Results 291 to 300 of about 403,677 (344)

Genetic variants linked to type 2 diabetes in CDKN1B and TCF7L2 influence survival outcomes in metastatic colorectal cancer

International Journal of Cancer, EarlyView.
What's New? Multiple genetic polymorphisms characteristic of type 2 diabetes (T2D) have been associated with unfavorable prognostic outcomes in individuals with both T2D and metastatic colorectal cancer. This study evaluated the impact of T2D genetic polymorphisms on metastatic colon cancer prognosis in a cohort of non‐diabetic patients.
Raffaella Ruggiero, Alessandro Ottaiano, Madhura Tathode, Roberto Sirica, Annabella Di Mauro, Monica Ianniello, Nadia Petrillo, Massimiliano Berretta, Silvia Zappavigna, Amalia Luce, Michele Caraglia, Giovanni Savarese   +11 more
wiley   +1 more source

Niclosamide: CRL4^AMBRA1 mediated degradation of cyclin D1 following mitochondrial membrane depolarization. [PDF]

RSC Med Chem
Coomar S, Gasser JA, Słabicki M, Donovan KA, Fischer ES, Ebert BL, Gillingham D, Thomä NH.   +7 more
europepmc   +1 more source

Diagnosis and management of gestational trophoblastic disease: 2025 update

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Gestational trophoblastic disease (GTD) arises from abnormal placenta and comprises a spectrum of premalignant to malignant disorders. Changes in the epidemiology of GTD have been noted in various countries. In addition to histology, molecular genetic studies can help in the diagnostic pathway.
Hextan Y. S. Ngan, Michael J. Seckl, Ross S. Berkowitz, Yang Xiang, François Golfier, Paradan K. Sekharan, Antonio Braga, Andrea Garrett   +7 more
wiley   +1 more source

TNF‑α induces premature senescence in tendon stem cells via the NF‑κB and p53/p21/cyclin E/CDK2 signaling pathways. [PDF]

Int J Mol Med
Guo H, Cao H, Lu Q, Gu Z, Feng G.
europepmc   +1 more source

Current Progress in Targeting Human Cytomegalovirus Infection

iLABMED, EarlyView.
This review highlights recent advances in the mechanisms by which human cytomegalovirus (HCMV) maintains its genome in infected cells, as well as the cellular factors and viral antigens that modulate viral reactivation, which reveal potential targets for addressing HCMV infection.
Yonggang Pei, Jun Chen
wiley   +1 more source

Understanding and overcoming CDK4/6 inhibitor resistance in HR+/HER2- metastatic breast cancer: clinical and molecular perspectives. [PDF]

Ther Adv Med Oncol
da Silva JL, Oliveira LJC, de Resende CAA, Reinert T, de Albuquerque LZ, Leite da Silva LF, Mano MS.   +6 more
europepmc   +1 more source

Alterations and mechanistic insights of gut microbiota and its metabolites in type 2 diabetes mellitus and Alzheimer's disease

iMetaOmics, EarlyView.
This narrative review uniquely addresses how gut microbiota‐derived metabolites mediate overlapping pathologies of insulin resistance, neuroinflammation, and amyloidogenesis in type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD), proposing a framework for dual therapeutic targeting.
Guangyi Xu, Yu An, Yage Du, Zhaoming Cao, Jie Zheng, Jingya Wang, Tingyi Li, Xingen Lei, Yanhui Lu   +8 more
wiley   +1 more source

Quitting Your Day Job in Response to Stress: Cell Survival and Cell Death Require Secondary Cytoplasmic Roles of Cyclin C and Med13. [PDF]

Cells
Bauer JR, Robinson TL, Strich R, Cooper KF.   +3 more
europepmc   +1 more source

Akkermansia muciniphila‐derived hypoacylated rough‐type lipopolysaccharides alleviate diet‐induced obesity via activation of TLR4−IL‐23−IL‐22 immune axis

iMeta, EarlyView.
This study demonstrates that hypoacylated, rough‐type lipopolysaccharides (LPS) derived from Akkermansia muciniphila strain HW07 (ALPS) alleviates diet‐induced obesity. ALPS acts as a weak TLR4 agonist and significantly reduces weight gain, improves metabolic parameters, and restores gut barrier integrity in obese mice.
Li Sun, Yuting Zhang, Wang Dong, Jingzu Sun, Tao Wang, Fei Shao, Huanqin Dai, Junjie Han, Wenzhao Wang, Shuo Wang, Tong Zhao, Liangliang Wang, Chang Liu, Shuangjiang Liu, Hongwei Liu   +14 more
wiley   +1 more source

Plasticity of mitotic cyclins in promoting the G2-M transition. [PDF]

J Cell Biol
Crncec A, Lau HW, Ng LY, Ma HT, Mak JPY, Choi HF, Yeung TK, Poon RYC.   +7 more
europepmc   +1 more source