Results 181 to 190 of about 12,781,724 (361)

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

Advanced Science, EarlyView.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian, Yi‐Chun Ou, Zi‐Xian Zhang, Jie Cai, Si‐Qing Cai, Guo‐Gang Xing   +5 more
wiley   +1 more source

Cell cycle regulation of a Xenopus Wee1-like kinase [PDF]

, 1995
Using a polymerase chain reaction-based strategy, we have isolated a gene encoding a Wee1-like kinase from Xenopus eggs. The recombinant Xenopus Wee1 protein efficiently phosphorylates Cdc2 exclusively on Tyr- 15 in a cyclin-dependent manner.
Coleman, Thomas R., Dunphy, William G., Mueller, Paul R.   +2 more
core  

Restraining CDK1-cyclin B activation: PP2A on the cUSP(7). [PDF]

EMBO J, 2021
Chow-Castro M, Dixon SD, Saldivar JC.
europepmc   +1 more source

DualPG‐DTA: A Large Language Model‐Powered Graph Neural Network Framework for Enhanced Drug‐Target Affinity Prediction and Discovery of Novel CDK9 Inhibitors Exhibiting in Vivo Anti‐Leukemia Activity

Advanced Science, EarlyView.
This study introduces DualPG‐DTA, a framework integrating two pre‐trained models to generate molecular and protein representations. It constructs dual graphs processed by specialized neural networks with dynamic attention for feature fusion, achieving superior benchmark performance.
Yihao Chen, Jindi Huang, Cong Liu, Shipeng Zhang, Xinze Li, Zhang Zhang, Tie‐Gen Chen, Ling Wang   +7 more
wiley   +1 more source

Dynamic Mitotic Localization of the Centrosomal Kinases CDK1, Plk, AurK, and Nek2 in Dictyostelium amoebae

Cells
The centrosome of the amoebozoan model Dictyostelium discoideum provides the best-established model for an acentriolar centrosome outside the Opisthokonta.
Stefan Krüger, Nathalie Pfaff, Ralph Gräf, Irene Meyer   +3 more
doaj   +1 more source

Expression of the retinoblastoma protein in low-grade B-cell lymphoma: relationship to cyclin D1 [PDF]

, 1996
LR Zukerberg, W. F. Benedict, Andrew Arnold, Nicholas J. Dyson, E Harlow, NL Harris   +5 more
openalex   +1 more source

Cyclin D1 and Nuclear Factor Kappa B Expression in Oral Squamous Cell Carcinoma, Oral Submucous Fibrosis, and Oral Squamous Cell Carcinoma Associated with Oral Submucous Fibrosis - An Analytical Cross-Sectional Study

, 2021
Deepali Patekar, Sachin C. Sarode, Gargi S. Sarode, Pravin More   +3 more
openalex   +1 more source

Cdc13 (cyclin B) is degraded by autophagy under sulfur depletion in fission yeast. [PDF]

Autophagy Rep, 2022
Ohtsuka H, Hatta Y, Hayashi K, Shimasaki T, Otsubo Y, Ito Y, Tsutsui Y, Hattori N, Yamashita A, Murakami H, Aiba H.   +10 more
europepmc   +1 more source

Dual Targeting of Tau Kinases and Autophagy by Abemaciclib Independent of CDK4/6 Inhibition

Advanced Science, EarlyView.
Abemaciclib rescues cognitive function and attenuates tau pathology in Alzheimer's disease models, but not through its known cancer‐fighting mechanism. This study demonstrates that abemaciclib operates independently of CDK4/6 inhibition, instead directly targeting tau kinases CaMKII and GSK3β while simultaneously promoting autophagic clearance of ...
Jihui Han, June‐Hyun Jeong, Dongjoon Lee, Yujin Jung, Yujin Jin, Eun Sun Jung, Haeng Jun Kim, Woo Youn Kim, Chang‐Han Lee, Inhee Mook‐Jung   +9 more
wiley   +1 more source

Cleft Palate Induced by Mycophenolate Mofetil Is Associated with miR-4680-3p and let-7c-5p in Human Palate Cells

Non-Coding RNA
Background/Objectives: Cleft palate is a birth defect associated with environmental and genetic factors. Disturbance of microRNAs (miRNAs) and exposure to medicinal agents during pregnancy can cause cleft palate.
Hiroki Yoshioka, Hanane Horita, Yosuke Tsukiboshi, Hisaka Kurita, Aya Ogata, Kenichi Ogata   +5 more
doaj   +1 more source