Results 141 to 150 of about 222,589 (257)

RUNX1‐Mediated Hypoxic Signaling Impairs Myogenesis and Promotes Fibrosis in Myopathies

Advanced Science, EarlyView.
Myofiber overgrowth was associated with reduced blood flow and a potential hypoxic state in broiler breast muscle, accompanied by increased RUNX1 expression. Elevated RUNX1 impaired myogenic regeneration, promoted fibrosis, and disrupted the signaling niche required for efficient muscle repair, contributing to pathological degeneration in Wooden Breast
Liang Zhao, Taijiang Hou, Lin Zhang, Feng Gao, Tong Xing   +4 more
wiley   +1 more source

SP17 | AN INTEGRATED DIAGNOSTIC APPROACH COMBINING BONE MARROW BIOPSY AND FLOW CYTOMETRY IN FOUR CHALLENGING CASES OF SMALL B-CELL LYMPHOMA WITH LEUKEMIC PRESENTATION

Haematologica
Classification of small B-cell lymphomas with leukemic presentation can be challenging in the absence of nodal involvement. We highlight the value of an integrated diagnostic approach, combining bone marrow (BM) histopathology and flow cytometry (FC ...
F. Adotti, B. Mandelli, F. Arienzo, M.G. Pignataro, S. Trasarti, L. Bizzoni, M.S. De Propris, C. Giordano   +7 more
doaj  

SUMOylated DDX3 Promotes HBV Replication and Tumor Growth of Hepatocellular Carcinoma via TRIM28‐DDX3‐KLF4α Signaling Axis

Advanced Science, EarlyView.
TRIM28 binds to DDX3 protein to catalyze the SUMOylation of DDX3 (S‐DDX3), thus the S‐DDX3 involves in aberrant alternative splicing of KLF4 mRNA, and the splicing variant KLF4α‐mediated cell cycle and signal transduction, weakens tumor suppressor function of DDX3 protein, which promotes progression of HBV‐HCC.
Yanfang Yang, Ting Kong, Binghan Wang, Xiaoli Jin, Lan Huang, Nan Zhang, Siyu Tang, Samina Ejaz Syed, Shufang Liang   +8 more
wiley   +1 more source

MicroRNA‐941 Acts as a Novel Prognostic Predictor and Oncogenic Driver in Colorectal Cancer

Annals of Gastroenterological Surgery, EarlyView.
Upregulation of miR‐941 was a promising diagnostic and prognostic biomarker for CRC patients. Inhibition of miR‐941 significantly suppressed CRC cellular events and triggered ferroptosis. The oncogenic functions of miR‐941 were mediated through targeting TRPS1.
Hong Li, Yang Liu, Hua Chen, Jialin Li, Xinchun Li, Yanmin Chen   +5 more
wiley   +1 more source

PP1 promotes cyclin B destruction and the metaphase-anaphase transition by dephosphorylating CDC20. [PDF]

Mol Biol Cell, 2020
Bancroft J, Holder J, Geraghty Z, Alfonso-Pérez T, Murphy D, Barr FA, Gruneberg U.   +6 more
europepmc   +1 more source

Prenatal Presentation of RMRP‐Related Skeletal Dysplasia: Clinical and Genomic Expansion

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT The RNA subunit of the mitochondrial RNA processing endoribonuclease complex is encoded by RMRP. Biallelic variants in RMRP are known for anauxetic dysplasia 1 (AD), cartilage‐hair hypoplasia (CHH), and metaphyseal dysplasia without hypotrichosis.
Radhakrishnan Periyasamy, Pascal Joset, H. E. Veenstra‐Knol, Nicole Corsten‐Janssen, Tuula Rinne, Irene Valenzuela, Marta Codina‐Solà, Carlota Rodó, Marjolaine Willems, Constance Wells, Renaud Touraine, Maayke de Koning, Gijs Santen, Iris Hollink, André Travessa, Alessandro Mauro Spinelli, Paolo Peruzzo, Moneef Shoukier, Roland Axt‐Fliedner, Thomas Menter, Gwendolin Manegold‐Brauer, Isabel Filges   +21 more
wiley   +1 more source

Selective repression of the Drosophila cyclin B promoter by retinoblastoma and E2F proteins. [PDF]

Biochim Biophys Acta Gene Regul Mech, 2020
Mouawad R, Himadewi P, Kadiyala D, Arnosti DN.   +3 more
europepmc   +1 more source

Biomimetic Nanomedicine for Aging‐Impaired Bone Regeneration: From Microenvironmental Dysfunction to Precision Therapeutics

Advanced NanoBiomed Research, EarlyView.
Aging disrupts the cellular, immune, vascular, and neural processes required for bone regeneration. This review connects these pathological barriers with biomimetic nanomedicine design, highlighting strategies for cellular rejuvenation, immune modulation, vascular regeneration, and neuro–bone coupling.
Zeyu Wang, He Zhang, Simo Liu, Rui Wang, Yiran Wei, Kailu Zheng, Yanming Guo, Min Li, Dian Yuan, Yuxin Liu, Lifang Feng, Yongping Ma, Yan Liu   +12 more
wiley   +1 more source

Phosphorylation of NMDA receptors by cyclin B/CDK1 modulates calcium dynamics and mitosis. [PDF]

Commun Biol, 2020
Rosendo-Pineda MJ, Vicente JJ, Vivas O, Pacheco J, Loza-Huerta A, Sampieri A, Wordeman L, Moreno C, Vaca L.   +8 more
europepmc   +1 more source

SOX6 is expressed in various cell lineages in the developing mouse heart and contributes to proper valvuloseptal development

The Anatomical Record, EarlyView.
Abstract Cells derived from the endocardium, epicardium, cardiac neural crest, and second heart field play a critical role in the formation of the valvuloseptal structures of the heart. Previous studies have shown that the expression of the transcription factor SOX9 in these cell populations is essential in the regulation of this process.
Hannah G. Tarolli, Andrew B. Harvey, Inara Devji, Raymond N. Deepe, Jenna R. Drummond, Renélyn A. Wolters, Andy Wessels   +6 more
wiley   +1 more source