Results 11 to 20 of about 29,685 (221)

Hypertension and age-related focal global glomerulosclerosis are associated with biomarkers for cellular senescence. [PDF]

Physiol Rep
Abstract Arterionephrosclerosis is characterized by focal global glomerulosclerosis (FGGS), which is a constant feature of aging and hypertension. FGGS begins as normal‐appearing glomeruli that undergo tuft contraction (TC) and progress to global glomerulosclerosis (GGS).
Hughson MD, Ali AA, Okabayashi Y, Puelles VG, Bertram JF.   +4 more
europepmc   +2 more sources

Antagonistic interplay between necdin and Bmi1 controls proliferation of neural precursor cells in the embryonic mouse neocortex. [PDF]

PLoS ONE, 2014
Neural precursor cells (NPCs) in the neocortex exhibit a high proliferation capacity during early embryonic development and give rise to cortical projection neurons after maturation.
Ryohei Minamide, Kazushiro Fujiwara, Koichi Hasegawa, Kazuaki Yoshikawa   +3 more
doaj   +1 more source

Oncogenic and Tumor Suppressive Components of the Cell Cycle in Breast Cancer Progression and Prognosis

Pharmaceutics, 2021
Cancer, a disease of inappropriate cell proliferation, is strongly interconnected with the cell cycle. All cancers consist of an abnormal accumulation of neoplastic cells, which are propagated toward uncontrolled cell division and proliferation in ...
Dharambir Kashyap, Vivek Kumar Garg, Elise N. Sandberg, Neelam Goel, Anupam Bishayee   +4 more
doaj   +1 more source

Both p16 and p21 Families of Cyclin-dependent Kinase (CDK) Inhibitors Block the Phosphorylation of Cyclin-dependent Kinases by the CDK-activating Kinase [PDF]

Journal of Biological Chemistry, 1995
Phosphorylation of cyclin-dependent kinases (CDKs) by the CDK-activating kinase is required for the activation of CDK enzymes. Members of two families of CDK inhibitors, p16/p18 and p21/p27, become physically associated with and inhibit the activity of CDKs in response to a variety of growth-modulating signals.
O, Aprelikova, Y, Xiong, E T, Liu
openaire   +2 more sources

Immunocytochemical detection of p16INK4a protein for the identification of patients at risk of cervical cancer [PDF]

Archive of Oncology, 2008
Background: p16INK4a, cyclin-dependent kinase inhibitor that inhibits cyclin dependent kinase 4 and 6, is a product of the INK4a gene, involved in the phosphorylation of the retinoblastoma protein (pRB). HPV E7 protein binds specifically to pRB.
Divani Smaroula, Vardouli Anna, Alexopoulou Vana   +2 more
doaj   +1 more source

Simultaneous Analysis of the p16 Gene and Protein in Canine Lymphoma Cells and Their Correlation with pRb Phosphorylation

Veterinary Sciences, 2022
Cyclin-dependent kinase inhibitor p16 (CDKN2A) primarily functions as a negative regulator of the retinoblastoma protein (pRb) pathway to prevent pRb phosphorylation, thus playing a critical role in cell cycle arrest.
Leni Maylina, Satoshi Kambayashi, Kenji Baba, Masaru Okuda   +3 more
doaj   +1 more source

The emerging role of cellular senescence in renal diseases [PDF]

, 2020
Cellular senescence represents the state of irreversible cell cycle arrest during cell division. Cellular senescence not only plays a role in diverse biological events such as embryogenesis, tissue regeneration and repair, ageing and tumour occurrence ...
Alpini, Gianfranco, Chen, Rong, Francis, Heather, Glaser, Shannon, Li, Siwen, Li, Xuesen, Meng, Fanyin, Wan, Ying, Wu, Nan, Zhang, Chunmei, Zhou, Bingru, Zhou, Tianhao, Zou, Ping   +12 more
core   +1 more source

Dynamic Spatiotemporal Expression Pattern of the Senescence-Associated Factor p16Ink4a in Development and Aging

Cells, 2022
A plethora of factors have been attributed to underly aging, including oxidative stress, telomere shortening and cellular senescence. Several studies have shown a significant role of the cyclin-dependent kinase inhibitor p16ink4a in senescence and aging.
Hasan Safwan-Zaiter, Nicole Wagner, Jean-François Michiels, Kay-Dietrich Wagner   +3 more
doaj   +1 more source

Tissue Microarray Analysis of Cyclin-Dependent Kinase Inhibitors p21 and p16 in Fuchs Dystrophy [PDF]

Cornea, 2013
To investigate the novel application of tissue microarray (TMA) technology to corneal disease and to report altered protein expression of senescence-associated cyclin-dependent kinase inhibitors p21 and p16 in Fuchs endothelial corneal dystrophy (FECD).A TMA including 208 cores was generated from paraffin-embedded tissues, including corneal buttons of ...
Mario, Matthaei, Eva-Maria, Lackner, Huan, Meng, Jessica L, Hicks, Alan K, Meeker, Charles G, Eberhart, Albert S, Jun   +6 more
openaire   +2 more sources

Prevalence of HPV Infection and p16^INK4a Overexpression in Surgically Treated Laryngeal Squamous Cell Carcinoma

Vaccines, 2022
Background: The mucosal high-risk (HR) human papillomavirus (HPV) is associated with oropharyngeal carcinogenesis. Aims of this study were to evaluate the prevalence of HR-HPV infection in laryngeal squamous cell carcinoma (LSCC) from different subsites,
Roberto Gallus, Tarik Gheit, Dana Holzinger, Marco Petrillo, Davide Rizzo, Gianluigi Petrone, Francesco Miccichè, Gian Carlo Mattiucci, Damiano Arciuolo, Giampiero Capobianco, Giovanni Delogu, Vincenzo Valentini, Massimo Tommasino, Francesco Bussu   +13 more
doaj   +1 more source