Results 1 to 10 of about 33,889 (223)

All-Trans Retinoic Acid Induces DU145 Cell Cycle Arrest through Cdk5 Activation [PDF]

Cellular Physiology and Biochemistry, 2014
Background/Aims: All-trans retinoic acid (ATRA), the active form of vitamin A, plays an important role in the growth arrest of numerous types of cancer cells.
Eugene Lin, Mei-Chih Chen, Chih-Yang Huang, Shih-Lan Hsu, William J. Huang, Mao-Sheng Lin, Jungle Chi-Hsiang Wu, Ho Lin   +7 more
doaj   +10 more sources

Upstream molecular signaling pathways of p27(Kip1) expression: Effects of 4-hydroxytamoxifen, dexamethasone, and retinoic acids [PDF]

Cancer Cell International, 2010
Background p27(Kip1) is a cyclin-dependent kinase inhibitor that inhibits G1-to-S phase transition of the cell cycle. It is known that a relatively large number of nutritional and chemopreventive anti-cancer agents specifically up-regulate expression of ...
Eto Isao
doaj   +3 more sources

Doxycycline regulated induction of AKT in murine prostate drives proliferation independently of p27 cyclin dependent kinase inhibitor downregulation. [PDF]

PLoS ONE, 2012
The PI3 kinase/AKT pathway has been shown to increase degradation of the p27 cyclin dependent kinase inhibitor through phosphorylation of consensus AKT sites on p27 and SKP2, and AKT driven proliferation may be checked by feedback mechanisms that ...
Hongyun Wang, Youyuan Xu, Zi Fang, Sen Chen, Steven P Balk, Xin Yuan   +5 more
doaj   +7 more sources

CDK2 inhibitor BLU-222 synergizes with CDK4/6 inhibitors in drug resistant breast cancers through p21/p27 induction [PDF]

Nature Communications
Cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) combined with endocrine therapy are the standard first-line treatment for hormone receptor-positive, HER2−negative (HR+/HER2−) metastatic breast cancer, but resistance inevitably develops.
Linjie Luo, Yan Wang, Tuyen Bui, Xiaoting Jiang, Mei-Kuang Chen, Xiayu Rao, Sepideh Mohammadhosseinpour, Mi Li, Serena Kim, Rachel Y. Kim, Saba Kamaliasl, Carmen W. Ulizio, Spyros Tsavachidis, Juliana Navarro-Yepes, Nicole M. Kettner, Hannah Wingate, Funda Meric-Bernstam, Kelly K. Hunt, Jing Wang, Kerrie Faia, Khandan Keyomarsi   +20 more
doaj   +2 more sources

RU 486 blocks inhibitory effect of neonatal corticosterone administration on sertoli cell proliferation in mice [PDF]

Scientific Reports
Cortisol/corticosterone (CORT) are typical glucocorticoids and exert an anti-stress function. p27, a cyclin-dependent kinase inhibitor, acts as a terminal factor for Sertoli cell proliferation at the prepubescent stage. Our previous study showed neonatal
Hidenobu Miyaso, Yutaro Natsuyama, Shinichi Kawata, Tomiko Yakura, Zhong-Lian Li, Miyuki Kuramasu, Shota Tanifuji, Xi Wu, Yuki Ogawa, Yoshiharu Matsuno, Masahiro Itoh   +10 more
doaj   +2 more sources

Molecular control of cell density-mediated exit to quiescence

Cell Reports, 2021
Summary: Contact inhibition of cell proliferation regulates tissue size and prevents uncontrolled cell expansion. When cell density increases, contact inhibition can force proliferating cells into quiescence.
Yilin Fan, Tobias Meyer
doaj   +1 more source

Cryo-EM structure of SKP1-SKP2-CKS1 in complex with CDK2-cyclin A-p27KIP1

Scientific Reports, 2023
p27KIP1 (cyclin-dependent kinase inhibitor 1B, p27) is a member of the CIP/KIP family of CDK (cyclin dependent kinase) regulators that inhibit cell cycle CDKs.
Rhianna J. Rowland, Richard Heath, Daniel Maskell, Rebecca F. Thompson, Neil A. Ranson, James N. Blaza, Jane A. Endicott, Martin E. M. Noble, Marco Salamina   +8 more
doaj   +1 more source

Immunohistochemical Expression of p27^Kip1, p57^Kip2, Cyclin D1, Nestin, and Ki-67 in Ependymoma

Brain Sciences, 2022
p27 and p57 are tumor suppressors that are dysregulated in many cancers. We investigated the immunohistochemical expression of p27 and p57 in ependymoma, with a secondary emphasis on cyclin D1, nestin, and Ki-67.
Shahad Iqneibi, Jamil Nazzal, Basma Owda, Hala Sultan, Runa Amoudi, Justin Z. Amarin, Sura Al-Ghnimat, Mamoun Ahram, Maysa Al-Hussaini   +8 more
doaj   +1 more source

A mechanism misregulating p27 in tumors discovered in a functional genomic screen. [PDF]

PLoS Genetics, 2007
The cyclin-dependent kinase inhibitor p27(KIP1) is a tumor suppressor gene in mice, and loss of p27 protein is a negative prognostic indicator in human cancers. Unlike other tumor suppressors, the p27 gene is rarely mutated in tumors.
Carrie M Garrett-Engele, Michael A Tasch, Harry C Hwang, Matthew L Fero, Roger M Perlmutter, Bruce E Clurman, James M Roberts   +6 more
doaj   +1 more source

Regulation of p27 (Kip1) by Ubiquitin E3 Ligase RNF6

Pharmaceutics, 2022
The cyclin-dependent kinase inhibitor p27 (Kip1) is an important regulator of the G1/S checkpoint. It is degraded by the SCF-SKP2 complex in late G1 thereby allowing cells to progress to the S phase.
Dhanraj Deshmukh, Jin Xu, Xi Yang, Hermela Shimelis, Shengyun Fang, Yun Qiu   +5 more
doaj   +1 more source