Transcriptional Regulation of Cyclin A2 by RASSF1A through the Enhanced Binding of p120E4F to the Cyclin A2 Promoter [PDF]
Cancer Research, 2005 Abstract Recent advances in the study of RASSF1A, the candidate tumor suppressor gene, indicate a possible role of RASSF1A in cell cycle regulation; however, very little is known regarding molecular mechanisms underlying this control. Using small interfering RNA to knockdown endogenous RASSF1A in the breast tumor cell line HB2 and in the
Farida Latif +6 more
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Cyclin A2 promotes DNA repair in the brain during both development and aging [PDF]
Aging (Albany NY), 2016 Patrick Gygli +16 more
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A KSHV-targeted Small Molecule Efficiently Blocks SARS-CoV-2 Infection via Inhibiting Expression of EGFR and Cyclin A2 [PDF]
Emerg Microbes InfectZhongwei Dong +11 more
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Cyclin A2 Regulates Nuclear-Envelope Breakdown and the Nuclear Accumulation of Cyclin B1 [PDF]
Current Biology, 2007 Mitosis is thought to be triggered by the activation of Cdk-cyclin complexes. Here we have used RNA interference (RNAi) to assess the roles of three mitotic cyclins, cyclins A2, B1, and B2, in the regulation of centrosome separation and nuclear-envelope breakdown (NEB) in HeLa cells.
Jason W. Myers +7 more
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The double dealing of cyclin D1 [PDF]
Cell Cycle, Taylor & Francis, 2010, pp.1-16, 2020 The cell cycle is tightly regulated by cyclins and their catalytic moieties, the cyclin-dependent kinases (CDKs). Cyclin D1, in association with CDK4/6, acts as a mitogenic sensor and integrates extracellular mitogenic signals and cell cycle progression.
arxiv +1 more source
Myocardial regeneration therapy for ischemic cardiomyopathy with cyclin A2 [PDF]
The Journal of Thoracic and Cardiovascular Surgery, 2007 Heart failure therapies ranging from revascularization to remodeling to replacement are variably effective. Theoretically, endogenous repair via myocardial regeneration would be an ideal therapy. This study examined the ability to initiate regeneration by adenoviral-mediated expression of the cell cycle regulator cyclin A2.
Erik E. Suarez +6 more
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Cyclin A2: a genuine cell cycle regulator?
BioMolecular Concepts, 2012 AbstractCyclin A2 belongs to the core cell cycle regulators and participates in the control of both S phase and mitosis. However, several observations suggest that it is also endowed with other functions, and our recent data shed light on its involvement in cytoskeleton dynamic and cell motility.
Bendris, Nawal +8 more
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Shear-Induced Unfolding Activates von Willebrand Factor A2 Domain for Proteolysis [PDF]
J. Thromb. Haemost. 2009 (7), 2096-2105, 2009 To avoid pathological platelet aggregation by von Willebrand factor (VWF), VWF multimers are regulated in size and reactivity for adhesion by ADAMTS13-mediated proteolysis in a shear flow dependent manner. We examined if tensile stress in VWF under shear flow activates the VWF A2 domain for cleavage by ADAMTS13 using molecular dynamics simulations.
arxiv +1 more source
Membrane‐anchored cyclin A2 triggers Cdc2 activation in Xenopus oocyte [PDF]
FEBS Letters, 2001 In Xenopus oocyte, the formation of complexes between neosynthesized cyclins and Cdc2 contributes to Cdc2 kinase activation that triggers meiotic divisions. It has been proposed that cytoplasmic membranes could be involved in this process. To investigate this possibility, we have injected in the oocyte two undegradable human cyclin A2 mutants anchored ...
Faivre, J. +6 more
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The NFAT1 Transcription Factor is a Repressor of Cyclin A2 Gene Expression [PDF]
Cell Cycle, 2007 The NFAT (Nuclear Factor of Activated T cells) family of transcription factors plays a central role in the regulation of several genes related to the immune response. Recently, NFAT proteins have been implicated in the proliferation and differentiation of different cell types.
Anjana Rao +6 more
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