Results 131 to 140 of about 18,481 (166)

Underexpression of cyclin-dependent kinase inhibitor p27 is associated with poor prognosis in serous ovarian carcinomas

International Journal of Oncology, 2001
Reduced expression of a cyclin-dependent kinase inhibitor, p27, has been reported to be associated with poor prognosis in several human cancers. The aim of this study was to investigate the potential role of p27 in ovarian cancer development and progression. Immunohistochemical expression of p27 was determined using 117 epithelial ovarian tumor tissues
K, Shigemasa, Y, Shiroyama, T, Sawasaki, T, Fujii, N, Nagai, T H, Parmley, T J, O'Brien, K, Ohama   +7 more
openaire   +2 more sources

Expression of the cyclin-dependent kinase inhibitor p27 and its deregulation in mouse B cell lymphomas

Leukemia Research, 2006
CDKN1B (p27) regulates cell-cycle progression at the G1-S transition by suppressing the cyclin E/CDK2 kinase complex. In normal lymphocytes and most human B cell non-Hodgkin lymphomas (NHL), there is an inverse correlation between proliferative activity and expression of p27; however, a subset of NHL with high mitotic indices expresses p27, which is ...
Chen-Feng, Qi, Shao, Xiang, Min Sun, Shin, Xingpei, Hao, Chang Hoon, Lee, Jeff X, Zhou, Ted A, Torrey, Janet W, Hartley, Torgny N, Fredrickson, Herbert C, Morse   +9 more
openaire   +2 more sources

Regulation and role of p21 and p27 cyclin-dependent kinase inhibitors during hepatocyte differentiation and growth

American Journal of Physiology-Gastrointestinal and Liver Physiology, 2003
Unlike a large number of cell types that undergo terminal differentiation associated with permanent withdrawal from the cell cycle, mature quiescent hepatocytes retain high proliferative potential. We report here a specific behavior of members of the Cip/Kip family of cyclin-dependent kinase (Cdk) inhibitors during development of the rat liver and ...
Gennady P, Ilyin, Denise, Glaise, David, Gilot, Georges, Baffet, Christiane, Guguen-Guillouzo   +4 more
openaire   +2 more sources

Overexpression of cyclin dependent kinase inhibitor P27/Kip1 increases oligodendrocyte differentiation from induced pluripotent stem cells

In Vitro Cellular & Developmental Biology - Animal, 2014
Cell transplantation therapy with oligodendrocyte precursor cells (OPCs) is a promising and effective treatment for diseases involving demyelination in the central nervous system (CNS). In previous studies, we succeeded in producing O4(+) oligodendrocytes (OLs) from mouse- and human-induced pluripotent stem cells (iPSCs) in vitro; however, the ...
Shinpei, Tamaki, Yasuhito, Tokumoto
openaire   +2 more sources

Cyclin dependent kinase inhibitor p27^Kip1 is upregulated by hypoxia via an ARNT dependent pathway

Journal of Cellular Biochemistry, 2003
AbstractExpression of cyclin dependent kinase (Cdk) inhibitor p27Kip1, which blocks cell cycle progression from G1 to S phase, can be regulated via multiple mechanisms including transcription, protein degradation, and translation. Recently, it was shown that p27Kip1 plays an important role in the cellular response to hypoxia.
Gang, Wang, Richard, Reisdorph, Robert E, Clark, Robin, Miskimins, Ronald, Lindahl, W Keith, Miskimins   +5 more
openaire   +2 more sources

Prognostic role of the cyclin-dependent kinase inhibitor p27 in non-small cell lung cancer.

Cancer research, 1997
Despite its potential role as a tumor suppressor, p27 gene, a member of the Cip/Kip family of cyclin-dependent kinase inhibitor genes, has never been found mutated in human tumors. We investigated p27 protein expression in a series of 108 non-small cell lung cancers (57.4% stage 1, 16.7% stage 2, and 25.9% stage 3) to determine whether the lack or ...
ESPOSITO V, BALDI, Alfonso, DE LUCA, Antonio, GROGER AM, LODA M, GIORDANO GG, CAPUTI M, BALDI F, PAGANO M, GIORDANO A.   +9 more
openaire   +3 more sources

Role of the Ubiquitin-Proteasome Pathway in Regulating Abundance of the Cyclin-Dependent Kinase Inhibitor p27

Science, 1995
The p27 mammalian cell cycle protein is an inhibitor of cyclin-dependent kinases. Both in vivo and in vitro, p27 was found to be degraded by the ubiquitin-proteasome pathway. The human ubiquitin-conjugating enzymes Ubc2 and Ubc3 were specifically involved in the ubiquitination of p27.
PAGANO M., TAM S. W., THEODORAS A. M., BEER ROMERO P., DEL SAL, GIANNINO, CHAU V., YEW P. R., DRAETTA G. F., ROLFE M.   +8 more
openaire   +4 more sources

p27 Expression, a cyclin dependent kinase inhibitor in breast carcinoma.

Advances in clinical pathology : the official journal of Adriatic Society of Pathology, 2000
p27 KIP1 is a cyclin dependent kinase inhibitor, which may act as a potential suppressor gene. Several lines of evidence support the hypothesis that reduced p27 KIP1 expression is related to uncontrolled cell proliferation and tumorigenesis. Low immunohistochemical expression of p27 KIP1 in human neoplasm seems related to tumor progression and poor ...
openaire   +1 more source

Cyclin-dependent kinase inhibitors, p16 and p27, demonstrate different expression patterns in thymoma and thymic carcinoma

General Thoracic and Cardiovascular Surgery, 2014
The role of cell cycle inhibitors in tumorigenesis has been proven in various neoplasms; however, their roles in thymic tumors are still unclear. We examined the expression of cell cycle inhibitors such as those of the Cip/Kip family (p21, p27, and p57) and the INK-4/ARF family (p16 and p14) in thymoma and thymic carcinoma.Samples from 41 thymoma and ...
Mutsuko, Omatsu, Toshiaki, Kunimura, Tetsuya, Mikogami, Akira, Shiokawa, Atsuko, Masunaga, Tomoko, Nagai, Akihiko, Kitami, Takashi, Suzuki, Mitsutaka, Kadokura   +8 more
openaire   +2 more sources

Promoting apoptosis: a novel activity associated with the cyclin-dependent kinase inhibitor p27.

Cancer research, 1998
p27Kip1, a cyclin-dependent kinase inhibitor, is recognized as a negative regulator of the cell cycle. In this paper, we report that overexpression of p27Kip1 triggers apoptosis in several different human cancer cell lines. Using a recombinant adenoviral vector that expresses p27Kip1 (Adp27), we found that overexpression of p27Kip1 in MDA-MB-231 breast
Y, Katayose, M, Kim, A N, Rakkar, Z, Li, K H, Cowan, P, Seth   +5 more
openaire   +1 more source