Results 11 to 20 of about 19,762 (141)
Identification of Novel Cyclin A2 Binding Site and Nanomolar Inhibitors of Cyclin A2-CDK2 Complex [PDF]
Current Computer-Aided Drug Design, 2021 Background: Given the diverse roles of cyclin A2 both in cell cycle regulation and in DNA damage response, identifying small molecule regulators of cyclin A2 activity carries significant potential to regulate diverse cellular processes in both ageing/neurodegeneration and in cancer.
Stephanie S. Kim +4 more
openaire +4 more sources
Cyclin A2 is essential for mouse gonocyte maturation [PDF]
Cell Cycle, 2020 In mammals, male gonocytes are derived from primordial germ cells during embryogenesis, enter a period of mitotic proliferation, and then become quiescent until birth. After birth, the gonocytes proliferate and migrate from the center of testicular cord toward the basement membrane to form the pool of spermatogonial stem cells (SSCs) and establish the ...
Fanhua Ma +5 more
europepmc +5 more sources
Cerebellar cortical lamination and foliation require cyclin A2 [PDF]
Developmental Biology, 2013 The mammalian genome encodes two A-type cyclins, which are considered potentially redundant yet essential regulators of the cell cycle. Here, we tested requirements for cyclin A1 and cyclin A2 function in cerebellar development. Compound conditional loss of cyclin A1/A2 in neural progenitors resulted in severe cerebellar hypoplasia, decreased ...
José Javier Otero +13 more
europepmc +5 more sources
PDZRN3 protects against apoptosis in myoblasts by maintaining cyclin A2 expression [PDF]
Scientific Reports, 2020 AbstractPDZRN3 is a PDZ domain-containing RING-finger family protein that functions in various developmental processes. We previously showed that expression of PDZRN3 is induced together with that of MyoD during the early phase of skeletal muscle regeneration in vivo. We here show that PDZRN3 suppresses apoptosis and promotes proliferation in myoblasts
Takeshi Honda, Makoto Inui
europepmc +5 more sources
Cyclin A2: At the crossroads of cell cycle and cell invasion [PDF]
World Journal of Biological Chemistry, 2015 Cyclin A2 is an essential regulator of the cell division cycle through the activation of kinases that participate to the regulation of S phase as well as the mitotic entry. However, whereas its degradation by the proteasome in mid mitosis was thought to be essential for mitosis to proceed, recent observations show that a small fraction of cyclin A2 ...
Abdelhalim Loukil +5 more
europepmc +6 more sources
Cyclin A2 maintains colon homeostasis and is a prognostic factor in colorectal cancer [PDF]
Journal of Clinical Investigation, 2021 To clarify the function of cyclin A2 in colon homeostasis and colorectal cancer (CRC), we generated mice deficient for cyclin A2 in colonic epithelial cells (CECs). Colons of these mice displayed architectural changes in the mucosa and signs of inflammation, as well as increased proliferation of CECs associated with the appearance of low- and high ...
Guo, Yuchen +25 more
openaire +6 more sources
Cyclin A2 regulates erythrocyte morphology and numbers [PDF]
Cell Cycle, 2016 Cyclin A2 is an essential gene for development and in haematopoietic stem cells and therefore its functions in definitive erythropoiesis have not been investigated. We have ablated cyclin A2 in committed erythroid progenitors in vivo using erythropoietin receptor promoter-driven Cre, which revealed its critical role in regulating erythrocyte morphology
Jayapal, Senthil Raja +10 more
openaire +4 more sources
Cyclin A2 localises in the cytoplasm at the S/G2 transition to activate PLK1 [PDF]
Life Science Alliance, 2017 Cyclin A2 is a key regulator of the cell cycle, implicated both in DNA replication and mitotic entry. Cyclin A2 participates in feedback loops that activate mitotic kinases in G2 phase, but why active Cyclin A2-CDK2 during the S phase does not trigger mitotic kinase activation remains unclear.
Helena Silva Cascales +8 more
openaire +6 more sources
Foci of cyclin A2 interact with actin and RhoA in mitosis [PDF]
Scientific Reports, 2016 AbstractCyclin A2 is a key player in the regulation of the cell cycle. Its degradation in mid-mitosis depends primarily on the ubiquitin-proteasome system (UPS), while autophagy also contributes. However, a fraction of cyclin A2 persists beyond metaphase.
Loukil, Abdelhalim +6 more
openaire +6 more sources
Cyclin A2 modulates kinetochore–microtubule attachment in meiosis II [PDF]
Journal of Cell Biology, 2017 Cyclin A2 is a crucial mitotic Cdk regulatory partner that coordinates entry into mitosis and is then destroyed in prometaphase within minutes of nuclear envelope breakdown. The role of cyclin A2 in female meiosis and its dynamics during the transition from meiosis I (MI) to meiosis II (MII) remain unclear.
Greg FitzHarris +12 more
openaire +5 more sources