Results 21 to 30 of about 28,797 (249)
CDK2 inhibition enhances CDK4/6 inhibitor antitumor activity in comprehensive breast cancer PDX model screen [PDF]
npj Breast CancerAberrant cyclin-dependent kinase 2 (CDK2) activity is implicated as a resistance mechanism to CDK4/6 inhibitors (CDK4/6i) in hormone receptor–positive (HR+)/human epidermal growth factor receptor 2-negative (HER2−) breast cancer.
Nealia C. House +19 more
doaj +2 more sources
P16 expression in human breast carcinoma and its relationship to clinicopathological parameters
Advanced Biomedical Research, 2023 Background: p16 is a cyclin-dependent kinase inhibitor and a cardinal regulator of the cell cycle. The relationship between p16 overexpression and poor prognosis of breast cancer has been reported in some studies.
Fereshteh Mohammadizadeh, Farnaz Nasri
doaj +1 more source
Antagonistic interplay between necdin and Bmi1 controls proliferation of neural precursor cells in the embryonic mouse neocortex. [PDF]
PLoS ONE, 2014 Neural precursor cells (NPCs) in the neocortex exhibit a high proliferation capacity during early embryonic development and give rise to cortical projection neurons after maturation.
Ryohei Minamide +3 more
doaj +1 more source
Pharmaceutics, 2021 Cancer, a disease of inappropriate cell proliferation, is strongly interconnected with the cell cycle. All cancers consist of an abnormal accumulation of neoplastic cells, which are propagated toward uncontrolled cell division and proliferation in ...
Dharambir Kashyap +4 more
doaj +1 more source
Immunocytochemical detection of p16INK4a protein for the identification of patients at risk of cervical cancer [PDF]
Archive of Oncology, 2008 Background: p16INK4a, cyclin-dependent kinase inhibitor that inhibits cyclin dependent kinase 4 and 6, is a product of the INK4a gene, involved in the phosphorylation of the retinoblastoma protein (pRB). HPV E7 protein binds specifically to pRB.
Divani Smaroula +2 more
doaj +1 more source
The emerging role of cellular senescence in renal diseases [PDF]
, 2020 Cellular senescence represents the state of irreversible cell cycle arrest during cell division. Cellular senescence not only plays a role in diverse biological events such as embryogenesis, tissue regeneration and repair, ageing and tumour occurrence ...
Alpini, Gianfranco +12 more
core +1 more source
Veterinary Sciences, 2022 Cyclin-dependent kinase inhibitor p16 (CDKN2A) primarily functions as a negative regulator of the retinoblastoma protein (pRb) pathway to prevent pRb phosphorylation, thus playing a critical role in cell cycle arrest.
Leni Maylina +3 more
doaj +1 more source
Cells, 2022 A plethora of factors have been attributed to underly aging, including oxidative stress, telomere shortening and cellular senescence. Several studies have shown a significant role of the cyclin-dependent kinase inhibitor p16ink4a in senescence and aging.
Hasan Safwan-Zaiter +3 more
doaj +1 more source
Identification of novel therapeutic targets in the PI3K/AKT/mTOR pathway in hepatocellular carcinoma using targeted next generation sequencing. [PDF]
, 2014 Understanding genetic aberrations in cancer leads to discovery of new targets for cancer therapies. The genomic landscape of hepatocellular carcinoma (HCC) has not been fully described. Therefore, patients with refractory advanced/metastatic HCC referred
Janku, Filip +4 more
core +6 more sources
Vaccines, 2022 Background: The mucosal high-risk (HR) human papillomavirus (HPV) is associated with oropharyngeal carcinogenesis. Aims of this study were to evaluate the prevalence of HR-HPV infection in laryngeal squamous cell carcinoma (LSCC) from different subsites,
Roberto Gallus +13 more
doaj +1 more source