding RNA (lncRNA) (ENSG00000267053) on chromosome 19p13.12 was
Xiujie Xie, H. Patrick Macknight, Amy L. Lu, Charles E. Chalfant   +3 more
doaj   +1 more source

Analysis of p16 gene mutations and deletions in childhood acute lymphoblastic leukemias

São Paulo Medical Journal
CONTEXT: The p16 tumor suppressor gene encodes a cyclin-dependent kinase 4 inhibitor that blocks cell division during the G1 phase of the cell cycle. Alterations in this gene have been reported for various neoplasia types, including acute lymphoblastic ...
José Alexandre Rodrigues Lemos, Ricardo Defavery, Carlos Alberto Scrideli, Luiz Gonzaga Tone   +3 more
doaj   +1 more source

Comparison of senescence progression in mesenchymal cells from human umbilical cord walls measured by immunofluorescence and flow cytometry of p16 and p21

Einstein (São Paulo)
Objective To follow the expansion of mesenchymal stem cells from umbilical cords by two classic senescence markers, p16 (INK4A) and p21 (CDKN1A), using practical, fast, and less expensive methods than the gold standard Western blotting technique, to ...
Aline da Silva, Carla de Azevedo Piccinato, Luiz Roberto Sardinha, Thiago Pinheiro Arrais Aloia, Anna Carla Goldberg   +4 more
doaj   +2 more sources

CDK2 inhibition enhances CDK4/6 inhibitor antitumor activity in comprehensive breast cancer PDX model screen

npj Breast Cancer
Aberrant cyclin-dependent kinase 2 (CDK2) activity is implicated as a resistance mechanism to CDK4/6 inhibitors (CDK4/6i) in hormone receptor–positive (HR+)/human epidermal growth factor receptor 2-negative (HER2−) breast cancer.
Nealia C. House, Maxine M. Chen, Sima Khazaei, Victoria Brown, Philip Ramsden, David H. Peng, Sydney Moore, Liang Yuan, Rentian Wu, Fangyang Wang, Linjie Luo, Ningping Feng, Christopher A. Bristow, Timothy A. Yap, Khandan Keyomarsi, Joseph R. Marszalek, Scott Ribich, Mikael L. Rinne, Lakshmi B. Muthuswamy, Kerrie L. Faia   +19 more
doaj   +1 more source

Oxamate alleviates silicotic fibrosis in mice by inhibiting senescence of alveolar type II epithelial cells

环境与职业医学
BackgroundThe senescence of alveolar type II epithelial cells is an important driving factor for the progression of silicotic fibrosis, and the regulatory effects of oxamate on the senescence of alveolar type II epithelial cells is still unclear ...
Wenjing LIU, Na MAO, Yaqian LI, Xuemin GAO, Zhongqiu WEI, Ying ZHU, Hong XU, Fuyu JIN   +7 more
doaj   +1 more source

Searching for Selective Cyclin-Dependent Kinase Inhibitors to Target the Retinoblastoma/p16 Cancer Gene Pathway [PDF]

JNCI Journal of the National Cancer Institute, 2001
A. Kubo, F. J. Kaye
openaire   +1 more source

p53; cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) (CDKN2A; ARF) [PDF]

Science-Business eXchange, 2008
openaire   +1 more source

Simultaneous inactivation of the p16, p15 and p14 genes encoding cyclin-dependent kinase inhibitors in canine T-lymphoid tumor cells.

The Journal of veterinary medical science, 2014
The p16, p15 and p14 genes are widely known as tumor suppressor genes in human medicine. Although a large number of genetic and epigenetic aberrations in these genes have been reported in human malignancies, canine malignancies have not been well analyzed on the aberrations of these genes.
Aki, Fujiwara-Igarashi, Yuko, Goto-Koshino, Hiroyuki, Mochizuki, Shingo, Maeda, Yasuhito, Fujino, Koichi, Ohno, Hajime, Tsujimoto   +6 more
openaire   +1 more source

Phase I dose-escalation studies of roniciclib, a pan-cyclin-dependent kinase inhibitor, in advanced malignancies [PDF]

, 2017
et al,, Govindan, Ramaswamy
core   +2 more sources