Results 321 to 330 of about 406,416 (358)

A proliferation of cyclins

Trends in Cell Biology, 1992
Cyclins are regulatory subunits of the serine/threonine protein kinases that play key roles in cell cycle control. The roster of known cyclins has expanded significantly in the past year, revealing a large and very diverse family of proteins. Although cyclins were originally characterized by their periodic accumulation during interphase and destruction
D J, Lew, S, I Reed
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Cyclin A and cyclin B1 overexpression in differentiated thyroid carcinoma

Medical Oncology, 2011
Approximately 30% of patients with thyroid nodules have indeterminate or suspicious fine-needle aspiration (FNA) biopsy results. These patients usually undergo thyroidectomy because of cancer risk. Our aim was to determine diagnostic value of cyclin A and cyclin B1 immunohistochemistry added to routine cytology and their expression on histological ...
Asli, Nar, Ozlem, Ozen, Neslihan Bascil, Tutuncu, Beyhan, Demirhan   +3 more
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Plant A-type cyclins†

Plant Molecular Biology, 2000
Although the basic mechanisms which control the progression through the cell cycle appear to be conserved in all higher eukaryotes, the unique features of the plant developmental programme must be somehow reflected in a plant-specific regulation of the factors which control cell division.
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Isolation of a new mitotic-like cyclin from Arabidopsis: complementation of a yeast cyclin mutant with a plant cyclin

Plant Molecular Biology, 1996
Cyclins, a large family of proteins, are the regulatory subunits of cyclin-dependent protein kinase that are essential activators of cell cycle progression in eukaryotes. Here we report isolation of a new cyclin cDNA (cyclbAt) from Arabibopsis cDNA libraries using polymerase chain reaction amplified cyclin-box sequences as probes.
I S, Day, A S, Reddy, M, Golovkin
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Interactions of Cyclins with Cyclin-Dependent Kinases:  A Common Interactive Mechanism

Biochemistry, 1997
The formation of cdk-cyclin complexes has been investigated at the molecular level and quantified using spectroscopic approaches. In the absence of phosphorylation, cdk2, cdc2, and cdk7 form highly stable complexes with their "natural" cyclin partners with dissociation constants in the nanomolar range. In contrast, nonphosphorylated cdc2-cyclin H, cdk2-
Heitz, Frédéric, Morris, May C, Fesquet, Didier, Cavadore, Jean-Claude, Dorée, Marcel, Divita, Gilles   +5 more
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Identification of a novel vertebrate cyclin: cyclin B3 shares properties with both A- and B-type cyclins.

The EMBO Journal, 1994
Cyclins play a key role in controlling progression through the cell cycle. They act as regulatory subunits of p34cdc2/CDC28 and related cyclin-dependent protein kinases (cdks). In vertebrates, cyclins B1 and B2 function during M phase, whereas cyclin A is required for S phase as well as the G2 to M phase transition. Here, we describe the identification
Gallant, P., Nigg, E. A.
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Cyclin I: A New Cyclin Encoded by a Gene Isolated from Human Brain

Experimental Cell Research, 1995
A new member of the cyclin family has been isolated from an equalized cDNA library derived from human forebrain cortex. This putative cyclin, designated cyclin I, contains a typical cyclin box near the N-terminus and a PEST sequence near the C-terminus.
T, Nakamura, R, Sanokawa, Y F, Sasaki, D, Ayusawa, M, Oishi, N, Mori   +5 more
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Cyclin A in nonfunctioning pituitary adenomas

Endocrine, 2020
Assess cyclin A in nonfunctioning pituitary adenomas (NFPA) and compare its expression in non-invasive and non-proliferative tumors with invasive and proliferative tumors (12× higher risk of recurrence).Quantitative real time polymerase chain reaction to analyze cyclin A using normal pituitary gland as reference.
Elisa B. Lamback, Alexandro Guterres, Monique Alvares Barbosa, Carlos Henrique de Azeredo Lima, Debora Aparecida Silva, Aline Helen da Silva Camacho, Leila Chimelli, Leandro Kasuki, Mônica R. Gadelha   +8 more
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FOXM1c is activated by cyclin E/Cdk2, cyclin A/Cdk2, and cyclin A/Cdk1, but repressed by GSK-3α

Biochemical and Biophysical Research Communications, 2006
Two different inhibitory domains, N-terminus and central domain, keep FOXM1c almost inactive despite its strong transactivation domain. Here, we demonstrate that cyclin E/Cdk2, cyclin A/Cdk2, and cyclin A/Cdk1 activate FOXM1c. Cyclin E/Cdk2 does not target its transactivation domain or its DNA-binding domain.
Inken, Wierstra, Jürgen, Alves
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caenorhabditis elegans cyclin a- and b-type genes: A cyclin a multigene family, an ancestral cyclin b3 and differential germline expression

Journal of Cell Science, 1995
ABSTRACT We have cloned cDNAs for Caenorhabditis elegans cyclins A1, B and B3. While cyclins A1 and B are most closely related to either A- or B-type cyclins of other species, cyclin B3 is less related to these cyclins. However, this cyclin is most similar to the recently identified chicken cyclin B3.
Kreutzer, M., Richards, J., De Silva-Udawatta, M., Temenak, J., Knoblich, J., Lehner, C., Bennett, K.   +6 more
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