Results 151 to 160 of about 13,222,515 (326)

Counteraction between Astrin-PP1 and Cyclin-B-CDK1 pathways protects chromosome-microtubule attachments independent of biorientation. [PDF]

Nat Commun, 2021
Song X, Conti D, Shrestha RL, Braun D, Draviam VM.   +4 more
europepmc   +1 more source

Regulation of the catalytic subunit (p34PSK-J3/cdk4) for the major D-type cyclin in mature B lymphocytes. [PDF]

, 1996
Debra A. Tanguay, Thomas C. Chiles
openalex   +1 more source

A Novel OsMPK6‐OsMADS47‐PPKL1/3 Module Controls Grain Shape and Yield in Rice

Advanced Science, EarlyView.
OsMADS47 is identified as a key regulator governing rice grain morphology. Phosphorylation‐dependent regulation of its activity directs the development of slender versus round grains, modulating both yield and appearance. This mechanism bridges cellular signaling with transcriptional regulation, establishing a molecular framework for grain optimization.
Jingjing Fang, Yan Chun, Fan Zhang, Tingting Guo, Mengmeng Ren, Jinfeng Zhao, Shoujiang Yuan, Wensheng Wang, Yunhai Li, Xueyong Li   +9 more
wiley   +1 more source

The Novel Cyclin-Dependent Kinase Inhibitor Flavopiridol Downregulates Bcl-2 and Induces Growth Arrest and Apoptosis in Chronic B-Cell Leukemia Lines [PDF]

, 1997
Andrea König, Gary K. Schwartz, Ramzi M. Mohammad, Ayad Al‐Katib, Janice Gabrilove   +4 more
openalex   +1 more source

A Glycoproteome Data Mining Strategy for Characterizing Structural Features of Altered Glycans with Thymic Involution

Advanced Science, EarlyView.
This study presents a comprehensive data mining strategy for in‐depth extraction of overall and altered glycan features from structural and site‐specific glycoproteome data across various biomedical samples. The strategy enables the uncovery of four major altered glycan features associated with thymic involution and reveals their coordinated ...
Zhida Zhang, Yongqi Wu, Ke Hou, Yiwen Zhang, Lin Chen, Muyao Yang, Zhehui Jin, Yongchao Xu, Yingjie Zhang, Yinli Cai, Jiayu Zhao, Shisheng Sun   +11 more
wiley   +1 more source

Progastrin Promotes Colorectal Cancer Stem Cell‐Like Properties via the Receptor PZR

Advanced Science, EarlyView.
The tumor microenvironment supports colorectal cancer (CRC) progression by maintaining cancer stem cells (CSCs) through progastrin (PG). This study identifies Protein Zero‐Related protein (PZR) as an essential receptor for PG activity, promoting CSC‐like signaling via SHP2/SRC/β‐catenin.
Julie Nguyen, Marie Lafitte, Maud Barbery, Kevin Espie, Maya Jeitany, Romain Larive, Jihane Vitre, Conception Paul, Yvan Boublik, Elise Fourgous, Valérie Simon, Audrey Sirvent, Madeline Neiveyans, Steeve Thirard, Lucile Bansard, Morgan Maillard, Nathalie Coutry, Jacques Colinge, Philippe Jay, Pierre Martineau, Michael Hahne, Julie Pannequin, Serge Roche   +22 more
wiley   +1 more source

TGF-β1 Induces the Cyclin-Dependent Kinase Inhibitor p27Kip1 mRNA and Protein in Murine B Cells [PDF]

, 1998
H Kamesaki, Kimiko Nishizawa, Ginette Y. Michaud, Jeffrey Cossman, Tohru Kiyono   +4 more
openalex   +1 more source

Comprehensive Characterization of the Immune Microenvironment Based on Nested Resampling Machine Learning Framework Identifies TRAF3 Interacting Protein 3 as a Promising Regulator to Improve the Resistance to Immunotherapy in Glioma

Advanced Science, EarlyView.
This study develops a nested resampling machine learning framework to establish the Immune Glioma Survival Signature (IGLoS), which stratifies glioma patients and predicts immunotherapy resistance. Multi‐omics analyses reveal TRAF3IP3 as a pivotal regulator of PD‐L1 expression and T‐cell exhaustion via ERK‐NFATC2 signaling.
Yanbo Yang, Fei Wang, Yulian Zhang, Run Huang, Chuanpeng Zhang, Lu Zhao, Hanhan Dang, Xinyu Tao, Yue Lu, Dengfeng Lu, Yunsheng Zhang, Kun He, Jiancong Weng, Zhouqing Chen, Zhong Wang, Yanbing Yu   +15 more
wiley   +1 more source

Cyclin E1 overexpression triggers interferon signaling and is associated with antitumor immunity in breast cancer

Journal for ImmunoTherapy of Cancer
Background Cyclin E1 overexpression drives oncogenesis in several cancers through deregulation of DNA replication and induction of genomic instability, which may potentially trigger immune signaling via cytoplasmic DNA.
Bert van der Vegt, Carolien P Schroder, Rudolf S N Fehrmann, Shibo Yu, Chantal Stappenbelt, Mengting Chen, Mirte Dekker, Arkajyoti Bhattacharya, Tineke van der Sluis, Mieke C Zwager, Marcel A T M van Vugt   +10 more
doaj   +1 more source

Mitogen-activated protein kinase activation down-regulates a mechanism that inactivates cyclin B-cdc2 kinase in G2-arrested oocytes. [PDF]

, 1997
Ariane Abrieu, M. Dorée, A. Picard
openalex   +1 more source