Results 31 to 40 of about 45,816 (242)

Distinct properties of cyclin-dependent kinase complexes containing cyclin A1 and cyclin A2 [PDF]

Biochemical and Biophysical Research Communications, 2008
The distinct expression patterns of the two A-type cyclins during spermatogenesis and the absolute requirement for cyclin A1 in this biological process in vivo suggest that they may confer distinct biochemical properties to their CDK partners. We therefore compared human cyclin A1- and cyclin A2-containing CDK complexes in vitro by determining kinetic ...
Ayesha R. Joshi, Vaidehi Jobanputra, Karen M. Lele, Debra J. Wolgemuth   +3 more
openalex   +3 more sources

PDZRN3 protects against apoptosis in myoblasts by maintaining cyclin A2 expression. [PDF]

Sci Rep, 2020
AbstractPDZRN3 is a PDZ domain-containing RING-finger family protein that functions in various developmental processes. We previously showed that expression of PDZRN3 is induced together with that of MyoD during the early phase of skeletal muscle regeneration in vivo. We here show that PDZRN3 suppresses apoptosis and promotes proliferation in myoblasts
Honda T, Inui M.
europepmc   +4 more sources

An intron-retaining splice variant of human cyclin A2, expressed in adult differentiated tissues, induces a G1/S cell cycle arrest in vitro. [PDF]

PLoS ONE, 2012
BACKGROUND: Human cyclin A2 is a key regulator of S phase progression and entry into mitosis. Alternative splice variants of the G1 and mitotic cyclins have been shown to interfere with full-length cyclin functions to modulate cell cycle progression and ...
Arata Honda, Yannick Valogne, Myriam Bou Nader, Christian Bréchot, Jamila Faivre   +4 more
doaj   +1 more source

Argininosuccinate lyase interacts with cyclin A2 in cytoplasm and modulates growth of liver tumor cells. [PDF]

Oncol Rep, 2017
Hung YH, Huang HL, Chen WC, Yen MC, Cho CY, Weng TY, Wang CY, Chen YL, Chen LT, Lai MD.   +9 more
europepmc   +3 more sources

Cyclin A2, Rho GTPases and EMT [PDF]

Small GTPases, 2012
Cell cycle regulators, such as cyclins, are often upregulated in many proliferative disorders, and Cyclin A2 is generally considered as a marker of aggressive cancers. Our recent work, which revealed decreased expression of Cyclin A2 upon metastasis of colorectal cancer, suggests a more complicated situation.
Bendris, Nawal, Arsic, Nikola, Lemmers, Bénédicte, Blanchard, Jean Marie   +3 more
openaire   +2 more sources

Cerebellar cortical lamination and foliation require cyclin A2. [PDF]

Dev Biol, 2014
The mammalian genome encodes two A-type cyclins, which are considered potentially redundant yet essential regulators of the cell cycle. Here, we tested requirements for cyclin A1 and cyclin A2 function in cerebellar development. Compound conditional loss of cyclin A1/A2 in neural progenitors resulted in severe cerebellar hypoplasia, decreased ...
Otero JJ, Kalaszczynska I, Michowski W, Wong M, Gygli PE, Gokozan HN, Griveau A, Odajima J, Czeisler C, Catacutan FP, Murnen A, Schüller U, Sicinski P, Rowitch D.   +13 more
europepmc   +3 more sources

Cyclin A2, a novel regulator of EMT. [PDF]

Cell Mol Life Sci, 2014
Our previous work showed that Cyclin A2 deficiency promotes cell invasion in fibroblasts. Given that the majority of cancers emerge from epithelia, we explored novel functions for Cyclin A2 by depleting it in normal mammary epithelial cells. This caused an epithelial to mesenchymal transition (EMT) associated with loss of cell-to-cell contacts ...
Bendris N, Cheung CT, Leong HS, Lewis JD, Chambers AF, Blanchard JM, Lemmers B.   +6 more
europepmc   +3 more sources

TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk

Hepatology, EarlyView., 2022
The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam, Jianqing Yu, Hao Huang, Xiaofan Ding, Alissa M. Wong, Howard H. Leung, Anthony W. Chan, Kelvin K. Ng, Mingjing Xu, Xin Wang, Nathalie Wong   +10 more
wiley   +1 more source

Foci of cyclin A2 interact with actin and RhoA in mitosis. [PDF]

Sci Rep, 2016
AbstractCyclin A2 is a key player in the regulation of the cell cycle. Its degradation in mid-mitosis depends primarily on the ubiquitin-proteasome system (UPS), while autophagy also contributes. However, a fraction of cyclin A2 persists beyond metaphase.
Loukil A, Izard F, Georgieva M, Mashayekhan S, Blanchard JM, Parmeggiani A, Peter M.   +6 more
europepmc   +4 more sources

Bioluminescence imaging of DNA synthetic phase of cell cycle in living animals. [PDF]

PLoS ONE, 2013
Bioluminescence reporter proteins have been widely used in the development of tools for monitoring biological events in living cells. Currently, some assays like flow cytometry analysis are available for studying DNA synthetic phase (S-phase) targeted ...
Zhi-Hong Chen, Rui-Jun Zhao, Rong-Hui Li, Cui-Ping Guo, Guo-Jun Zhang   +4 more
doaj   +1 more source