Results 141 to 150 of about 76,308 (284)

Dual blockade of lipid and cyclin-dependent kinases induces synthetic lethality in malignant glioma [PDF]

, 2012
Christine Cheng, W. Clay Gustafson, Elizabeth Charron, Benjamin T. Houseman, Eli R. Zunder, Andrei Goga, Nathanael S. Gray, Brian A. Pollok, Scott A. Oakes, C. David James, Kevan M. Shokat, William A. Weiss, Qi‐Wen Fan   +12 more
openalex   +1 more source

Synergistic Activation of Immunogenic Cell Death and the cGAS–STING Pathway by Engineered Zinc/Manganese‐Based Metal–Organic Framework Nanoplatforms for Colon Cancer Immunotherapy

Advanced Science, EarlyView.
A zinc/manganese (Zn/Mn)‐based metal‐organic framework (MOF) loaded with the STING agonist c‐di‐AMP diammonium (denoted AMP@Zn/Mn‐MOF) was developed to synergistically activate the cGAS‐STING pathway and induce immunogenic cell death. This nanoplatform reprograms the immunosuppressive tumor microenvironment, significantly enhancing anti‐PD‐L1 ...
Bingzi Zhu, Xiaodong Chen, Chang Xu, Xuehua Qian, Binglong Bai, Ji Lin, Wenhai Deng, Xiang Wang, Yuekai Cui, Shengsheng Zhao, Zuoliang Xie, Tao You, Yingpeng Huang, Xian Shen, Xufeng Lu, Weijian Sun   +15 more
wiley   +1 more source

Cyclin-dependent kinases as mediators of aberrant transcription in prostate cancer

Translational Oncology
Transcriptional control of gene expression is fundamental to all cellular processes. Conversely, transcriptional dysregulation is a hallmark of cancer.
Razia Rahman, Luke A. Selth
doaj   +1 more source

Interactions between Pho85 cyclin‐dependent kinase complexes and the Swi5 transcription factor in budding yeast [PDF]

, 2000
Vivien Measday, Helen J. McBride, Jason Moffat, David J. Stillman, Brenda Andrews   +4 more
openalex   +1 more source

Antagonistic effect of cyclin-dependent kinases and a calcium-dependent phosphatase on polyglutamine-expanded androgen receptor toxic gain of function [PDF]

, 2023
Diana Piol, Laura Tosatto, Emanuela Zuccaro, Eric N. Anderson, Antonella Falconieri, María José Polanco, Caterina Marchioretti, Federica Lia, Joseph White, Elisa Bregolin, Giovanni Minervini, Sara Parodi, Xavier Salvatella, Giorgio Arrigoni, Andrea Ballabio, Albert R. La Spada, Silvio C. E. Tosatto, Fabio Sambataro, Diego L. Medina, Udai Bhan Pandey, Manuela Basso, Maria Pennuto   +21 more
openalex   +1 more source

Translational Oncogenomics and Human Cancer Interactome Networks [PDF]

, 2011
An overview of translational, human oncogenomics, transcriptomics and cancer interactomic networks is presented together with basic concepts and potential, new applications to Oncology and Integrative Cancer Biology.
I. C. Baianu
core   +1 more source

Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases

Advanced Science, EarlyView.
This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo, Lanjie Lei, Ying Jin, Lan Su, Shumao Cui, Liyun Shi   +5 more
wiley   +1 more source

Pyrazolo[1,5-a]-1,3,5-triazine as a Purine Bioisostere: Access to Potent Cyclin-Dependent Kinase Inhibitor (R)-Roscovitine Analogue

, 2009
Florence Popowycz, Guy Fournet, Cédric Schneider, Karima Bettayeb, Yoan Ferandin, Cyrile Lamigeon, Òscar M. Tirado, Silvia Mateo‐Lozano, Vicente Notario, Pierre Colas, Philippe Bernard, Laurent Meijer, Benoı̂t Joseph   +12 more
openalex   +1 more source

OS8.6 Sensitivity of human meningioma cells to the cyclin-dependent kinase inhibitor, TG02 [PDF]

, 2019
Émilie Le Rhun, Caroline von Achenbach, Felix Sahm, S S Wang, Marian C. Neidert, Elisabeth J. Rushing, Tracy Lawhon, Hannah Schneider, Andreas von Deimling, Michael Weller   +9 more
openalex   +1 more source

PIK3CA Mutations Downregulate PPT1 to Promote Adipogenesis by Suppressing P300 Depalmitoylation and Phase Separation

Advanced Science, EarlyView.
This study demonstrates that somatic PIK3CA mutations suppress PPT1 expression via activation of the PI3K–AKT–c‐JUN axis. This reduction in PPT1 weakens its interaction with P300, thereby increasing palmitoylation at C1176 of P300 and protecting P300 from lysosomal degradation.
Hongrui Chen, Zening Huang, Rui Chang, Wei Gao, Yajing Qiu, Bin Sun, Chen Hua, Xiaoxi Lin   +7 more
wiley   +1 more source