Results 141 to 150 of about 382,305 (392)

Cyclin A- and cyclin B-dependent protein kinases are regulated by different mechanisms in Xenopus egg extracts. [PDF]

, 1992
Paul R. Clarke, Dagmar Leiss, Michele Pagano, Eric Karsenti   +3 more
openalex   +1 more source

Pharmacologic inhibition of cyclin-dependent kinases 4 and 6 arrests the growth of glioblastoma multiforme intracranial xenografts.

Cancer Research, 2010
Activation of cyclin-dependent kinases 4 and 6 (cdk4/6) occurs in the majority of glioblastoma multiforme (GBM) tumors, and represents a promising molecular target for the development of small molecule inhibitors.
K. Michaud, D. Solomon, E. Oermann, Jung‐Sik Kim, W. Zhong, M. Prados, T. Ozawa, C. James, T. Waldman   +8 more
semanticscholar   +1 more source

RPL6 Interacts with HMGCS1 to Stabilize HIF‐1α by Promoting Cholesterol Production in Hepatocellular Carcinoma

Advanced Science, EarlyView.
The study found that RPL6 is frequently upregulated in HCC tissues with extrahepatic metastasis. Elevated RPL6 bound to and increased the stability of HMGCS1 mRNA, thereby enhancing intracellular cholesterol levels. Subsequently, increased cholesterol promotes cancer metastasis in HCC by stabilizing HIF‐1α protein.
Minli Yang, Shengtao Cheng, Huiying Gu, Shan Zhong, Dapeng Zhang, Xin He, Weixian Chen, Haijun Deng, Jihua Ren, Peng Chen, Ming Tan, Hui Zhang, Fan Li, Zhenzhen Zhang, Yuan Hu, Juan Chen   +15 more
wiley   +1 more source

Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe

Cell Reports, 2018
Summary: Multiple protein kinases regulate cell-cycle progression, of which the cyclin-dependent kinases (CDKs) are thought to act as upstream master regulators.
Matthew P. Swaffer, Andrew W. Jones, Helen R. Flynn, Ambrosius P. Snijders, Paul Nurse   +4 more
doaj  

Cyclin-dependent kinase control of motile ciliogenesis

eLife, 2018
Cycling cells maintain centriole number at precisely two per cell in part by limiting their duplication to S phase under the control of the cell cycle machinery. In contrast, postmitotic multiciliated cells (MCCs) uncouple centriole assembly from cell cycle progression and produce hundreds of centrioles in the absence of DNA replication to serve as ...
Debra J. Wolgemuth, Jeffrey D. Axelrod, Eszter K. Vladar, Eszter K. Vladar, Tim Stearns, Glicella Salazar-De Simone, Xiangyuan Wang, Maxwell L. Saal, Miranda B. Stratton   +8 more
openaire   +5 more sources

A Novel OsMPK6‐OsMADS47‐PPKL1/3 Module Controls Grain Shape and Yield in Rice

Advanced Science, EarlyView.
OsMADS47 is identified as a key regulator governing rice grain morphology. Phosphorylation‐dependent regulation of its activity directs the development of slender versus round grains, modulating both yield and appearance. This mechanism bridges cellular signaling with transcriptional regulation, establishing a molecular framework for grain optimization.
Jingjing Fang, Yan Chun, Fan Zhang, Tingting Guo, Mengmeng Ren, Jinfeng Zhao, Shoujiang Yuan, Wensheng Wang, Yunhai Li, Xueyong Li   +9 more
wiley   +1 more source

Resistance gene-guided genome mining reveals the roseopurpurins as inhibitors of cyclin-dependent kinases. [PDF]

Proc Natl Acad Sci U S A, 2023
Dunbar KL, Perlatti B, Liu N, Cornelius A, Mummau D, Chiang YM, Hon L, Nimavat M, Pallas J, Kordes S, Ng HL, Harvey CJB.   +11 more
europepmc   +1 more source

D-type cyclin-dependent kinase activity in mammalian cells. [PDF]

, 1994
H Matsushime, Dawn E. Quelle, Sheila Shurtleff, Masatoshi Shibuya, Charles J. Sherr, Jun‐ya Kato   +5 more
openalex   +1 more source

Progastrin Promotes Colorectal Cancer Stem Cell‐Like Properties via the Receptor PZR

Advanced Science, EarlyView.
The tumor microenvironment supports colorectal cancer (CRC) progression by maintaining cancer stem cells (CSCs) through progastrin (PG). This study identifies Protein Zero‐Related protein (PZR) as an essential receptor for PG activity, promoting CSC‐like signaling via SHP2/SRC/β‐catenin.
Julie Nguyen, Marie Lafitte, Maud Barbery, Kevin Espie, Maya Jeitany, Romain Larive, Jihane Vitre, Conception Paul, Yvan Boublik, Elise Fourgous, Valérie Simon, Audrey Sirvent, Madeline Neiveyans, Steeve Thirard, Lucile Bansard, Morgan Maillard, Nathalie Coutry, Jacques Colinge, Philippe Jay, Pierre Martineau, Michael Hahne, Julie Pannequin, Serge Roche   +22 more
wiley   +1 more source

TGF-β1 Induces the Cyclin-Dependent Kinase Inhibitor p27Kip1 mRNA and Protein in Murine B Cells [PDF]

, 1998
H Kamesaki, Kimiko Nishizawa, Ginette Y. Michaud, Jeffrey Cossman, Tohru Kiyono   +4 more
openalex   +1 more source