Results 61 to 70 of about 2,773,799 (223)
Cyclins and Cyclin Dependent Kinases during Cardiac Development
Molecules and Cells, 1997 The molecular mechanisms that regulate the cardiomyocyte cell cycle and its terminal differentiation remain largely unknown. To determine which cyclins or cyclin dependent kinases (CDKs) are important for cardiomyocyte proliferation, we examined the expression of cyclins and CDKs during normal cardiac development.
Kang, MJ +4 more
openaire +2 more sources
PLoS ONE, 2017 Cyclin G2 (CCNG2) is an atypical cyclin that functions to inhibit cell cycle progression and is often dysregulated in human cancers. We have previously shown that cyclin G2 is highly unstable and can be degraded through the ubiquitin/proteasome pathway ...
Stefanie Bernaudo +4 more
doaj +1 more source
Phosphorylation of Rad9 at serine 328 by cyclin A-Cdk2 triggers apoptosis via interfering Bcl-xL. [PDF]
PLoS ONE, 2012 Cyclin A-Cdk2, a cell cycle regulated Ser/Thr kinase, plays important roles in a variety of apoptoticprocesses. However, the mechanism of cyclin A-Cdk2 regulated apoptosis remains unclear.
Zhuo Zhan +7 more
doaj +1 more source
Cell Cycling Models of Carcinogenesis: A Complex Systems Analysis [PDF]
arXiv, 2004 A new approach to the modular, complex systems analysis of nonlinear dynamics in cell cycling network transformations involved in carcinogenesis is proposed. Carcinogenesis is a complex process that involves dynamically inter-connected biomolecules in the intercellular, membrane, cytosolic, nuclear and nucleolar compartments that form numerous inter ...
arxiv
BMC Cancer, 2012 Background Promoter methylation of the tumor suppressor gene Cyclin A1 could be associated with Human Papillomavirus 16 (HPV16) induced Head and Neck Squamous Cell Carcinoma (HNSCC) and Cervical Carcinoma.
Weiss Daniel +3 more
doaj +1 more source
A critical role for FBXW8 and MAPK in cyclin D1 degradation and cancer cell proliferation. [PDF]
PLoS ONE, 2006 Cyclin D1 regulates G1 progression. Its transcriptional regulation is well understood. However, the mechanism underlying cyclin D1 ubiquitination and its subsequent degradation is not yet clear. We report that cyclin D1 undergoes increased degradation in
Hiroshi Okabe +5 more
doaj +1 more source
Tumor suppressor and anti-inflammatory protein: an expanded view on insulin-degrading enzyme (IDE) [PDF]
arXiv, 2008 In 1994, I conjectured that insulin-degrading enzyme (IDE) acts as an inhibitor of malignant transformation by degrading insulin and thus preventing this major growth-stimulatory hormone from binding and thereby inactivating the retinoblastoma tumor suppressor protein (RB).
arxiv
Cell Division, 2008 Mitogenic induction of cyclin D1, the allosteric regulator of CDK4/6, is a key regulatory event contributing to G1 phase progression. Following the G1/S transition, cyclin D1 activation is antagonized by GSK3β-dependent threonine-286 (Thr-286 ...
Diehl J Alan, Pontano Laura L
doaj +1 more source
Certain amplified genomic-DNA fragments (AGFs) may be involved in cell cycle progression and chloroquine is found to induce the production of cell-cycle-associated AGFs (CAGFs) in Plasmodium falciparum [PDF]
arXiv, 2015 It is well known that cyclins are a family of proteins that control cell-cycle progression by activating cyclin-dependent kinase. Based on our experimental results, we propose here a novel hypothesis that certain amplified genomic-DNA fragments (AGFs) may also be required for the cell cycle progression of eukaryotic cells and thus can be named as cell ...
arxiv
Gastroenterology Research and Practice, 2009 Adenocarcinomas of rectum and colon may be different with regard to the cellular biological basis for cancer development. A material of 246 rectal cancers removed surgically at Akershus University Hospital in the years 1992–2000 was investigated and was ...
Rolf Aamodt +5 more
doaj +1 more source