Results 211 to 220 of about 424,248 (339)

Data from Expression of p16^Ink4a Compensates for <i>p18^Ink4c</i> Loss in Cyclin-Dependent Kinase 4/6–Dependent Tumors and Tissues

, 2023
Matthew R. Ramsey, Janakiraman Krishnamurthy, Xin‐Hai Pei, Chad Torrice, Weili Lin, Daniel R. Carrasco, Keith L. Ligon, Yue Xiong, Norman E. Sharpless   +8 more
openalex   +1 more source

Longitudinal Tumor Size and Survival Modeling for Exposure–Response Analysis of Drugs with Frequent Dose Reductions: Dose Justification of Abemaciclib in Patients with Metastatic Breast Cancer

Clinical Pharmacology &Therapeutics, EarlyView.
Abemaciclib is an oral anticancer drug indicated for treatment of HR+ HER2‐ breast cancer. Dose modifications due to side effects are frequent, thus drug exposures change over time as a result of altering the dose or temporarily withholding abemaciclib treatment.
Emmanuel Chigutsa, Sonya C. Chapman, P. Kellie Turner   +2 more
wiley   +1 more source

Molecular and Immune Microenvironmental Changes Across Endometrial Lesions: A Comprehensive Immunohistochemical and Clinical Analysis of Progression From Benignity to Carcinoma. [PDF]

J Clin Med Res
Metreveli B, Gagua T, Gagua D, Kepuladze S, Burkadze G.   +4 more
europepmc   +1 more source

MicroRNA-494 inhibits nerve growth factor-induced cell proliferation by targeting cyclin D1 in human corneal epithelial cells

, 2017
Dan Wu, Tingting Qian, Jiaxu Hong, Gang Li, Weiyun Shi, Jianjiang Xu   +5 more
openalex   +2 more sources

Supplemental Table 6 from The Genomic Landscape of Intrinsic and Acquired Resistance to Cyclin-Dependent Kinase 4/6 Inhibitors in Patients with Hormone Receptor–Positive Metastatic Breast Cancer

, 2023
Seth A. Wander, Ofir Cohen, Xueqian Gong, Gabriela N. Johnson, Jorge E. Buendia-Buendia, Maxwell R. Lloyd, Dewey Kim, Flora Luo, Pingping Mao, Karla Helvie, Kailey J. Kowalski, Utthara Nayar, Adrienne G. Waks, Stephen H. Parsons, Ricardo Martínez, Lacey M. Litchfield, Xiang S. Ye, Chunping Yu, Valerie M. Jansen, John R. Stille, Patricia S. Smith, Gerard J. Oakley, Quincy S. Chu, Gerald Batist, Melissa E. Hughes, Jill D. Kremer, Levi A. Garraway, Eric P. Winer, Sara M. Tolaney, Nancy U. Lin, Sean G. Buchanan, Nikhil Wagle   +31 more
openalex   +1 more source

The multiple hit model of infantile and epileptic spasms: The 2025 update

Epilepsia Open, EarlyView.
Abstract Objective Infantile and epileptic spasms syndrome (IESS) is a developmental and epileptic encephalopathy manifesting with epileptic spasms and poor neurodevelopmental outcomes. There is an urgent need for the development of more effective and tolerated therapies.
Aristea S. Galanopoulou, Wenzhu B. Mowrey, Wei Liu, Anna Maria Katsarou, Qianyun Li, Oleksii Shandra, Solomon L. Moshé   +6 more
wiley   +1 more source

LncRNA Wee1-AS coordinates oxidative fatty acid metabolism through the activation of mitochondrial CDK1/CYCLIN B1. [PDF]

Signal Transduct Target Ther
Kim HJ, Jeong C, Lee SH, An S, Hyun GH, Lim GY, Kim JY, Lee J, Park MJ, Kwon SW, Kim W, Noh M, Han YH, Lee MO.   +13 more
europepmc   +1 more source

Peptide RL‐QN15 Regulates Functions of Epidermal Stem Cells to Accelerate Skin Wound Regeneration via the FZD8/β‐Catenin Axis

Exploration, EarlyView.
Amphibian‐derived peptide RL‐QN15 activates the Wnt/β‐catenin signaling pathway by interacting with the FZD8 membrane receptor, promoting epidermal stem cells proliferation, migration, stemness, and EMT processes, thus promoting skin wound healing.
Yuansheng Li, Qiuye Jia, Naixin Liu, Saige Yin, Junyuan Wang, Yujing Ding, Yuliu Yang, Ying Peng, Zeqiong Ru, Shaoyang Zhang, Bu'er Qi, Jun Sun, Li He, Ying Wang, Kun Guo, Xinwang Yang   +15 more
wiley   +1 more source

IL-1β Controls Proliferation, Apoptosis, and Necroptosis Through the PI3K/AKT/Src/NF-κB Pathway in Leukaemic Lymphoblasts. [PDF]

Biomedicines
Victoria-Avila ZL, Reyes-Maldonado E, Domínguez-López ML, Vela-Ojeda J, Lozada-Ruiz A, Alemán OR, Lezama RA.   +6 more
europepmc   +1 more source

Cholesterol Metabolism Regulated Nanoliposome Ameliorates Chemo/Photothermal Therapy Reversing CD8+ T Cell Exhaustion

Exploration, EarlyView.
Our work addresses the challenge of treating triple‐negative breast cancer by developing a multifunctional nanoliposome, ictLipo. The goal was to enhance antitumor immunity by combining photothermal therapy and chemotherapy while simultaneously tackling two major roadblocks: immunosuppression from cholesterol in the tumor microenvironment and therapy ...
Panpan Xue, Tingjie Bai, Huilan Zhuang, Angelo H. All, Shuangqian Yan, Xuemei Zeng   +5 more
wiley   +1 more source