Differential Roles for Cyclin-Dependent Kinase Inhibitors p21 and p16 in the Mechanisms of Senescence and Differentiation in Human Fibroblasts [PDF]
Molecular and Cellular Biology, 1999 The irreversible G1 arrest in senescent human diploid fibroblasts is probably caused by inactivation of the G1 cyclin-cyclin-dependent kinase (Cdk) complexes responsible for phosphorylation of the retinoblastoma protein (pRb). We show that the Cdk inhibitor p21(Sdi1,Cip1,Waf1), which accumulates progressively in aging cells, binds to and inactivates ...
Gretchen H. Stein +3 more
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Humoral immune response to p16, a cyclin-dependent kinase inhibitor in human malignancies
Oncology Reports, 2006 The p16 protein is a cyclin-dependent kinase (CDK) inhibitor, which plays an important role in the regulation of the cell cycle by inactivating the cyclin-dependent kinase (CDK) that phosphorylates the retinoblastoma (Rb) protein. Overexpression of p16 protein has been found in many types of human malignancy.
Koksun Looi +5 more
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Expression of the cyclin‐dependent kinase inhibitor p16 during the ongoing cell cycle [PDF]
FEBS Letters, 1995 It has been demonstrated that protein expression of p16, the inhibitor of cyclin‐dependent kinase 4 and 6, increases 4 fold at the G1/S transition when serum‐arrested cells are restimulated to logarithmic growth. We examined the cell cycle regulation of this cyclin‐dependent kinase inhibitor in cells separated according to their cell cycle phases by ...
Thomas Soucek +5 more
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Protective Effect of Multifloral Honey on Stem Cell Aging in a Dynamic Cell Culture Model [PDF]
AntioxidantsNatural compounds, as honey-derived flavonoids and phenolic compounds, are increasingly investigated for their potential to mitigate skin aging and prevent oxidative stress-induced cellular damages.
Fikriye Fulya Kavak +7 more
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p16/Cyclin-Dependent Kinase Inhibitor 2A Deficiency in Human Melanocyte Senescence, Apoptosis, and Immortalization: Possible Implications for Melanoma Progression [PDF]
JNCI Journal of the National Cancer Institute, 2003 The melanoma susceptibility locus cyclin-dependent kinase inhibitor 2A encodes two unrelated cell growth inhibitors, p16 and alternative reading frame (ARF). In fibroblasts, both proteins are implicated in cellular senescence, a key barrier to tumor development. The p16 coding sequence is more often mutated in melanoma families than is the ARF sequence.
Elena V. Sviderskaya +11 more
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Oncology Lettersp16INK4a and p21WAF1/Cip1 are cyclin-dependent kinase inhibitors involved in cell cycle control, which can function as oncogenes or tumor suppressors, depending on the context of various extracellular and intracellular signals, and cell type. In human papillomavirus-induced cervical cancer, p16 INK4a shows oncogenic activity and functions as a ...
Marina Becker Sales Rocha +3 more
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Molecular analysis of the cyclin-dependent kinase inhibitor family: p16(CDKN2/MTS1/INK4A), p18(INK4C) and p27(Kip1) genes in neuroblastomas [PDF]
Cancer, 1996 Chromosomal abnormalities involving band 1p32, especially deletions, are frequent in neuroblastomas, indicating that a tumor suppressor gene(s) is localized at this region. The p18 gene, one of the cyclin-dependent kinase inhibitor (CDKI) genes, maps to this chromosomal region.
Norihiko Kawamata +3 more
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Fermented Porcine Placenta and Its Dipeptides Modulate Cellular Senescence in Human Keratinocytes [PDF]
Current Issues in Molecular BiologySkin aging is primarily driven by oxidative stress, mitochondrial dysfunction, and cell cycle dysregulation. This study investigated the anti-senescence effects of fermented porcine placenta (FPP) and its dipeptides, leucine–glycine (LG) and proline ...
Yea Jung Choi +9 more
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p53; cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) (CDKN2A; ARF) [PDF]
Science-Business eXchange, 2008 openalex +3 more sources
Searching for Selective Cyclin-Dependent Kinase Inhibitors to Target the Retinoblastoma/p16 Cancer Gene Pathway [PDF]
JNCI Journal of the National Cancer Institute, 2001 Akihito Kubo, F Kaye
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