Results 151 to 160 of about 470,056 (173)

Cyclin Y interacts with Chk1 to activate RRM2/STAT3 signaling and promotes radioresistance in non-small cell lung cancer. [PDF]

Int J Biol Sci
Liu Z, Xue H, Wang Z, Zhao Y, Xu S, Dong X.   +5 more
europepmc   +1 more source

Schisandrin B targets CDK4/6 to suppress proliferation and enhance radiosensitivity in nasopharyngeal carcinoma by inducing cell cycle arrest. [PDF]

Sci Rep
Fang Y, Lv X, Li G, Wang P, Zhang L, Wang R, Jia L, Liang S.   +7 more
europepmc   +1 more source

Profiling the Activity of the Potent and Highly Selective CDK2 Inhibitor BLU-222 Reveals Determinants of Response in CCNE1-Aberrant Ovarian and Endometrial Tumors. [PDF]

Cancer Res
House NC, Brown VE, Chen M, Yuan L, Moore SL, Guo J, Choi YJ, Muthuswamy L, Ribich S, Ramsden P, Faia KL.   +10 more
europepmc   +1 more source

Correction: INHBA gene silencing inhibits proliferation, migration, and invasion of osteosarcoma cells by repressing TGF‑β signaling pathway activation. [PDF]

J Orthop Surg Res
Zhang H, Huang Y, Wen Q, Li Y, Guo L, Ge N.   +5 more
europepmc   +1 more source

Inhibition of Cyclin D1 by Novel Biguanide Derivative YB-004 Increases the Sensitivity of Bladder Cancer to Olaparib via Causing G0 / G1 Arrest. [PDF]

Int J Biol Sci
Xiao D, Chu X, Wang W, Peng M, Lv Q, Xu C, Duan H, Yang X.   +7 more
europepmc   +1 more source

Cyclin D1 expression in B-cell lymphomas [PDF]

Experimental Hematology, 2010
Cyclin D1, an important component of cell cycle machinery and a protein with known oncogenic potential, is downregulated in normal mature B lymphocytes. Its expression detected in a number of malignancies, including B-cell lymphomas, may be important for oncogenesis.In our work, we determined the level of cyclin D1 expression in various B-cell ...
Aleena Gladkikh, Elena Korneva, Ivan A. Vorobjev, Daria M. Potashnikova, Olga Khudoleeva   +4 more
openaire   +2 more sources

Homology Model of the CDK1/cyclin B Complex [PDF]

Journal of Biomolecular Structure and Dynamics, 2005
We describe a refined homology model of a CDK1/cyclin B complex that was previously used for the structure-based optimization of the Paullone class of inhibitors. The preliminary model was formed from the homologous regions of the deposited CDK2/cyclin A crystal structure. Further refinement of the CDK1/cyclin B complex was accomplished using molecular
Nagarajan Pattabiraman, Daniel W. Zaharevitz, Edward A. Sausville, Glen E. Kellogg, Conrad Kunick, Rick Gussio, Thomas Lemcke, Connor F. McGrath   +7 more
openaire   +2 more sources

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Identification of a novel vertebrate cyclin: cyclin B3 shares properties with both A- and B-type cyclins.

The EMBO Journal, 1994
Cyclins play a key role in controlling progression through the cell cycle. They act as regulatory subunits of p34cdc2/CDC28 and related cyclin-dependent protein kinases (cdks). In vertebrates, cyclins B1 and B2 function during M phase, whereas cyclin A is required for S phase as well as the G2 to M phase transition. Here, we describe the identification
Gallant, P., Nigg, E. A.
openaire   +3 more sources