Results 191 to 200 of about 28,898 (227)

Receptor-Ck regulates the expression of cyclin-dependent kinase inhibitors (p16; p27)

Molecular and Cellular Biochemistry, 1999
The present study was addressed to understand the interrelationship between Receptor-Ck induction-activation coupling; isoprenoids (derived from mevalonate pathway) and cyclin-dependent kinase inhibitors. The results reported here unambiguously reveal that isoprenoids regulate the expression of genes coding for CDK inhibited p16 and p27.
D, Kaul, M, Kaur
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p16 Family Inhibitors of Cyclin-Dependent Kinases

1996
The origin and development of human tumors begins at the molecular level and involves a complex multi-step process. A feature common to many tumor cells is their ability to enter and progress through the cell division cycle under conditions where normal cells would either be quiescent or proliferating at a reduced rate.
Yan Li, Christopher W. Jenkins, Michael A. Nichols, Xiaoyu Wu, Kun-Liang Guan, Yue Xiong   +5 more
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Structural integrity of the cyclin‐dependent kinase inhibitor genes, p15, p16 and p18 in myeloid leukaemias

British Journal of Haematology, 1995
Summary The cyclin‐dependent kinase inhibitors known as p15, p16 and p18 have been suggested as candidates for tumour suppressor genes. We examined these genes for their alterations in 46 myeloid leukaemias and 15 myeloid leukaemia cell lines, p16 mRNA expression was studied in 41 myeloid leukaemias. The p15 and p16 genes were either deleted or mutated
Tsuyoshi Nakamaki, Norihiko Kawamata, Juurg Schwaller, Andreas Tobler, Martin Fey, Seppo Pakkala, Young Y. Lee, Byoung K. Kim, Kunihiko Fukuchi, Nobuyoshi Tsuruoka, Jerry Kahan, Carl W. Miller, H. Phillip Koeffler   +12 more
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Cyclin-dependent kinase inhibitors, p16 and p27, demonstrate different expression patterns in thymoma and thymic carcinoma

General Thoracic and Cardiovascular Surgery, 2014
The role of cell cycle inhibitors in tumorigenesis has been proven in various neoplasms; however, their roles in thymic tumors are still unclear. We examined the expression of cell cycle inhibitors such as those of the Cip/Kip family (p21, p27, and p57) and the INK-4/ARF family (p16 and p14) in thymoma and thymic carcinoma.Samples from 41 thymoma and ...
Mutsuko, Omatsu, Toshiaki, Kunimura, Tetsuya, Mikogami, Akira, Shiokawa, Atsuko, Masunaga, Tomoko, Nagai, Akihiko, Kitami, Takashi, Suzuki, Mitsutaka, Kadokura   +8 more
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Inactivation of the p16 Cyclin-Dependent Kinase Inhibitor in High-Grade Canine Non-Hodgkin's T-Cell Lymphoma

Veterinary Pathology, 2007
The significance of p16/Rb tumor suppressor pathway inactivation in T-cell non-Hodgkin's lymphoma (NHL) remains incompletely understood. We used naturally occurring canine NHL to test the hypothesis that p16 inactivation has specific pathologic correlates. Forty-eight samples (22 T-cell NHL and 26 B-cell NHL) were included.
S P, Fosmire, R, Thomas, C M, Jubala, J W, Wojcieszyn, V E O, Valli, D M, Getzy, T L, Smith, L A, Gardner, M G, Ritt, J S, Bell, K P, Freeman, B E, Greenfield, S E, Lana, W C, Kisseberth, S C, Helfand, G R, Cutter, M, Breen, J F, Modiano   +17 more
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Expression of the p16 and p15 cyclin-dependent kinase inhibitors in lymphocyte activation and neuronal differentiation.

Cancer research, 1995
The cyclin-dependent kinase inhibitors p16INK4/MTS1 and p15INK4B/MTS2 have been mapped to a region in chromosome 9 (921) that is deleted frequently in acute lymphoblastic leukemias and malignant gliomas. To gain insight into the functions of these inhibitors in lymphocytes and neuronal cells, we studied the expression of p15 and p16 during lymphocyte ...
A F, Lois, L T, Cooper, Y, Geng, T, Nobori, D, Carson   +4 more
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Molecular analysis of the cyclin-dependent kinase inhibitor genes, p15, p16, p18 and p19 in the myelodysplastic syndromes

Leukemia Research, 1997
The myelodysplastic syndromes (MDS) are a heterogeneous group of clonal blood disorders characterized by dyshematopoiesis with a frequent evolution to acute leukemia. Chromosomal deletions rather than translocations are the predominant karyotypic abnormalities in MDS, suggesting a recessive mechanism in the pathogenesis of MDS, such as inactivation of ...
T, Nakamaki, C, Bartram, T, Seriu, J, Kahan, K, Fukuchi, N, Tsuruoka, J W, Janssen, C W, Miller, H P, Koeffler   +8 more
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Comparative analysis of Homo sapiens and Mus musculus cyclin-dependent kinase (CDK) inhibitor genes P16 (MTS1) and P15 (MTS2)

Journal of Molecular Evolution, 1995
Cyclin-dependent kinase inhibitors are a growing family of molecules that regulate important transitions in the cell cycle. At least one of these molecules, p16, has been implicated in human tumorigenesis while its close homolog, p15, is induced by cell contact and transforming growth factor-beta (TGF-beta).
P, Jiang, S, Stone, R, Wagner, S, Wang, P, Dayananth, C A, Kozak, B, Wold, A, Kamb   +7 more
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Phenotype‐rescue of cyclin‐dependent kinase inhibitor p16/INK4A defects in a spontaneous canine cell model of breast cancer

Journal of Cellular Biochemistry, 2009
AbstractMammary cancer is among the most frequently observed canine tumors in unspayed female dogs resulting in death due to metastatic disease. These tumors are excellent models of human breast cancer but until recently there was only anecdotal evidence regarding underlying genetic defects.
Patricia, DeInnocentes, Payal, Agarwal, R Curtis, Bird   +2 more
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Frequent homozygous deletion of cyclin‐dependent kinase inhibitor 2 (MTS1, p16) in superficial bladder cancer detected by fluorescence in situ hybridization

Genes, Chromosomes and Cancer, 1997
Deletion of all or part of chromosome 9 is a well-described genetic alteration in bladder tumors. It has been proposed that inactivation of a tumor-suppressor gene on chromosome 9 is an important event in tumor development. Recent reports have supported cyclin-dependent kinase inhibitor 2 (CDKN2, also known as MTS1, INK4, p16) at 9p21 as a candidate ...
M, Balázs, P, Carroll, R, Kerschmann, G, Sauter, F M, Waldman   +4 more
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