Results 231 to 240 of about 483,027 (406)

Approaches to repurposing reverse transcriptase antivirals in cancer

British Journal of Clinical Pharmacology, EarlyView.
This review highlights the role of reverse transcriptase (RT) inhibition in cellular regulation associated with non‐terminal repeat retrotransposons and endogenous retroviruses. Based on their pleiotropic characteristics, RT inhibitors (RTIs) are discussed as potential anticancer agents.
Richard Head, Saiful Islam, Jennifer H. Martin   +2 more
wiley   +1 more source

Transforming growth factor beta effects on expression of G1 cyclins and cyclin-dependent protein kinases.

, 1993
Yan Geng, Robert A. Weinberg
openalex   +1 more source

Expression of N-terminally truncated cyclin B in the Drosophila larval brain leads to mitotic delay at late anaphase [PDF]

, 1994
Georgina Rimmington, Brian Dalby, David M. Glover   +2 more
openalex   +1 more source

Mitochondria and Endoplasmic Reticulum Contact Site as a Regulator of Proteostatic Stress Responses in Neurodegenerative Diseases

BioEssays, EarlyView.
Recent findings indicate that mitochondria‐associated membranes (MAMs), where the endoplasmic reticulum directly contacts the mitochondria, are a novel microdomain essential for cellular homeostasis, including proteostasis. We summarize the disruption of protein homeostasis and MAM alteration in neurodegenerative diseases, then discuss challenges and ...
Seiji Watanabe, Koji Yamanaka
wiley   +1 more source

The A- and B-type cyclins of Drosophila are accumulated and destroyed in temporally distinct events that define separable phases of the G2-M transition.

, 1990
William G. F. Whitfield, Cayetano González, Gabriela Maldonado-Codina, David M. Glover   +3 more
openalex   +1 more source

Immunohistochemical Analysis of Cyclin D1 Protein in Hematopoietic Neoplasms with Special Reference to Mantle Cell Lymphoma [PDF]

, 1994
Shigeo Nakamura, Masao Seto, Shogo Banno, Susumu Suzuki, Takashi Koshikawa, Kuniyoshi Kitoh, Yoshitoyo Kagami, Michinori Ogura, Yasushi Yatabe, M. Kojima, Tadashi Motoori, Toshitada Takahashi, Ryuzo Ueda, Taizan Suchi   +13 more
openalex   +1 more source

Compact Origins and Where to Find Them: ORC's Guide to Genome‐Wide Licensing

BioEssays, EarlyView.
Origin licensing is a key requirement for any eukaryotic cell to initiate DNA replication in S‐phase. Here, we review the most recent findings in the orchestrated action of the origin recognition complex (ORC) to sequentially load two MCM2‐7 helicases onto DNA with a focus on origin architecture and sequencing‐based methods.
Christian Speck, Luitpold Maximilian Reuter   +1 more
wiley   +1 more source

Simian virus 40 large T antigen associates with cyclin A and p33cdk2 [PDF]

, 1993
J P Adamczewski, Julian Gannon, Tim Hunt
openalex   +1 more source

Non-canonical functions of cell cycle cyclins and cyclin-dependent kinases

Nature reviews. Molecular cell biology, 2016
P. Hydbring, Marcos Malumbres, P. Sicinski   +2 more
semanticscholar   +1 more source

Transcription‐Replication Conflicts: Unlocking New Frontiers in Cancer

BioEssays, EarlyView.
Transcription‐replication conflicts (TRCs) constitute a major source of genome instability. Such conflicts are regulated by chromatin, its dysfunction causing replication stress, DNA breaks, and mutations frequently found in cancer. We review the molecular basis of TRCs and chromatin regulation and discuss the clinical potential of targeting TRCs as ...
Aleix Bayona‐Feliu, Andrés Aguilera
wiley   +1 more source