Results 11 to 20 of about 45,816 (242)

Cyclin A2 modulates kinetochore-microtubule attachment in meiosis II. [PDF]

J Cell Biol, 2017
Cyclin A2 is a crucial mitotic Cdk regulatory partner that coordinates entry into mitosis and is then destroyed in prometaphase within minutes of nuclear envelope breakdown. The role of cyclin A2 in female meiosis and its dynamics during the transition from meiosis I (MI) to meiosis II (MII) remain unclear.
Zhang QH, Yuen WS, Adhikari D, Flegg JA, FitzHarris G, Conti M, Sicinski P, Nabti I, Marangos P, Carroll J.   +9 more
europepmc   +6 more sources

Loss of Cdk2 and cyclin A2 impairs cell proliferation and tumorigenesis. [PDF]

Cancer Res, 2014
Abstract Cell-cycle inhibition has yet to offer a generally effective approach to cancer treatment, but a full evaluation of different combinations of cell-cycle inhibitors has not been evaluated. Cyclin A2, a core component of the cell cycle, is often aberrantly expressed in cancer where it may impact cell proliferation.
Gopinathan L, Tan SL, Padmakumar VC, Coppola V, Tessarollo L, Kaldis P.   +5 more
europepmc   +5 more sources

Early Development of Mouse Embryos Null Mutant for the Cyclin A2 Gene Occurs in the Absence of Maternally Derived Cyclin A2 Gene Products [PDF]

Developmental Biology, 2000
Progression through the mammalian cell cycle is regulated by the sequential activation and inactivation of the cyclin-dependent kinases. In adult cells, cyclin A2-dependent kinases are required for entry into S and M phases, completion of S phase, and ...
Winston, Nicola, Bourgain-Guglielmetti, Florence, Ciemerych, Maria A., Kubiak, Jacek Z., Senamaud-Beaufort, Catherine, Carrington, Mark, Bréchot, Christian, Sobczak-Thépot, Joëlle   +7 more
core   +7 more sources

Cyclin A2: a genuine cell cycle regulator?

Biomolecular Concepts, 2012
Cyclin A2 belongs to the core cell cycle regulators and participates in the control of both S phase and mitosis. However, several observations suggest that it is also endowed with other functions, and our recent data shed light on its involvement in ...
Bendris Nawal, Loukil Abdelhalim, Cheung Caroline, Arsic Nikola, Rebouissou Cosette, Hipskind Robert, Peter Marion, Lemmers Bénédicte, Blanchard Jean Marie   +8 more
doaj   +3 more sources

Cyclin A2 induces cytokinesis in human adult cardiomyocytes and drives reprogramming in mice [PDF]

npj Regenerative Medicine
Cyclin A2 (CCNA2), a master cell cycle regulator silenced in postnatal cardiomyocytes, promotes cardiac repair in animal models. However, its effect on cytokinesis in adult human cardiomyocytes was previously unknown.
Esmaa Bouhamida, Sangeetha Vadakke-Madathil, Prabhu Mathiyalagan, Amaresh K. Ranjan, Amir Khan, Cherrie D. Sherman, Paul E. Miller, Andre Ghetti, Najah Abi-Gerges, Hina W. Chaudhry   +9 more
doaj   +2 more sources

Interphase APC/C–Cdc20 inhibition by cyclin A2–Cdk2 ensures efficient mitotic entry [PDF]

Nature Communications, 2016
The Anaphase Promoting Complex/Cyclosome (APC/C) and its co-activator Cdc20 regulate mitotic progression, but both are also present in interphase. Here Hein and Nilsson show that Cyclin A2–CDK2 phosphorylates Cdc20 to inhibit APC/C–Cdc20 activity during ...
Jamin B. Hein, Jakob Nilsson
doaj   +2 more sources

Identification of Novel Cyclin A2 Binding Site and Nanomolar Inhibitors of Cyclin A2-CDK2 Complex. [PDF]

Curr Comput Aided Drug Des, 2021
Background: Given the diverse roles of cyclin A2 both in cell cycle regulation and in DNA damage response, identifying small molecule regulators of cyclin A2 activity carries significant potential to regulate diverse cellular processes in both ageing/neurodegeneration and in cancer.
Kim SS, Alves MJ, Gygli P, Otero J, Lindert S.   +4 more
europepmc   +4 more sources

Functional characterization of the diatom cyclin-dependent kinase A2 as a mitotic regulator reveals plant-like properties in a non-green lineage [PDF]

, 2015
Background: Cyclin-dependent kinases (CDKs) are crucial regulators of cell cycle progression in eukaryotes. The diatom CDKA2 was originally assigned to the classical A-type CDKs, but its cell cycle phase-specific transcription at the G2-to-M phase ...
Bowler, Chris, De Veylder, Lieven, Huysman, Marie, Tanaka, Atsuko, Vyverman, Wim   +4 more
core   +4 more sources

Uterine cyclin A2–deficient mice as a model of female early pregnancy loss [PDF]

The Journal of Clinical Investigation
Proper action of the female sex steroids 17β-estradiol (E2) and progesterone (P4) on the endometrium is essential for fertility. Beyond its role in regulating the cell cycle, cyclin A2 (CCNA2) also mediates E2 and P4 signaling in vitro, but a potential ...
Fatimah Aljubran, Katelyn Schumacher, Amanda Graham, Sumedha Gunewardena, Courtney Marsh, Michael Lydic, Kristin Holoch, Warren B. Nothnick   +7 more
doaj   +2 more sources

A KSHV-targeted small molecule efficiently blocks SARS-CoV-2 infection via inhibiting expression of EGFR and Cyclin A2. [PDF]

Emerg Microbes Infect
Dong Z, Wang X, Hu G, Huang Q, Zhang Y, Jia Y, Du S, Zhu C, Wei F, Zhang D, Wang Y, Cai Q.   +11 more
europepmc   +2 more sources