Results 11 to 20 of about 33,889 (223)

SGK1-Sensitive Regulation of Cyclin-Dependent Kinase Inhibitor 1B (p27) in Cardiomyocyte Hypertrophy [PDF]

Cellular Physiology and Biochemistry, 2015
Background/Aims: The serum- and glucocorticoid-inducible kinase SGK1 participates in the orchestration of cardiac hypertrophy and remodeling. Signaling linking SGK1 activity to cardiac remodeling is, however, incompletely understood. SGK1 phosphorylation
Jakob Voelkl, Tatsiana Castor, Katharina Musculus, Robert Viereck, Sobuj Mia, Martina Feger, Ioana Alesutan, Florian Lang   +7 more
doaj   +3 more sources

Protein Phosphatase 1H, Cyclin-Dependent Kinase Inhibitor p27, and Cyclin-Dependent Kinase 2 in Paclitaxel Resistance for Triple Negative Breast Cancers. [PDF]

J Breast Cancer, 2020
Paclitaxel is a cytotoxic chemotherapy commonly used in patients with triple negative breast cancer (TNBC); however, the resistance to paclitaxel is a cause of poor response in the patients. The aim of this study was to examine the role of protein phosphatase 1H (PPM1H) in paclitaxel resistance in breast cancer patients.To investigate the function of ...
Hur S, Kim JH, Yun J, Ju YW, Han JM, Heo W, Kim K, Jeong K, Lee HB, Han W, Noh DY, Kim JI, Moon HG.   +12 more
europepmc   +4 more sources

BRCA1 transactivates the cyclin-dependent kinase inhibitor p27Kip1 [PDF]

Oncogene, 2002
The p27(Kip1) is a member of the universal cyclin-dependent kinase inhibitor family. Previously, immunochemical analysis of a series of breast cancer cell lines demonstrated a correlation between the expression of p27(Kip1) and the breast cancer susceptibility gene BRCA1. BRCA1 has a number of activities including DNA repair, growth inhibition and as a
Elizabeth A, Williamson, Farnaz, Dadmanesh, H Phillip, Koeffler   +2 more
openaire   +2 more sources

EpoR Activation Stimulates Erythroid Precursor Proliferation by Inducing Phosphorylation of Tyrosine-88 of the CDK-Inhibitor p27^Kip1

Cells, 2023
Erythrocyte biogenesis needs to be tightly regulated to secure oxygen transport and control plasma viscosity. The cytokine erythropoietin (Epo) governs erythropoiesis by promoting cell proliferation, differentiation, and survival of erythroid precursor ...
Fragka Pegka, Nathalie Ben-Califa, Drorit Neumann, Heidelinde Jäkel, Ludger Hengst   +4 more
doaj   +1 more source

The AMPK/p27^Kip1 Pathway as a Novel Target to Promote Autophagy and Resilience in Aged Cells

Cells, 2021
Once believed to solely function as a cyclin-dependent kinase inhibitor, p27Kip1 is now emerging as a critical mediator of autophagy, cytoskeletal dynamics, cell migration and apoptosis.
Lauren K. McKay, James P. White
doaj   +1 more source

Control of Cyclin-Dependent Kinase Inhibitor p27 Expression by Cap-Independent Translation [PDF]

Molecular and Cellular Biology, 2001
p27 is a key regulator of cell proliferation through inhibition of G(1) cyclin-dependent kinase (CDK) activity. Translation of the p27 mRNA is an important control mechanism for determining cellular levels of the inhibitor. Nearly all eukaryotic mRNAs are translated through a mechanism involving recognition of the 5' cap by eukaryotic initiation factor
W K, Miskimins, G, Wang, M, Hawkinson, R, Miskimins   +3 more
openaire   +2 more sources

A Novel Mutation in the Upstream Open Reading Frame of the CDKN1B Gene Causes a MEN4 Phenotype [PDF]

, 2013
PubMed ID: 23555276This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
A Borriello, A Falchetti, A Mehta, A Ozawa, A Wiestner, A Yoon, Alessandro Quattrone, BG Luukkonen, C Le Sage, Carla Scaroni, CC Spevak, CJ Sherr, CJ Sherr, D Malanga, Daniela Regazzo, Denis Ciato, DR Morris, Elena Pardi, Filomena Cetani, Francesca Boaretto, Franco Mantero, G Beffagna, G Johannes, G Occhi, GC Scheper, Giampaolo Trivellin, Gianluca Occhi, Giuseppe Opocher, IM Chu, J Costa-Guda, J Slingerland, K Wethmar, L Liu, L Quintanilla-Martinez, M Georgitsi, M Kozak, M Kozak, M Kullmann, M Matsui, Marshall S. Horwitz, MD Larrea, ML Crowe, ML Fero, Márta Korbonits, Natalia S. Pellegata, NS Pellegata, P Chomczynski, RV Thakker, S Igreja, S Molatore, S Ye, Sara Bobisse, SE Calvo, Sergio Ferasin, SI Reed, SK Agarwal, U Göpfert, Viktoryia Sidarovich, W Zhou, WK Miskimins, Y Wen   +60 more
core   +7 more sources

Establishment of high-throughput screening HTRF assay for identification small molecule inhibitors of Skp2-Cks1

Scientific Reports, 2021
S-phase kinase associated protein 2 (Skp2), a member of the F-box family that constitute the largest known class of ubiquitin E3 specificity components, is responsible for recognizing and recruiting cyclin-dependent kinase inhibitor p27 for its ...
Kaizhao Hu, Xiao-Jing Li, Moges Dessale Asmamaw, Xiaa-Jing Shi, Hong-Min Liu   +4 more
doaj   +1 more source

Modulation of apoptosis by the cyclin-dependent kinase inhibitor p27Kip1 [PDF]

Journal of Clinical Investigation, 1999
Proliferation and apoptosis are increased in many types of inflammatory diseases. A role for the cyclin kinase inhibitor p27(Kip1) (p27) in limiting proliferation has been shown. In this study, we show that p27(-/-) mesangial cells and fibroblasts have strikingly elevated rates of apoptosis, not proliferation, when deprived of growth factors. Apoptosis
K, Hiromura, J W, Pippin, M L, Fero, J M, Roberts, S J, Shankland   +4 more
openaire   +2 more sources

Pharmacological treatment with inhibitors of nuclear export enhances the antitumor activity of docetaxel in human prostate cancer [PDF]

, 2017
Background and aims: Docetaxel (DTX) modestly increases patient survival of metastatic castration-resistant prostate cancer (mCRPC) due to insurgence of pharmacological resistance. Deregulation of Chromosome Region Maintenance (CRM-1)/ exportin-1 (XPO-1)-
Argueta, Christian, BIORDI, ASSUNTA LEDA, Biordi, Leda Assunta, Colapietro, Alessandro, Festuccia, Claudio, Flati, Vincenzo, Gravina, Giovanni Luca, Iorio, Roberto, Kauffman, Michael, Landesman, Yosef, Mancini, Andrea, Marampon, Francesco, Pompili, Simona, Sferra, Roberta, Shacham, Sharon   +14 more
core   +2 more sources