Results 301 to 310 of about 403,677 (344)

Patient‐derived xenograft models in pan‐cancer: From bench to clinic

Interdisciplinary Medicine, EarlyView.
Abstract Patient‐derived xenograft (PDX) models provide a robust preclinical platform that preserves the genetic and phenotypic heterogeneity of patient tumors while mirroring their tumor genetic characteristics, which retain malignant cells and the tumor pathological structure, making them valuable for studying tumor progression and developing ...
Jiatong Li, Ao Gu, Nannan Tang, Gokhan Zengin, Meng‐Yao Li, Yingbin Liu   +5 more
wiley   +1 more source

Nit1 is upregulated in non-small cell lung cancer and promotes cancer cell proliferation and invasion and regulates EMT-related molecules and cyclins. [PDF]

J Cancer
Wang J, Jiang B, Wang X, Liu H, Fan C.
europepmc   +1 more source

Calpain Proteases and the Evolving Signaling Network in Insect Embryonic Patterning

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Insect embryonic Dorsal‐Ventral (DV) patterning relies on the BMP and Toll pathways to different extents. Calcium‐dependent cystein proteases of the Calpain family also exert an important function to pattern the DV axis. In Drosophila, Calpain A cleaves the Cactus/IkappaB inhibitor and modifies Toll signals in ventral regions of the embryo. In Rhodnius
Alison Julio, Helena Araujo
wiley   +1 more source

DDB1 engagement defines the selectivity of S656 analogs for cyclin K degradation over CDK inhibition. [PDF]

EMBO Rep
Moison C, Mendoza-Sanchez R, Gracias D, Schuetz DA, Spinella JF, Girard S, Thavonekham B, Chagraoui J, Durand A, Fortier S, MacRae T, Bonneil E, Rose Y, Mayotte N, Boivin I, Thibault P, Hébert J, Ruel R, Marinier A, Sauvageau G.   +19 more
europepmc   +1 more source

Prognostic value of FDG PET/CT in de novo stage IV breast cancer patients treated with cyclin-dependent kinase 4/6 inhibitors. [PDF]

Breast Cancer Res
Whi W, Shin J, Kim JY, Ahn HK, Park YH, Ahn JS, Lee H.   +6 more
europepmc   +1 more source

The Role of Tumor Budding in Early‐Stage Laryngeal Cancer Treatment Selection

The Laryngoscope, EarlyView.
The search for treatment choices in the treatment of early‐stage laryngeal cancer is still ongoing. In this group with high treatment rates, it is important to be able to predict the unsuccessful group in advance. Tumor budding shows promising results. The failure rate after radiotherapy is high in patients with tumor budding of 2 or more.
Mehmet Birinci, Oğuz Gül, Oğuzhan Okcu, Tuğba Yemiş, Bayram Şen, Metin Çeliker, Çiğdem Öztürk, Özlem Çelebi Erdivanlı   +7 more
wiley   +1 more source

Research Progress of PROTAC-Degraded CDKs in the Treatment of Breast Cancer. [PDF]

Breast Cancer (Dove Med Press)
Zhao K, Zhang J, Yang Z, Wang R, Shi Y, Ji Y, Zhang S, Liu M.   +7 more
europepmc   +1 more source

A sejtek osztódásának aktiválásában és szabályozásában szerepet játszó fehérjék lucernában [PDF]

, 2008
Miskolczi Pál
core  

Protein glycosylation in lung cancer from a mass spectrometry perspective

Mass Spectrometry Reviews, EarlyView.
Abstract Lung cancer is a severe disease for which better diagnostic and therapeutic approaches are urgently needed. Increasing evidence implies that aberrant protein glycosylation plays a crucial role in the pathogenesis and progression of lung cancer.
Mirjam Balbisi, Simon Sugár, Lilla Turiák   +2 more
wiley   +1 more source