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Oncogenic activation of cyclin A
Current Opinion in Genetics & Development, 1993Cyclin A associates with both the p34 cdc2 and p33 cdk2 kinases and is involved at two major check-points (G1-S and G2-M) of the cell cycle. The cyclin has been identified in multimeric protein complexes that incorporate the E2F transcription factor, the p33 cdk2 kinase, and p107, which is related to the retinoblastoma protein.
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Aberrant expression of cyclin A and cyclin B1 proteins in oral carcinoma
Journal of Oral Pathology & Medicine, 1999Cyclins play an important role in regulating the passage of dividing cells through critical checkpoints in cell cycle. Aberrant exprssion of cylcin proteins has been found in a number of human cancers, including carcinomas of the head and neck, where amplification of the cyclin D1 gene is a common finding. The obective of this study was to examine cell
J, Kushner +3 more
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Cyclin E-induced replicative stress drives p53-dependent whole-genome duplication
Cell, 2023Eiko Ozono, John Francis Xavier Diffley
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ABERRANT CYCLIN A AND CYCLIN B1 PROTEIN EXPRESSION IN ASTROCYTOMA
Journal of Neuropathology and Experimental Neurology, 1998K. Allan +4 more
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Non-canonical functions of cell cycle cyclins and cyclin-dependent kinases
Nature Reviews Molecular Cell Biology, 2016Per Hydbring +2 more
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Cyclin-dependent kinases and cell-cycle transitions: does one fit all?
Nature Reviews Molecular Cell Biology, 2008Helfrid Hochegger +2 more
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Cyclin D as a therapeutic target in cancer
Nature Reviews Cancer, 2011C Elizabeth Caldon, Andrew Stone
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