The plant-specific cyclin-dependent kinase CDKB1;1 and transcription factor E2Fa-DPa control the balance of mitotically dividing and endoreduplicating cells in Arabidopsis [PDF]
Boudolf, Véronique +8 more
core +2 more sources
GSK3i combinatorial treatments affect CDK4/6 and compensatory pathways in 3D preclinical models of pancreatic neuroendocrine tumors. [PDF]
Luca E +8 more
europepmc +1 more source
Caffeic acid suppresses cyclin D1 expression by directly binding to ribosomal protein S5 in colorectal cancer cells. [PDF]
Watanabe M +8 more
europepmc +1 more source
CCNF mutations in amyotrophic lateral sclerosis and frontotemporal dementia [PDF]
De Belleroche, JS
core +1 more source
Somatic cell reprogramming for Parkinson's disease treatment
The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley +1 more source
Erratum: [Corrigendum] Effects of 17-allylamino-17-demethoxygeldanamycin on the induction of apoptosis and cell cycle arrest in HCT-116 cells. [PDF]
Zhao X +8 more
europepmc +1 more source
What's New? Lung squamous cell carcinoma (LUSC) is more aggressive than lung adenocarcinoma, and is most often diagnosed at an advanced stage. Here, the authors evaluated gene expression data from LUSC tumors and came up with gene signatures for 34 genetic abnormalities whose expression changes throughout different precancerous stages. Several of these
Yupei Lin +9 more
wiley +1 more source
Therapeutic advances in HR+/HER2- advanced breast cancer after failure of CDK4/6 inhibitor therapy. [PDF]
Cui M, Xiao J, Ma L, Liang Y, Liang J.
europepmc +1 more source
What's New? The CDK4/6 inhibitor ribociclib in combination with an endocrine‐based therapy has demonstrated significant progression‐free and overall survival benefits in patients with advanced/metastatic HR+/HER2‐ breast cancer in the pivotal MONALEESA trials.
Peter A. Fasching +20 more
wiley +1 more source

