Morphological analysis of CDC2 and glycogen synthase kinase 3β phosphorylation as markers of g2 → m transition in glioma. [PDF]
, 2011 G2 → M transition is a strategic target for glioma chemotherapy. Key players in G2 → M transition include CDC2 and glycogen synthase kinase 3β (GSK3β), which are highly regulated by posttranslational phosphorylation.
Otero, José Javier, Tihan, Tarik
core +3 more sources
eIF4A inhibitors suppress cell-cycle feedback response and acquired resistance to CDK4/6 inhibition in cancer [PDF]
, 2019 CDK4/6 inhibitors are FDA-approved drugs for estrogen receptor-positive (ER+) breast cancer and are being evaluated to treat other tumor types, including KRAS-mutant non-small cell lung cancer (NSCLC).
Cencic, Regina +13 more
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The cancer preventive activity and mechanisms of prenylated resveratrol and derivatives
Current Research in Toxicology, 2023 Resveratrol is regarded as neutraceuticals with multiple health benefits. The introduction of prenyl can enhance the bioactivity. In this work, the cancer preventive activities and mechanisms of 18 prenylated reseveratrol and derivatives were ...
Ting Zhou +3 more
doaj +1 more source
DHX33 transcriptionally controls genes involved in the cell cycle [PDF]
, 2016 The RNA helicase DHX33 has been shown to be a critical regulator of cell proliferation and growth. However, the underlying mechanisms behind DHX33 function remain incompletely understood.
Fan, Chunyan +7 more
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Exendin-4 Stimulation of Cyclin A2 in β-Cell Proliferation [PDF]
Diabetes, 2008 OBJECTIVE—β-Cell proliferation is an important mechanism underlying β-cell mass adaptation to metabolic demands. We have examined effects, in particular those mediated through intracellular cAMP signaling, of the incretin hormone analog exendin-4 on cell cycle regulation in β-cells.
Song, Woo-Jin +6 more
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Gastroenterology Research and Practice, 2009 Adenocarcinomas of rectum and colon may be different with regard to the cellular biological basis for cancer development. A material of 246 rectal cancers removed surgically at Akershus University Hospital in the years 1992–2000 was investigated and was ...
Rolf Aamodt +5 more
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A data-driven, mathematical model of mammalian cell cycle regulation. [PDF]
PLoS ONE, 2014 Few of >150 published cell cycle modeling efforts use significant levels of data for tuning and validation. This reflects the difficultly to generate correlated quantitative data, and it points out a critical uncertainty in modeling efforts. To develop a
Michael C Weis +3 more
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The tumor-associated YB-1 protein: new player in the circadian control of cell proliferation [PDF]
, 2016 Correct spatial and temporal control of cell proliferation is of fundamental importance for tissue homeostasis. Its deregulation has been associated with several pathological conditions.
Calabrò, Viola +9 more
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Membrane‐anchored cyclin A2 triggers Cdc2 activation in Xenopus oocyte [PDF]
FEBS Letters, 2001 In Xenopus oocyte, the formation of complexes between neosynthesized cyclins and Cdc2 contributes to Cdc2 kinase activation that triggers meiotic divisions. It has been proposed that cytoplasmic membranes could be involved in this process. To investigate this possibility, we have injected in the oocyte two undegradable human cyclin A2 mutants anchored ...
Faivre, J. +6 more
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Inflammatory responses in primary muscle cell cultures in Atlantic salmon (Salmo salar) [PDF]
, 2013 Peer reviewedPublisher ...
Martin, Samuel A.M. +3 more
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