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G2 cyclins are required for the degradation of G1 cyclins in yeast
Nature, 1996Progression of the eukaryotic cell cycle is controlled by cyclin-dependent kinases (CDKs). Cdc28, the budding yeast homologue of Cdc2 (Cdk1), is required for both the G1/S and G2/M transitions of the cell cycle. The functional specificity of the Cdc28 kinase is determined by its association with G1 or G2 cyclins.
Marc Blondel, Carl Mann
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Cell, 1990
The gradual accumulation of cyclin in the frog egg induces an abrupt and concerted activation of p34cdc2 that initiates mitosis. Activation is delayed even after the accumulation of cyclin to a critical threshold concentration. We have reproduced these unusual kinetic properties of p34cdc2 activation in vitro using bacterially expressed cyclin proteins
Michael Glotzer +4 more
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The gradual accumulation of cyclin in the frog egg induces an abrupt and concerted activation of p34cdc2 that initiates mitosis. Activation is delayed even after the accumulation of cyclin to a critical threshold concentration. We have reproduced these unusual kinetic properties of p34cdc2 activation in vitro using bacterially expressed cyclin proteins
Michael Glotzer +4 more
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Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1993
Toru Motokura, Andrew Arnold
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Toru Motokura, Andrew Arnold
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Comptes rendus des seances de la Societe de biologie et de ses filiales, 1993
Cell cycle progression is regulated by the sequential activation of cyclins expression and their association to the cyclin dependent kinases (CDK). Several in vitro and in vivo studies indicate that inappropriate cyclin expression (cyclins D, E, A) in the cell, whether or not due to chromosomal rearrangements, can participate in cell transformation ...
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Cell cycle progression is regulated by the sequential activation of cyclins expression and their association to the cyclin dependent kinases (CDK). Several in vitro and in vivo studies indicate that inappropriate cyclin expression (cyclins D, E, A) in the cell, whether or not due to chromosomal rearrangements, can participate in cell transformation ...
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