Results 61 to 70 of about 18,481 (166)

Expression and significance of cyclin D1, cyclin-dependent kinase 4 and cyclin-dependent kinase inhibitor P27 in patients with non-neoplastic epithelial disorders of the vulva. [PDF]

Exp Ther Med, 2023
Liu H, Zhang F, Li Z.
europepmc   +1 more source

A non-canonical role for p27Kip1 in restricting proliferation of corneal endothelial cells during development.

PLoS ONE, 2020
The cell cycle regulator p27Kip1 is a critical factor controlling cell number in many lineages. While its anti-proliferative effects are well-established, the extent to which this is a result of its function as a cyclin-dependent kinase (CDK) inhibitor ...
Dennis M Defoe, Huiying Rao, David J Harris, Preston D Moore, Jan Brocher, Theresa A Harrison   +5 more
doaj   +1 more source

Berberine Inhibits Growth and Induces G1 Arrest and Apoptosis in Human Cholangiocarcinoma QBC939 Cells

Journal of Pharmacological Sciences, 2012
The chemotherapeutic approach using non-toxic natural products may be one of the strategies for the management of the cholangiocarcinoma. Here we report that in vitro treatment of human cholangiocarcinoma QBC939 cells with berberine, a naturally ...
Wei He, Bin Wang, Yun Zhuang, Dong Shao, Kewen Sun, Jianping Chen   +5 more
doaj   +1 more source

Upstream molecular signaling pathways of p27(Kip1) expression: Effects of 4-hydroxytamoxifen, dexamethasone, and retinoic acids

Cancer Cell International, 2010
Background p27(Kip1) is a cyclin-dependent kinase inhibitor that inhibits G1-to-S phase transition of the cell cycle. It is known that a relatively large number of nutritional and chemopreventive anti-cancer agents specifically up-regulate expression of ...
Eto Isao
doaj   +1 more source

Prognostic Importance of Cell Cycle Regulators Cyclin D1 (CCND1) and Cyclin-Dependent Kinase Inhibitor 1B (CDKN1B/p27) in Sporadic Gastric Cancers

Gastroenterology Research and Practice, 2016
Background. Gastric cancer is known for a notable variety in the course of the disease. Clinical factors, such as tumor stage, grade, and localization, are key in patient survival.
Petra Minarikova, Lucie Benesova, Tereza Halkova, Barbora Belsanova, Inna Tuckova, Frantisek Belina, Ladislav Dusek, Miroslav Zavoral, Marek Minarik   +8 more
doaj   +1 more source

Distinct outcomes from targeted perturbations of the multi-subunit SCFSkp2 E3 ubiquitin ligase in blocking Trp53/Rb1-null prostate tumorigenesis

Communications Biology
Identifying effective therapies targeting multi-protein complexes that lack catalytic sites or cofactor pockets remains a long-standing challenge. The proto-oncogene, ubiquitin E3 ligase SCFSkp2, is one such target.
Yingjiao Xue, Liang Zhu, Saumen Karan, Joseph D. Locker, Craig Branch, Jinghang Zhang, Bang Hoang, Juan Pablo Maianti, Hongling Zhao, Edward L. Schwartz   +9 more
doaj   +1 more source

Cyclin-dependent kinase inhibitor 1B (p27; Kip1; CDKN1B; p27Kip1) [PDF]

Science-Business eXchange, 2008
openaire   +1 more source

Absence of cyclin-dependent kinase inhibitor p27 or p18 increases efficiency of iPSC generation without induction of iPSC genomic instability. [PDF]

Cell Death Dis, 2019
Zhan Z, Song L, Zhang W, Gu H, Cheng H, Zhang Y, Yang Y, Ji G, Feng H, Cheng T, Li Y.   +10 more
europepmc   +1 more source

Enhanced Growth of Mice Lacking the Cyclin-Dependent Kinase Inhibitor Function of p27 [PDF]

Cell, 1996
Hiroaki Kiyokawa, Rhonda D Kineman, Katia O Manova-Todorova, Vera C Soares, Eric S Hoffman, Masao Ono, Dilruba Khanam, Adrian C Hayday, Lawrence A Frohman, Andrew Koff   +9 more
openaire   +1 more source

The cyclin-dependent kinase inhibitor p27 facilitates chemosensitivity by promoting ferroptosis in epithelial ovarian cancer. [PDF]

J Biol Chem
Zhu M, Huang L, Sun S, Chen M, Cai J, Zhang Y, Wang L, Cai L, Peng M.   +8 more
europepmc   +1 more source