Results 271 to 280 of about 230,940 (319)

A phosphate-binding pocket in cyclin B3 is essential for XErp1/Emi2 degradation in meiosis I. [PDF]

EMBO Rep
Schunk R, Halder M, Schäfer M, Johannes E, Heim A, Boland A, Mayer TU.   +6 more
europepmc   +1 more source

Schisandrin B targets CDK4/6 to suppress proliferation and enhance radiosensitivity in nasopharyngeal carcinoma by inducing cell cycle arrest. [PDF]

Sci Rep
Fang Y, Lv X, Li G, Wang P, Zhang L, Wang R, Jia L, Liang S.   +7 more
europepmc   +1 more source

HOXA1 Contributes to Bronchial Epithelial Cell Cycle Progression by Regulating p21/CDKN1A. [PDF]

Int J Mol Sci
McCluskey E, Velli SK, Kaminski R, Markward T, Leming H, Yu D, Sajjan U.   +6 more
europepmc   +1 more source

Targeting the Menin–KMT2A interaction in leukemia: Lessons learned and future directions

International Journal of Cancer, EarlyView.
Abstract Chromosomal rearrangements involving the Mixed Lineage Leukemia gene (MLL1, KMT2A) are defining a genetically distinct subset in about 10% of human acute leukemias. Translocations involving the KMT2A‐locus at chromosome 11q23 are resulting in the formation of a chimeric oncogene, where the N‐terminal part of KMT2A is fused to a variety of ...
Florian Perner, Jayant Y. Gadrey, Scott A. Armstrong, Michael W. M. Kühn   +3 more
wiley   +1 more source

Models of Early Resistance to CDK4/6 Inhibitors Unveil Potential Therapeutic Treatment Sequencing. [PDF]

Int J Mol Sci
Zapatero-Solana E, Ding Y, Pulliam N, de Dios A, Ortiz-Ruiz MJ, Lallena MJ.   +5 more
europepmc   +1 more source

Therapeutic targeting of chromatin alterations in leukemia and solid tumors

International Journal of Cancer, EarlyView.
Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner, Tobias Berg, Daniel Sasca, Sophie‐Luise Mersiowsky, Jayant Y. Gadrey, Johanna Thomas, Michael W. M. Kühn, Michael Lübbert   +7 more
wiley   +1 more source

Dinaciclib Interrupts Cell Cycle and Induces Apoptosis in Oral Squamous Cell Carcinoma: Mechanistic Insights and Therapeutic Potential. [PDF]

Int J Mol Sci
Oner M, Cheng YC, Soong SW, Cheng PT, Wang YH, Yang SF, Tsai SC, Lin H.   +7 more
europepmc   +1 more source

Carfilzomib inhibits the progression of hepatocellular cancer by upregulating GADD45α expression. [PDF]

Oncol Lett
Chen M, Chen X, Shui Y, Ji C, Guo W.
europepmc   +1 more source

Distinct outcomes from targeted perturbations of the multi-subunit SCF^Skp2 E3 ubiquitin ligase in blocking Trp53/Rb1-null prostate tumorigenesis. [PDF]

Commun Biol
Xue Y, Zhu L, Karan S, Locker JD, Branch C, Zhang J, Hoang B, Maianti JP, Zhao H, Schwartz EL.   +9 more
europepmc   +1 more source

Molecular subtyping and precision therapy for esophageal cancer

Interdisciplinary Medicine, EarlyView.
The molecular typing of esophageal cancer based on genome, transcriptome, proteome, and multi‐omics revealed various molecular features and provided potential targets for the precision therapy. Recent trials have shown that immunotherapy or molecular targeted therapy plus chemoradiotherapy can improve overall survival and progression‐free survival in ...
Guangkun Pei, Zhuoran Liang, Bianli Gu, Linlin Shi, Ze‐Xian Liu, Shegan Gao   +5 more
wiley   +1 more source