Results 121 to 130 of about 28,797 (249)

Transgenic Expression of the p16INK4a Cyclin-Dependent Kinase Inhibitor Leads to Enhanced Apoptosis and Differentiation Arrest of CD4−CD8− Immature Thymocytes [PDF]

, 2002
Chantal Lagresle‐Peyrou, Betty Gardie, Stéphanie Eyquem, Magali Fasseu, Jean-Claude Vieville, Marika Pla, François Sigaux, Raphaël Borie   +7 more
openalex   +1 more source

Decreased sensitivity of cyclin-dependent kinase 4/6 inhibitors, palbociclib and abemaciclib to canine lymphoma cells with high p16 protein expression and low retinoblastoma protein phosphorylation

, 2022
Leni Maylina, Satoshi Kambayashi, Kenji Baba, Masaya Igase, Takuya Mizuno, Masaru Okuda   +5 more
openalex   +2 more sources

Aberrant p16 methylation as an early diagnostic marker in blood of hepatocellular carcinoma patients

Egyptian Journal of Medical Human Genetics, 2019
Background Alpha-fetoprotein (AFP) is currently used for serologic screening in hepatocellular carcinoma (HCC) but with low sensitivity ranging 41–65% with a high rate of false-negative and false-positive results.
Arig Aly Seif, Heba Hassan Aly, Doaa Mostafa Elzoghby, Ashraf Mohammed Elbreedy, Mohamed Lotfy   +4 more
doaj   +1 more source

Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts

, 2020
Y. Xiong, D. Beach, G. Hannon, D. A. Alcorta, D. Phelps, J. C. Barrett   +5 more
openalex   +1 more source

RNA splicing variants of the novel long non-coding RNA, CyKILR, possess divergent biological functions in non-small cell lung cancer

Molecular Therapy: Nucleic Acids
The CDKN2A gene, responsible for encoding the tumor suppressors p16(INK4A) and p14(ARF), is frequently inactivated in non-small cell lung cancer (NSCLC). Herein, an uncharacterized long non-coding RNA (lncRNA) (ENSG00000267053) on chromosome 19p13.12 was
Xiujie Xie, H. Patrick Macknight, Amy L. Lu, Charles E. Chalfant   +3 more
doaj   +1 more source

Analysis of p16 gene mutations and deletions in childhood acute lymphoblastic leukemias

São Paulo Medical Journal
CONTEXT: The p16 tumor suppressor gene encodes a cyclin-dependent kinase 4 inhibitor that blocks cell division during the G1 phase of the cell cycle. Alterations in this gene have been reported for various neoplasia types, including acute lymphoblastic ...
José Alexandre Rodrigues Lemos, Ricardo Defavery, Carlos Alberto Scrideli, Luiz Gonzaga Tone   +3 more
doaj   +1 more source

Comparison of senescence progression in mesenchymal cells from human umbilical cord walls measured by immunofluorescence and flow cytometry of p16 and p21

Einstein (São Paulo)
Objective To follow the expansion of mesenchymal stem cells from umbilical cords by two classic senescence markers, p16 (INK4A) and p21 (CDKN1A), using practical, fast, and less expensive methods than the gold standard Western blotting technique, to ...
Aline da Silva, Carla de Azevedo Piccinato, Luiz Roberto Sardinha, Thiago Pinheiro Arrais Aloia, Anna Carla Goldberg   +4 more
doaj   +2 more sources

Nucleic acid technology and infectious diseases [PDF]

, 1997
The past decade has witnessed an explosion in the knowledge of microbial genetics, pathogenesis, and antimicrobial resistance as a result of advances in molecular technology.
Luk, WK, Wong, SSY, Woo, PCY, Yuen, KY
core  

Cdkn2a, the cyclin-dependent kinase inhibitor encoding p16^INK4aand p19^ARF, is a candidate for the plasmacytoma susceptibility locus,Pctr1

, 1998
Shuling Zhang, Edward S. Ramsay, Beverly A. Mock   +2 more
openalex   +2 more sources

Oxamate alleviates silicotic fibrosis in mice by inhibiting senescence of alveolar type II epithelial cells

环境与职业医学
BackgroundThe senescence of alveolar type II epithelial cells is an important driving factor for the progression of silicotic fibrosis, and the regulatory effects of oxamate on the senescence of alveolar type II epithelial cells is still unclear ...
Wenjing LIU, Na MAO, Yaqian LI, Xuemin GAO, Zhongqiu WEI, Ying ZHU, Hong XU, Fuyu JIN   +7 more
doaj   +1 more source